Neuroprotective properties of afobazol in vitro

Neuroprotective properties of afobazol in vitro

The effects of a novel selective anxiolytic afobazol on survival of HT-22 neurons were studied in the model of oxidative stress and glutamate toxicity. In both models, the neuroprotective effect of afobazol was established.

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 140; no. 2; pp. 194 - 196
Main Authors: Zenina, T A, Gavrish, I V, Melkumyan, D S, Seredenina, T S, Seredenin, S B
Format: Journal Article
Language:English
Published: United States Springer Nature B.V 01-08-2005
Subjects:
Animals
Benzimidazoles - pharmacology
Cell Line
Cell Survival
Glutamic Acid - chemistry
Glutamic Acid - metabolism
Hydrogen Peroxide - metabolism
In Vitro Techniques
Mice
Morpholines - pharmacology
Neurons - metabolism
Neuroprotective Agents - pharmacology
Oxidative Stress
Tetrazolium Salts - pharmacology
Thiazoles - pharmacology
Time Factors
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Description
Summary:The effects of a novel selective anxiolytic afobazol on survival of HT-22 neurons were studied in the model of oxidative stress and glutamate toxicity. In both models, the neuroprotective effect of afobazol was established.
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content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-005-0443-7