Search Results - "Gavioli, Elaine C"

NOP agonists prevent the antidepressant-like effects of nortriptyline and fluoxetine but not R-ketamine by Holanda, Victor A. D., Santos, Wilton B., Asth, Laila, Guerrini, Remo, Calo’, Girolamo, Ruzza, Chiara, Gavioli, Elaine C.

“…Rationale Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand of a Gi protein-coupled receptor named NOP. Both N/OFQ and NOP receptor are widely expressed…”
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NOP agonist action of cebranopadol counteracts its liability to promote physical dependence by Ruzza, Chiara, Holanda, Victor A., Gavioli, Elaine C., Trapella, Claudio, Calo, Girolamo

“…•Cebranopadol is an innovative analgesic acting as mixed NOP/opioid receptor agonist.•Cebranopadol evoked a stronger withdrawal syndrome in NOP(-/-) than…”
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Effects of Stress Exposure to Pain Perception in Pre-Clinical Studies: Focus on the Nociceptin/Orphanin FQ-NOP Receptor System by Pola, Pietro, Frezza, Alessia, Gavioli, Elaine C, Calò, Girolamo, Ruzza, Chiara

“…Exposure to physical and psychological stress modulates pain transmission in a dual manner. Stress-induced analgesia (SIA) refers to the reduction in pain…”
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Effects of chronic mild stress on the oxidative parameters in the rat brain by Lucca, Giancarlo, Comim, Clarissa M., Valvassori, Samira S., Réus, Gislaine Z., Vuolo, Francieli, Petronilho, Fabrícia, Dal-Pizzol, Felipe, Gavioli, Elaine C., Quevedo, João

“…Major depression is characterized for symptoms at the psychological, behavioral and physiological levels. The chronic mild stress model has been used as an…”
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Essential Oils and Their Constituents: An Alternative Source for Novel Antidepressants by de Sousa, Damião P, Silva, Rayanne H N, Silva, Epifanio F da, Gavioli, Elaine C

“…Depression is a disease that has affected a high proportion of the world's population and people of different ages, incapacitating them from good performance…”
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Peptide welding technology – A simple strategy for generating innovative ligands for G protein coupled receptors by Calo’, Girolamo, Rizzi, Anna, Ruzza, Chiara, Ferrari, Federica, Pacifico, Salvatore, Gavioli, Elaine C., Salvadori, Severo, Guerrini, Remo

“…•The PWT strategy allows the facile synthesis of tetrabranched peptides.•In vitro PWT derivatives maintain the pharmacological features of parent peptides.•In…”
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Blockade of nociceptin/orphanin FQ signaling facilitates an active copying strategy due to acute and repeated stressful stimuli in mice by Holanda, Victor A.D., Oliveira, Matheus C., Da Silva Junior, Edilson D., Calo', Girolamo, Ruzza, Chiara, Gavioli, Elaine C.

“…The role of stress in the etiology of depression has been largely reported. In this line, exogenous glucocorticoids are employed to mimic the influence of…”
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Neuropeptide S Receptor as an Innovative Therapeutic Target for Parkinson Disease by Holanda, Victor A. D., Didonet, Julia J., Costa, Manara B. B., do Nascimento Rangel, Adriano H., da Silva, Edilson D., Gavioli, Elaine C.

“…Parkinson disease (PD) is a neurodegenerative disease mainly characterized by the loss of nigral dopaminergic neurons in the substantia nigra pars compacta…”
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Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vivo studies by Rizzi, Anna, Gavioli, Elaine C, Marzola, Giuliano, Spagnolo, Barbara, Zucchini, Silvia, Ciccocioppo, Roberto, Trapella, Claudio, Regoli, Domenico, Calò, Girolamo

“…The excellent pharmacological profile displayed by the selective nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor antagonist SB-612111…”
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Anxiogenic-like profile of Wistar adult rats based on the pilocarpine model: an animal model for trait anxiety? by Duarte, Filipe S., Duzzioni, Marcelo, Hoeller, Alexandre A., Silva, Nayana M., Ern, Andy L., Piermartiri, Tetsade C., Tasca, Carla I., Gavioli, Elaine C., Lemos, Tadeu, Carobrez, Antonio P., De Lima, Thereza C. M.

“…Rationale There is extensive evidence indicating the influence of seizures on emotional responses observed in human and animals, but so far few studies are…”
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The aqueous extracts of Passiflora alata and Passiflora edulis reduce anxiety-related behaviors without affecting memory process in rats by Barbosa, Paulo R, Valvassori, Samira S, Bordignon, Jr, Celso L, Kappel, Virginia D, Martins, Márcio R, Gavioli, Elaine C, Quevedo, João, Reginatto, Flávio H

“…Several species of Passiflora have been employed widely as a folk medicine because of sedative and tranquillizer activities. In this study, we evaluate the…”
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Nociceptin/orphanin FQ receptor system blockade as an innovative strategy for increasing resilience to stress by Gavioli, Elaine C., Holanda, Victor A.D., Calo, Girolamo, Ruzza, Chiara

“…•A complex interplay exists between responses to stress and the N/OFQ-NOP system.•Stress modulates N/OFQ release and NOP expression.•The N/OFQ-NOP system…”
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The NOP antagonist BTRX-246040 increases stress resilience in mice without affecting adult neurogenesis in the hippocampus by D'Oliveira da Silva, Flora, Azevedo Neto, Joaquim, Sturaro, Chiara, Guarino, Annunziata, Robert, Cathaline, Gavioli, Elaine C., Calo, Girolamo, Mouledous, Lionel, Ruzza, Chiara

“…Nociceptin/orphanin FQ (N/OFQ) is the endogenous ligand of an inhibitory G protein coupled receptor named N/OFQ peptide receptor (NOP). Clinical and…”
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Activation of NOP receptor increases vulnerability to stress: role of glucocorticoids and CRF signaling by Holanda, Victor A. D., de Almeida, Raissa N., de Oliveira, Matheus C, da Silva Junior, Edilson D., Galvão-Coelho, Nicole L., Calo’, Girolamo, Ruzza, Chiara, Gavioli, Elaine C.

“…Rationale Recently, we demonstrated that the activation of the nociceptin/orphanin FQ (N/OFQ) receptor (NOP) signaling facilitates depressive-like behaviors…”
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The alpha1A antagonist tamsulosin impairs memory acquisition, consolidation and retrieval in a novel object recognition task in mice by Holanda, Victor A.D., Oliveira, Matheus C., de Oliveira Torres, Carina I., de Almeida Moura, Clarissa, Belchior, Hindiael, da Silva Junior, Edilson D., Gavioli, Elaine C.

“…Tamsulosin is an α1-adrenoceptor antagonist used to treat benign prostatic hyperplasia. This drug exhibits high affinity for α1A- and α1D-adrenoceptor…”
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Tamsulosin facilitates depressive-like behaviors in mice: Involvement of endogenous glucocorticoids by Holanda, Victor A.D., Oliveira, Matheus C., da Silva Junior, Edilson D., Gavioli, Elaine C.

“…The benign prostatic hyperplasia (BPH) is the main source of lower urinary tract symptoms. The BPH is a common age‐dependent disease and tamsulosin is an…”
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Neuropeptide S reduces mouse aggressiveness in the resident/intruder test through selective activation of the neuropeptide S receptor by Ruzza, Chiara, Asth, Laila, Guerrini, Remo, Trapella, Claudio, Gavioli, Elaine C.

“…Neuropeptide S (NPS) regulates various biological functions by selectively activating the NPS receptor (NPSR). In particular NPS evokes robust anxiolytic-like…”
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Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness by Holanda, Victor A. D., Medeiros, Iris U., Asth, Laila, Guerrini, Remo, Calo’, Girolamo, Gavioli, Elaine C.

“…Rationale Pharmacological and genetic evidence support antidepressant-like effects elicited by the blockade of the NOP receptor. The learned helplessness (LH)…”
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In vitro and in vivo pharmacological characterization of the nociceptin/orphanin FQ receptor ligand Ac-RYYRIK-ol by Gündüz, Özge, Rizzi, Anna, Baldisserotto, Anna, Guerrini, Remo, Spagnolo, Barbara, Gavioli, Elaine C., Kocsis, László, Magyar, Anna, Benyhe, Sándor, Borsodi, Anna, Calò, Girolamo

“…It was recently reported that the hexapeptide Ac-RYYRIK-ol binds with high affinity nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptors and competitively…”
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Blockade of NOP receptor modulates anxiety-related behaviors in mice exposed to inescapable stress by Silva, Aldemara I., Holanda, Victor A.D., Azevedo Neto, Joaquim G., Silva Junior, Edilson D., Soares-Rachetti, Vanessa P., Calo, Girolamo, Ruzza, Chiara, Gavioli, Elaine C.

“…Rationale Depression and anxiety frequently co-occur, and this has important clinical implications. Previous studies showed that activation of the…”
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