Systemic redox imbalance along with increased serum sialic acid is prevalent in patients with active vitiligo: A study from a tertiary care teaching hospital of eastern India

Systemic redox imbalance along with increased serum sialic acid is prevalent in patients with active vitiligo: A study from a tertiary care teaching hospital of eastern India

Background: Vitiligo is one of the common depigmenting disorders causing disfigurement and affecting the quality of life. Redox imbalance is known to play a contributory role in melanocyte destruction. Serum sialic acid (SA) is an important marker of the acute-phase response and is associated with o...

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Published in:Indian journal of dermatology Vol. 64; no. 2; pp. 97 - 100
Main Authors: Banerjee, Nilotpal, Gayen, Sanchaita, Modak, Dolanchampa, Sarkar, Somenath, Saha, Bibhuti, Mukhopadhyay, Sumi
Format: Journal Article
Language:English
Published: India Wolters Kluwer India Pvt. Ltd 01-03-2019
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects:
Active vitiligo
Age
Analysis
Antioxidants
Biological markers
Disease
Free radicals
Lipid peroxidation
malondialdehyde
Medical research
Organic acids
Original
Oxidative stress
Pathogenesis
Patients
redox imbalance
serum sialic acid
Sialic acids
Skin
Software
Statistical analysis
superoxide dismutase
Superoxides
Teachers
Vitiligo
La Jolla California
West Bengal
United States > US
India
Active vitiligo
serum sialic acid
malondialdehyde
redox imbalance
superoxide dismutase
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Summary:Background: Vitiligo is one of the common depigmenting disorders causing disfigurement and affecting the quality of life. Redox imbalance is known to play a contributory role in melanocyte destruction. Serum sialic acid (SA) is an important marker of the acute-phase response and is associated with oxidative protein damage. Aim: The aim of this study was to analyze the status of oxidative stress markers and serum SA in vitiligo patients and to correlate the same with disease activity. Materials and Methods: The different oxidative stress parameters namely superoxide dismutase (SOD), malondialdehyde (MDA), and serum SA were measured spectrophotometrically using standard biochemical methodologies in all the study subjects. Results: Serum SOD and MDA values were higher in patients with active vitiligo (n = 23) as compared to stable vitiligo (n = 20) and healthy controls (n = 20). The MDA/SOD ratio was higher in patients with active vitiligo (P<0.0001). Serum SA was increased in active vitiligo as compared to stable vitiligo and healthy controls (P<0.0001). Conclusion: This study indicates that patients with active vitiligo demonstrate enhanced MDA/SOD ratio and increased serum SA. The studied parameters can serve as an important tool to monitor disease activity in vitiligo.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:0019-5154
1998-3611
DOI:10.4103/ijd.IJD_448_17