Early centralized isolation strategy for all confirmed cases of COVID-19 remains a core intervention to disrupt the pandemic spreading significantly

In response to the spread of the coronavirus disease 2019 (COVID-19), plenty of control measures were proposed. To assess the impact of current control measures on the number of new case indices 14 countries with the highest confirmed cases, highest mortality rate, and having a close relationship wi...

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Published in:	PloS one Vol. 16; no. 7; p. e0254012
Main Authors:	Nam, Nguyen Hai, Tien, Phan Thi My, Truong, Le Van, El-Ramly, Toka Aziz, Anh, Pham Gia, Hien, Nguyen Thi, Mahmoud, El Marabea, Eltaras, Mennatullah Mohamed, Khader, Sarah Abd Elaziz, Desokey, Mohammed Salah, Gayed, Ramy Magdy, Alhady, Shamael Thabit Mohammed, Le, Bao-Tran Do, Nguyen, Do Phuc Nhu, Tiwari, Ranjit, Eldoadoa, Mohammed, Howard, Britney, Trung, Tran Thanh, Huy, Nguyen Tien
Format:	Journal Article
Language:	English
Published:	San Francisco Public Library of Science 15-07-2021 Public Library of Science (PLoS)
Subjects:	Control Coronaviruses COVID-19 Disease transmission Earth Sciences Epidemics Evaluation Hospitals Impact analysis Infections International organizations Medicine Medicine and Health Sciences Mental health Outbreaks Pandemics People and Places Pharmacy Prevention Public health Public health administration Respiratory diseases Schools Severe acute respiratory syndrome coronavirus 2 Social Sciences Software Viral diseases Japan United Kingdom > UK United States > US Egypt California Spain Canada Los Angeles California Cairo Egypt Sweden Vietnam China Italy France Germany
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Summary:	In response to the spread of the coronavirus disease 2019 (COVID-19), plenty of control measures were proposed. To assess the impact of current control measures on the number of new case indices 14 countries with the highest confirmed cases, highest mortality rate, and having a close relationship with the outbreak's origin; were selected and analyzed. In the study, we analyzed the impact of five control measures, including centralized isolation of all confirmed cases, closure of schools, closure of public areas, closure of cities, and closure of borders of the 14 targeted countries according to their timing; by comparing its absolute effect average, its absolute effect cumulative, and its relative effect average. Our analysis determined that early centralized isolation of all confirmed cases was represented as a core intervention in significantly disrupting the pandemic's spread. This strategy helped in successfully controlling the early stage of the outbreak when the total number of cases were under 100, without the requirement of the closure of cities and public areas, which would impose a negative impact on the society and its economy. However, when the number of cases increased with the apparition of new clusters, coordination between centralized isolation and non-pharmaceutical interventions facilitated control of the crisis efficiently. Early centralized isolation of all confirmed cases should be implemented at the time of the first detected infectious case.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0254012