Search Results - "Gayler, Kevin M"

Synthetic studies towards the penicisulfuranols: Synthesis of an advanced spirocyclic diketopiperazine intermediate by Gayler, Kevin M., Lambert, Kyle M., Wood, John L.

“…The 2,5-diketopiperazine (DKP) moiety is a core feature of many natural products and medicinally relevant scaffolds. As part of our efforts directed towards a…”
Get full text

Endosomal trafficking inhibitor EGA can control TLR7-mediated IFNα expression by human plasmacytoid dendritic cells by Wiest, Matthew J, Baert, Laurie, Gu, Chao, Gayler, Kevin M, Ham, Hyoungjun, Gorvel, Laurent, Keddis, Mira T, Griffing, Leroy W, Joo, HyeMee, Gorvel, Jean-Pierre, Billadeau, Daniel D, Kane, Robert R, Oh, SangKon

“…Plasmacytoid dendritic cells (pDC) are the major producer of type 1 IFN in response to TLR7 agonists. Aberrant TLR7 activation and type 1 IFN expression by…”
Get full text

Gemfibrozil derivatives as activators of soluble guanylyl cyclase – A structure-activity study by Gayler, Kevin M., Quintana, Jeremy M., Mattke, Jordan, Plunk, Michael A., Kostyo, Jessica H., Karunananthan, Johann W., Nguyen, Harold, Shuda, Mina, Ferreira, Liam D., Baker, Hannah, Stinchcomb, Alexandra L., Sharina, Iraida, Kane, Robert R., Martin, Emil

“…Previous studies demonstrated that anti-hyperlipidemic drug gemfibrozil acts as NO- and heme-independent activator of NO receptor soluble guanylyl cyclase. A…”
Get full text

Staurosporine Analogs Via C–H Borylation by Gayler, Kevin M, Kong, Ke, Reisenauer, Keighley, Taube, Joseph H, Wood, John L

“…Staurosporine is among the most potent naturally occurring kinase inhibitors isolated to date and has served as a lead compound for numerous drug development…”
Get full text