Search Results - "Gavin W. G. Wilkinson"

High-resolution human cytomegalovirus transcriptome by Gatherer, Derek, Seirafian, Sepehr, Cunningham, Charles, Holton, Mary, Dargan, Derrick J, Baluchova, Katarina, Hector, Ralph D, Galbraith, Julie, Herzyk, Pawel, Wilkinson, Gavin W. G, Davison, Andrew J

“…Deep sequencing was used to bring high resolution to the human cytomegalovirus (HCMV) transcriptome at the stage when infectious virion production is under…”
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Human cytomegalovirus: taking the strain by Wilkinson, Gavin W. G., Davison, Andrew J., Tomasec, Peter, Fielding, Ceri A., Aicheler, Rebecca, Murrell, Isa, Seirafian, Sepher, Wang, Edward C. Y., Weekes, Michael, Lehner, Paul J., Wilkie, Gavin S., Stanton, Richard J.

“…In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV), we reflect on the merits and limitations of the viral strains…”
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High-throughput sequence analysis of variants of human cytomegalovirus strains Towne and AD169 by Bradley, Amanda J, Lurain, Nell S, Ghazal, Peter, Trivedi, Urmi, Cunningham, Charles, Baluchova, Katarina, Gatherer, Derek, Wilkinson, Gavin W. G, Dargan, Derrick J, Davison, Andrew J

“…1 MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK 2 Department of Immunology and Microbiology, Rush University Medical Center,…”
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Genetic content of wild-type human cytomegalovirus by Dolan, Aidan, Cunningham, Charles, Hector, Ralph D, Hassan-Walker, Aycan F, Lee, Lydia, Addison, Clare, Dargan, Derrick J, McGeoch, Duncan J, Gatherer, Derek, Emery, Vincent C, Griffiths, Paul D, Sinzger, Christian, McSharry, Brian P, Wilkinson, Gavin W. G, Davison, Andrew J

“…1 MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK 2 Department of Virology, Royal Free and University College Medical School,…”
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Human cytomegalovirus UL40 signal peptide regulates cell surface expression of the NK cell ligands HLA-E and gpUL18 by Prod'homme, Virginie, Tomasec, Peter, Cunningham, Charles, Lemberg, Marius K, Stanton, Richard J, McSharry, Brian P, Wang, Eddie C Y, Cuff, Simone, Martoglio, Bruno, Davison, Andrew J, Braud, Véronique M, Wilkinson, Gavin W G

“…Human CMV (HCMV)-encoded NK cell-evasion functions include an MHC class I homolog (UL18) with high affinity for the leukocyte inhibitory receptor-1 (CD85j,…”
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Adenovirus E3/19K Promotes Evasion of NK Cell Recognition by Intracellular Sequestration of the NKG2D Ligands Major Histocompatibility Complex Class I Chain-Related Proteins A and B by MCSHARRY, Brian P, BURGERT, Hans-Gerhard, LITTLE, Ann-Margaret, WANG, Eddie C. Y, TOMASEC, Peter, WILKINSON, Gavin W. G, OWEN, Douglas P, STANTON, Richard J, PROD'HOMME, Virginie, SESTER, Martina, KOEBERNICK, Katja, GROH, Veronika, SPIES, Thomas, COX, Steven

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112 by Prod'homme, Virginie, Sugrue, Daniel M, Stanton, Richard J, Nomoto, Akio, Davies, James, Rickards, Carole R, Cochrane, Daniel, Moore, Melanie, Wilkinson, Gavin W G, Tomasec, Peter

“…Human cytomegalovirus (HCMV) UL141 induces protection against natural killer cell-mediated cytolysis by downregulating cell surface expression of CD155…”
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The Human Cytomegalovirus MHC Class I Homolog UL18 Inhibits LIR-1+ but Activates LIR-1- NK Cells by Prod'homme, Virginie, Griffin, Cora, Aicheler, Rebecca J, Wang, Eddie C. Y, McSharry, Brian P, Rickards, Carole R, Stanton, Richard J, Borysiewicz, Leszek K, Lopez-Botet, Miguel, Wilkinson, Gavin W. G, Tomasec, Peter

“…The inhibitory leukocyte Ig-like receptor 1 (LIR-1, also known as ILT2, CD85j, or LILRB1) was identified by its high affinity for the human CMV (HCMV) MHC…”
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Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy by Holcakova, Jitka, Muller, Petr, Tomasec, Peter, Hrstka, Roman, Nekulova, Marta, Krystof, Vladimir, Strnad, Miroslav, Wilkinson, Gavin W G, Vojtesek, Borivoj

“…Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are…”
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Abrogation of the interferon response promotes more efficient human cytomegalovirus replication by McSharry, Brian P, Forbes, Simone K, Avdic, Selmir, Randall, Richard E, Wilkinson, Gavin W G, Abendroth, Allison, Slobedman, Barry

“…The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to…”
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IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection by Stacey, Maria A, Marsden, Morgan, Wang, Eddie C Y, Wilkinson, Gavin W G, Humphreys, Ian R

“…IL-10 is an immunomodulatory cytokine that acts to antagonize T cell responses elicited during acute and chronic infections. Thus, the IL-10R signaling pathway…”
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Surface Expression of HLA-E, An Inhibitor of Natural Killer Cells, Enhanced by Human Cytomegalovirus gpUL40 by Tomasec, Peter, Braud, Veronique M., Rickards, Carole, Powell, Martin B., McSharry, Brian P., Gadola, Stephan, Cerundolo, Vincenzo, Borysiewicz, Leszek K., McMichael, Andrew J., Gavin W. G. Wilkinson

“…The nonclassical major histocompatibility complex (MHC) class I molecule HLA-E inhibits natural killer (NK) cell-mediated lysis by interacting with CD94/NKG2A…”
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Human Cytomegalovirus Encodes an MHC Class I-Like Molecule (UL142) That Functions to Inhibit NK Cell Lysis by Wills, Mark R, Ashiru, Omodele, Reeves, Matthew B, Okecha, Georgina, Trowsdale, John, Tomasec, Peter, Wilkinson, Gavin W. G, Sinclair, John, Sissons, J. G. Patrick

“…Clinical and low passage strains of human CMV (HCMV) encode an additional MHC class I-related molecule UL142, in addition to the previously described UL18. The…”
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Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation by Fielding, Ceri A, Aicheler, Rebecca, Stanton, Richard J, Wang, Eddie C Y, Han, Song, Seirafian, Sepehr, Davies, James, McSharry, Brian P, Weekes, Michael P, Antrobus, P Robin, Prod'homme, Virginie, Blanchet, Fabien P, Sugrue, Daniel, Cuff, Simone, Roberts, Dawn, Davison, Andrew J, Lehner, Paul J, Wilkinson, Gavin W G, Tomasec, Peter

“…NKG2D plays a major role in controlling immune responses through the regulation of natural killer (NK) cells, αβ and γδ T-cell function. This activating…”
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Plasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141 by Hsu, Jye-Lin, van den Boomen, Dick J H, Tomasec, Peter, Weekes, Michael P, Antrobus, Robin, Stanton, Richard J, Ruckova, Eva, Sugrue, Daniel, Wilkie, Gavin S, Davison, Andrew J, Wilkinson, Gavin W G, Lehner, Paul J

“…Human cytomegalovirus (HCMV) US2, US3, US6 and US11 act in concert to prevent immune recognition of virally infected cells by CD8+ T-lymphocytes through…”
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Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens by Cunningham, Charles, Gatherer, Derek, Hilfrich, Birgitta, Baluchova, Katarina, Dargan, Derrick J, Thomson, Marian, Griffiths, Paul D, Wilkinson, Gavin W. G, Schulz, Thomas F, Davison, Andrew J

“…1 MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK 2 Institute of Virology, Hannover Medical School,…”
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Sequential mutations associated with adaptation of human cytomegalovirus to growth in cell culture by Dargan, Derrick J, Douglas, Elaine, Cunningham, Charles, Jamieson, Fiona, Stanton, Richard J, Baluchova, Katarina, McSharry, Brian P, Tomasec, Peter, Emery, Vincent C, Percivalle, Elena, Sarasini, Antonella, Gerna, Giuseppe, Wilkinson, Gavin W G, Davison, Andrew J

“…Mutations that occurred during adaptation of human cytomegalovirus to cell culture were monitored by isolating four strains from clinical samples, passaging…”
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Re-engineering adenovirus vector systems to enable high-throughput analyses of gene function by Stanton, Richard J, McSharry, Brian P, Armstrong, Melanie, Tomasec, Peter, Wilkinson, Gavin W G

“…With the enhanced capacity of bioinformatics to interrogate extensive banks of sequence data, more efficient technologies are needed to test gene function…”
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Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions by Nobre, Luis V, Nightingale, Katie, Ravenhill, Benjamin J, Antrobus, Robin, Soday, Lior, Nichols, Jenna, Davies, James A, Seirafian, Sepehr, Wang, Eddie Cy, Davison, Andrew J, Wilkinson, Gavin Wg, Stanton, Richard J, Huttlin, Edward L, Weekes, Michael P

“…Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly…”
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Modulation of natural killer cells by human cytomegalovirus by Wilkinson, Gavin W.G, Tomasec, Peter, Stanton, Richard J, Armstrong, Melanie, Prod’homme, Virginie, Aicheler, Rebecca, McSharry, Brian P, Rickards, Carole R, Cochrane, Daniel, Llewellyn-Lacey, Sian, Wang, Eddie C.Y, Griffin, Cora A, Davison, Andrew J

“…Abstract Human cytomegalovirus (HCMV) causes lifelong, persistent infections and its survival is under intense, continuous selective pressure from the immune…”
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