Search Results - "Gay, Bryant"

Structure Property Relationships of Carboxylic Acid Isosteres by Lassalas, Pierrik, Gay, Bryant, Lasfargeas, Caroline, James, Michael J, Tran, Van, Vijayendran, Krishna G, Brunden, Kurt R, Kozlowski, Marisa C, Thomas, Craig J, Smith, Amos B, Huryn, Donna M, Ballatore, Carlo

“…The replacement of a carboxylic acid with a surrogate structure, or (bio)-isostere, is a classical strategy in medicinal chemistry. The general underlying…”
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Personalized medicine: Vinpocetine to reverse effects of GABRB3 mutation by Billakota, Santoshi, Andresen, J. Michael, Gay, Bryant C., Stewart, Gregory R., Fedorov, Nikolai B., Gerlach, Aaron C., Devinsky, Orrin

“…Objective To screen a library of potential therapeutic compounds for a woman with Lennox‐Gastaut syndrome due to a Y302C GABRB3 (c.905A>G) mutation. Methods We…”
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Brain-Penetrant, Orally Bioavailable Microtubule-Stabilizing Small Molecules Are Potential Candidate Therapeutics for Alzheimer’s Disease and Related Tauopathies by Lou, Kevin, Yao, Yuemang, Hoye, Adam T, James, Michael J, Cornec, Anne-Sophie, Hyde, Edward, Gay, Bryant, Lee, Virginia M.-Y, Trojanowski, John Q, Smith, Amos B, Brunden, Kurt R, Ballatore, Carlo

“…Microtubule (MT) stabilizing drugs hold promise as potential treatments for Alzheimer’s disease (AD) and related tauopathies. However, thus far epothilone D…”
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A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy by Atkin, Talia A., Maher, Chani M., Gerlach, Aaron C., Gay, Bryant C., Antonio, Brett M., Santos, Sonia C., Padilla, Karen M., Rader, JulieAnn, Krafte, Douglas S., Fox, Matthew A., Stewart, Gregory R., Petrovski, Slavé, Devinsky, Orrin, Might, Matthew, Petrou, Steven, Goldstein, David B.

“…Summary Objective Many previous studies of drug repurposing have relied on literature review followed by evaluation of a limited number of candidate compounds…”
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Synthesis and evaluation of the anti-proliferative and NF-κB activities of a library of simplified tylophorine analogs by Niphakis, Micah J., Gay, Bryant C., Hong, Kwon Ho, Bleeker, Nicholas P., Georg, Gunda I.

“…Tylophorine and many related phenanthropiperidine alkaloids are extraordinarily potent anti-proliferative agents. Despite their impressive anti-cancer…”
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A comprehensive approach to identifying repurposed drugs to treat SCN 8A epilepsy by Atkin, Talia A., Maher, Chani M., Gerlach, Aaron C., Gay, Bryant C., Antonio, Brett M., Santos, Sonia C., Padilla, Karen M., Rader, JulieAnn, Krafte, Douglas S., Fox, Matthew A., Stewart, Gregory R., Petrovski, Slavé, Devinsky, Orrin, Might, Matthew, Petrou, Steven, Goldstein, David B.

“…Summary Objective Many previous studies of drug repurposing have relied on literature review followed by evaluation of a limited number of candidate compounds…”
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Synthesis and evaluation of the anti-proliferative and NF-[kappa]B activities of a library of simplified tylophorine analogs by Niphakis, Micah J, Gay, Bryant C, Hong, Kwon Ho, Bleeker, Nicholas P, Georg, Gunda I

“…Tylophorine and many related phenanthropiperidine alkaloids are extraordinarily potent anti-proliferative agents. Despite their impressive anti-cancer…”
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Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group by Ballatore, Carlo, Gay, Bryant, Huang, Longchuan, Robinson, Katie Herbst, James, Michael J., Trojanowski, John Q., Lee, Virginia M.-Y., Brunden, Kurt R., Smith, Amos B.

“…Cycloalkylpolyones hold promise in drug design as carboxylic acid bio-isosteres. To investigate cyclopentane-1,2-diones as potential surrogates of the…”
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Evaluation of Density Functionals, SCC-DFTB, Neglect of Diatomic Differential Overlap (NDDO) Models and Molecular Mechanics Methods for Prolyl-Leucyl-Glycinamide (PLG) and Structural Derivatives by Wood, Richard L, Young-Dixon, Brendan J, Roy, Abhrajeet, Gay, Bryant C, Johnson, Rodney L, Amin, Elizabeth A

“…Prolyl-leucyl-glycinamide (PLG) is a unique endogenous peptide that modulates dopamine receptor subtypes of the D(2) receptor family within the CNS. We seek to…”
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Cyclic enaminones: Synthons for piperidine containing natural products and natural product analogs by Gay, Bryant Charles

“…Cyclic enaminones are important synthetic intermediates for the preparation of piperidine containing natural products and target molecules such as drugs, which…”
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Cyclic enaminones: Synthons for piperidine containing natural products and natural product analogs by Gay, Bryant Charles

“…Cyclic enaminones are important synthetic intermediates for the preparation of piperidine containing natural products and target molecules such as drugs, which…”
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The home office by Bryant, Gay

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Thriving beyond the corporation by Bryant, Gay

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Evaluation of density functionals, SCC-DFTB, neglect of diatomic differential overlap (NDDO) models and molecular mechanics methods for prolyl-leucyl-glycinamide (PLG) and structural analogs by Wood, Richard L., Young-Dixon, Brendan J., Roy, Abhrajeet, Gay, Bryant C., Johnson, Rodney L., Amin, Elizabeth A.

“…Prolyl-leucyl-glycinamide (PLG) is a unique endogenous peptide that modulates dopamine receptor subtypes of the D 2 receptor family within the CNS. We seek to…”
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Allied health applications of a computerized clinical log database system by Boyce, K E, Winn, J S, Anderson, S L, Bryant, B G

“…Preliminary research in the development and use of computerized clinical log records began in 1987 in an allied health college at a midwestern academic health…”
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