Search Results - "Gawri, R"

A novel mouse model of polytrauma with spinal cord injury–associated heterotopic ossification by Aita, R, Unnithan, G, Klaylat, T, Petruccelli, JA, St-Jean, G, Radhakrishna, M, Gawri, R, Gao, C

“…Heterotopic ossification (HO) refers to abnormal bone formation in soft tissues, which is a common complication of traumatic spinal cord injury (SCI). Current…”
Get full text

Dynamic loading, matrix maintenance and cell injection therapy of human intervertebral discs cultured in a bioreactor by Rosenzweig, D H, Gawri, R, Moir, J, Beckman, L, Eglin, D, Steffen, T, Roughley, P J, Ouellet, J A, Haglund, L

“…Low back pain originating from intervertebral disc (IVD) degeneration affects the quality of life for millions of people, and it is a major contributor to…”
Get full text

Mechanism of parathyroid hormone-mediated suppression of calcification markers in human intervertebral disc cells by Madiraju, P, Gawri, R, Wang, H, Antoniou, J, Mwale, F

“…In degenerative intervertebral discs (IVD), type X collagen (COL X) expression (associated with hypertrophic differentiation) and calcification has been…”
Get full text

Best paper NASS 2013: link-N can stimulate proteoglycan synthesis in the degenerated human intervertebral discs by Gawri, Rahul, Antoniou, John, Ouellet, Jean, Awwad, Waleed, Steffen, Thomas, Roughley, Peter, Haglund, Lisbet, Mwale, Fackson

“…Intervertebral disc (IVD) degeneration is the most common cause of back pain. Presently there is no medical treatment, leaving surgery as the only offered…”
Get full text

Development of a whole disc organ culture system to study human intervertebral disc by Parolin, M, Gawri, R, Mwale, F, Steffen, T, Roughley, P, Antoniou, J, Jarzem, P, Haglund, L, Ouellet, J

“…Basic science Objective:  Low back pain is one of the most common health problems1 and is strongly associated with intervertebral disc degeneration, (IVD)…”
Get full text

Effect of synthetic link N peptide on the expression of type I and type II collagens in human intervertebral disc cells by Petit, Alain, Yao, Guoying, Rowas, Sora Al, Gawri, Rahul, Epure, Laura, Antoniou, John, Mwale, Fackson

“…Intervertebral disc (IVD) degeneration is associated with proteolytic degradation of proteoglycan aggregates present within the extracellular matrix of the…”
Get more information

The Ability of Physiological Load to Restore Disc Function by Ouellet, J. A., Steffen, T., Moir, J., Gawri, R., Roughley, P., Haglund, L. A.

“…Introduction The nucleus pulposus (NP) of a healthy intervertebral disc (IVD) is rich in collagen type II fibers that are arranged in a random fashion to…”
Get full text

Effect of Parathyroid Hormone on MAPK Signaling and Calcification Markers in Human Intervertebral Disk Cells by Madiraju, P., Gawri, R., Antoniou, J., Mwale, F.

“…Introduction Back pain is strongly associated with degeneration of the intervertebral disk (IVD), which is associated with ongoing mineral deposition.1 The…”
Get full text

Link-N is Cleaved by Human Annulus Fibrosus Cells Generating a Fragment with Retained Biological Activity by Gawri, R., Ouellet, J., Önnerfjord, P., Alkhatib, B., Steffen, T., Heinegård, D., Roughley, P., Antoniou, J., Mwale, F., Haglund, L.

“…Introduction Back pain affects a large portion of the population across all ages, and intervertebral disc (IVD) degeneration is its most common cause…”
Get full text

Acute Mechanical Injury to the Human Intervertebral Disc Initiates Events Implicated in Disc Degeneration by Alkhatib, B. Ghalib, Rosenzweig, D., Krock, E., Gawri, R., Beckman, L., Steffen, T., Weber, M., Ouellet, J., Haglund, L.

“…Introduction Low back pain is a prevalent chronic disorder among individuals worldwide. Intervertebral disc degeneration is a major cause of low back pain in…”
Get full text

High Mechanical Strain of Intervertebral Disc Cells Promotes Secretion of Inflammatory Factors Associated with Disc Degeneration and Pain by Rosenzweig, D. H., Gawri, R., Krock, E., Ouellet, J. A., Stone, L. S., Quinn, T. M., Haglund, L.

“…Introduction Low back pain is a debilitating disorder affecting a multitude of people and is currently ranked sixth among costliest treatable chronic…”
Get full text

New Insight into Human Disc Degeneration by Gene Expression Profiling by Grad, S., Gawri, R., Haglund, L., Ouellet, J., Mwale, F., Creemers, L. B., Rutges, J. P. H. J., Gallagher, W. M., O'Gaora, P., Pandit, A., Alini, M.

“…Introduction Intervertebral disc (IVD) degeneration is characterized by the breakdown of extracellular matrix molecules and is often associated with…”
Get full text

Link-N Peptide: A Stepping Stone towards Biological Repair of Intervertebral Disk Degeneration by Gawri, R., Antoniou, J., Ouellet, J., Roughley, P., Steffen, T., Haglund, L. A., Mwale, F.

“…Introduction Back pain is a fairly common problem which affects a large portion of the population across all ages and has an impact on quality of life…”
Get full text

Optimization of Bioreactor Design for Normal Loading of Human Intervertebral Disks by Gawri, R., Althukair, R., Moir, J., Roughley, P., Ouellet, J., Steffen, T., Haglund, L. A.

“…Introduction Intervertebral disk (IVD) degeneration is a common cause of back pain, which has a negative impact on the quality of life of the patient and is…”
Get full text

The Effect of Intervertech 1 on Proteoglycan and Collagen Expression in Human Intervertebral Disk Cells by Mwale, F., Wang, H. T., Madiraju, P., Gawri, R., Almaawi, A., Haglund, L., Antoniou, J.

“…Introduction Back pain is one the most frequent complaints and has an impact on the quality of life. Intervertebral disk (IVD) degeneration is the single most…”
Get full text

Effect of In-Utero Exposure to High Dose Diethylstilbestrol on Intervertebral Disk in Adult Male and Female Progeny by Al Rowas, S., Gawri, R., Haddad, R., Almaawi, A., Chalifour, L. E., Antoniou, J., Mwale, F.

“…Introduction In utero exposure to Diethylstilbestrol (DES) has been shown to adversely affect a number of estrogen sensitive tissues, including bone. Effects…”
Get full text

Chondroadherin Fragmentation as a Biochemical Marker for Early Stage Disk Degeneration by Alkhatib, B., Gawri, R., önnerfjord, P., Ouellet, J., Roughley, P., Steffen, T., Haglund, L. A.

“…Introduction Intervertebral disk (IVD) degeneration has been strongly associated with and named a major cause of back pain. At present, little is known about…”
Get full text

Effect of Nitrogen-Rich Cell Culture Surfaces on TGF BETA and MAPK Signaling in Intervertebral Disk Cells by Madiraju, P., St-Georges-Robillard, A., Gawri, R., Antoniou, J., Wertheimer, M. R., Mwale, F.

“…Introduction Low back pain, often due to intervertebral disk (IVD) degeneration, is an age-associated disorder that afflicts more than half of the population,…”
Get full text

Effect of Intervertech-1 Levels on Proteoglycan Synthesis by Intervertebral Disk Cells by Gawri, R., Haglund, L. A., Ouellet, J., Antoniou, J., Mwale, F.

“…Introduction Back pain is a fairly common problem, which affects a large portion of the population across all ages and has an impact on quality of life. It has…”
Get full text

Inquisition of the Human Intervertebral Disk Histopathology with the Use of Two Histological Staining Methods by Ferland, C. E., Tabatabaei Shafiei, Z. S., Gawri, R., Haglund, L., Ouellet, J. A., Stone, L. S.

“…Introduction Chronic low back pain (LBP) affects over 10% of the adult population resulting in profound decreases in the quality of life. The intervertebral…”
Get full text