Search Results - "Gavrilin, Mikhail A."

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation by Ratner, Dmitry, Orning, M Pontus A, Proulx, Megan K, Wang, Donghai, Gavrilin, Mikhail A, Wewers, Mark D, Alnemri, Emad S, Johnson, Peter F, Lee, Bettina, Mecsas, Joan, Kayagaki, Nobuhiko, Goguen, Jon D, Lien, Egil

“…Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects…”
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Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function by Ghonime, Mohammed G, Shamaa, Obada R, Das, Srabani, Eldomany, Ramadan A, Fernandes-Alnemri, Teresa, Alnemri, Emad S, Gavrilin, Mikhail A, Wewers, Mark D

“…Caspase-1 activation is a central event in innate immune responses to many pathogenic infections and tissue damage. The NLRP3 inflammasome, a multiprotein…”
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Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1 by Shamaa, Obada R, Mitra, Srabani, Gavrilin, Mikhail A, Wewers, Mark D

“…Mononuclear phagocytes utilize caspase-1 activation as a means to respond to danger signals. Although caspase-1 was discovered using highly concentrated cell…”
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Checks and Balances between Autophagy and Inflammasomes during Infection by Seveau, Stephanie, Turner, Joanne, Gavrilin, Mikhail A., Torrelles, Jordi B., Hall-Stoodley, Luanne, Yount, Jacob S., Amer, Amal O.

“…Autophagy and inflammasome complex assembly are physiological processes that control homeostasis, inflammation, and immunity. Autophagy is a ubiquitous pathway…”
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Adenovirus VA RNAI Blocks ASC Oligomerization and Inhibits NLRP3 Inflammasome Activation by Darweesh, Mahmoud, Kamel, Wael, Gavrilin, Mikhail A, Akusjärvi, Göran, Svensson, Catharina

“…Virus infected immune cells can rapidly respond to the invader by activating the inflammasome and as a consequence release proinflammatory cytokines and…”
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Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization by Akhter, Anwari, Caution, Kyle, Abu Khweek, Arwa, Tazi, Mia, Abdulrahman, Basant A., Abdelaziz, Dalia H.A., Voss, Oliver H., Doseff, Andrea I., Hassan, Hoda, Azad, Abul K., Schlesinger, Larry S., Wewers, Mark D., Gavrilin, Mikhail A., Amer, Amal O.

“…Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once…”
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Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation by Caution, Kyle, Young, Nicholas, Robledo-Avila, Frank, Krause, Kathrin, Abu Khweek, Arwa, Hamilton, Kaitlin, Badr, Asmaa, Vaidya, Anup, Daily, Kylene, Gosu, Hawin, Anne, Midhun N K, Eltobgy, Mostafa, Dakhlallah, Duaa, Argwal, Sudha, Estfanous, Shady, Zhang, Xiaoli, Partida-Sanchez, Santiago, Gavrilin, Mikhail A, Jarjour, Wael N, Amer, Amal O

“…Gout is characterized by attacks of arthritis with hyperuricemia and monosodium urate (MSU) crystal-induced inflammation within joints. Innate immune responses…”
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Human Placental Trophoblasts Infected by Listeria monocytogenes Undergo a Pro-Inflammatory Switch Associated With Poor Pregnancy Outcomes by Johnson, Lauren J, Azari, Siavash, Webb, Amy, Zhang, Xiaoli, Gavrilin, Mikhail A, Marshall, Joanna M, Rood, Kara, Seveau, Stephanie

“…The placenta controls the growth of the fetus and ensures its immune protection. Key to these functions, the syncytiotrophoblast (SYN) is a syncytium formed by…”
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Elevated Expression of MiR-17 in Microglia of Alzheimer's Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation by Estfanous, Shady, Daily, Kylene P, Eltobgy, Mostafa, Deems, Nicholas P, Anne, Midhun N K, Krause, Kathrin, Badr, Asmaa, Hamilton, Kaitlin, Carafice, Cierra, Hegazi, Ahmad, Abu Khweek, Arwa, Kelani, Hesham, Nimjee, Shahid, Awad, Hamdy, Zhang, Xiaoli, Cormet-Boyaka, Estelle, Haffez, Hesham, Soror, Sameh, Mikhail, Adel, Nuovo, Gerard, Barrientos, Ruth M, Gavrilin, Mikhail A, Amer, Amal O

“…Autophagy is a proposed route of amyloid-β (Aβ) clearance by microglia that is halted in Alzheimer's Disease (AD), though mechanisms underlying this…”
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Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis by Abdulrahman, Basant A., Khweek, Arwa Abu, Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Abdelaziz, Dalia H.A., Newland, Christie, Rosales-Reyes, Roberto, Kopp, Benjamin, McCoy, Karen, Montione, Richard, Schlesinger, Larry S., Gavrilin, Mikhail A., Wewers, Mark D., Valvano, Miguel A., Amer, Amal O.

“…Cystic fibrosis (CF) is the most common inherited lethal disease of Caucasians which results in multi organ dysfunction. However, 85% of the deaths are due to…”
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Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo by Estfanous, Shady, Krause, Kathrin, Anne, Midhun N. K., Eltobgy, Mostafa, Caution, Kyle, Abu Khweek, Arwa, Hamilton, Kaitlin, Badr, Asmaa, Daily, Kylene, Carafice, Cierra, Baetzhold, Daniel, Zhang, Xiaoli, Li, Tianliang, Wen, Haitao, Gavrilin, Mikhail A., Haffez, Hesham, Soror, Sameh, Amer, Amal O.

“…Burkholderia cenocepacia ( B. cenocepacia ) is an opportunistic bacterium; causing severe life threatening systemic infections in immunocompromised individuals…”
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Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation by Hoyt, Laura R, Ather, Jennifer L, Randall, Matthew J, DePuccio, Daniel P, Landry, Christopher C, Wewers, Mark D, Gavrilin, Mikhail A, Poynter, Matthew E

“…Immunosuppression is a major complication of alcoholism that contributes to increased rates of opportunistic infections and sepsis in alcoholics. The NLRP3…”
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Docosahexaenoic Acid Suppresses Silica-Induced Inflammasome Activation and IL-1 Cytokine Release by Interfering With Priming Signal by Wierenga, Kathryn A, Wee, Josephine, Gilley, Kristen N, Rajasinghe, Lichchavi D, Bates, Melissa A, Gavrilin, Mikhail A, Holian, Andrij, Pestka, James J

“…Occupational exposure to respirable crystalline silica (cSiO ) has been etiologically linked to human autoimmunity. Intranasal instillation with cSiO triggers…”
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Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia by Gavrilin, Mikhail A, Abdelaziz, Dalia H A, Mostafa, Mahmoud, Abdulrahman, Basant A, Grandhi, Jaykumar, Akhter, Anwari, Abu Khweek, Arwa, Aubert, Daniel F, Valvano, Miguel A, Wewers, Mark D, Amer, Amal O

“…Burkholderia cenocepacia is an opportunistic pathogen that causes chronic infection and induces progressive respiratory inflammation in cystic fibrosis…”
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Angiotensin Receptor Expression and Vascular Endothelial Dysfunction in Obstructive Sleep Apnea by Khayat, Rami N, Varadharaj, Saradhadevi, Porter, Kyle, Sow, Angela, Jarjoura, David, Gavrilin, Mikhail A, Zweier, Jay L

“…Abstract BACKGROUND Obstructive sleep apnea (OSA) is associated with vascular endothelial dysfunction (VED) in otherwise healthy patients. The role of…”
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Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection by Akhter, Anwari, Gavrilin, Mikhail A, Frantz, Laura, Washington, Songcerae, Ditty, Cameron, Limoli, Dominique, Day, Colby, Sarkar, Anasuya, Newland, Christie, Butchar, Jonathan, Marsh, Clay B, Wewers, Mark D, Tridandapani, Susheela, Kanneganti, Thirumala-Devi, Amer, Amal O

“…Legionella pneumophila (L. pneumophila), the causative agent of a severe form of pneumonia called Legionnaires' disease, replicates in human monocytes and…”
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Omega-3 Docosahexaenoic Acid (DHA) Impedes Silica-Induced Macrophage Corpse Accumulation by Attenuating Cell Death and Potentiating Efferocytosis by Rajasinghe, Lichchavi D, Chauhan, Preeti S, Wierenga, Kathryn A, Evered, Augustus O, Harris, Shamya N, Bates, Melissa A, Gavrilin, Mikhail A, Pestka, James J

“…Airway exposure of lupus-prone NZBWF1 mice to crystalline silica (cSiO ), a known trigger of human autoimmune disease, elicits sterile inflammation and…”
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CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages by Badr, Asmaa, Eltobgy, Mostafa, Krause, Kathrin, Hamilton, Kaitlin, Estfanous, Shady, Daily, Kylene P, Abu Khweek, Arwa, Hegazi, Ahmad, Anne, Midhun N K, Carafice, Cierra, Robledo-Avila, Frank, Saqr, Youssra, Zhang, Xiaoli, Bonfield, Tracey L, Gavrilin, Mikhail A, Partida-Sanchez, Santiago, Seveau, Stephanie, Cormet-Boyaka, Estelle, Amer, Amal O

“…Cystic fibrosis (CF) human and mouse macrophages are defective in their ability to clear bacteria such as . The autophagy process in CF (F508del) macrophages…”
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Author Correction: Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo by Estfanous, Shady, Krause, Kathrin, Anne, Midhun N. K., Eltobgy, Mostafa, Caution, Kyle, Khweek, Arwa Abu, Hamilton, Kaitlin, Badr, Asmaa, Daily, Kylene, Carafice, Cierra, Baetzhold, Daniel, Zhang, Xiaoli, Li, Tianliang, Wen, Haitao, Gavrilin, Mikhail A., Haffez, Hesham, Soror, Sameh, Amer, Amal O.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Gene Expression Profiling Identifies MMP-12 and ADAMDEC1 as Potential Pathogenic Mediators of Pulmonary Sarcoidosis by Crouser, Elliott D, Culver, Daniel A, Knox, Kenneth S, Julian, Mark W, Shao, Guohong, Abraham, Susamma, Liyanarachchi, Sandya, Macre, Jennifer E, Wewers, Mark D, Gavrilin, Mikhail A, Ross, Patrick, Abbas, Abbas, Eng, Charis

“…Little is known about the genetic regulation of granulomatous inflammation in sarcoidosis. To determine if tissue gene array analysis would identify novel…”
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