Search Results - "Gavilondo, Jorge V"
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Antibody engineering at the millennium
Published in BioTechniques (01-07-2000)“…It has been almost 100 years since von Behring and Kitasato received the first Nobel prize for the discovery of passive immunotherapy and nearly 25 years since…”
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2
Specific humoral and cellular immune responses in cancer patients undergoing chronic immunization with a VEGF-based therapeutic vaccine
Published in Vaccine (16-06-2017)“…Highlights • Specific immune response after chronic immunization with CIGB-247 was studied. • We evaluated eight patients after three years of vaccinations. •…”
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3
Expression and characterization of an anti-(hepatitis B surface antigen) glycosylated mouse antibody in transgenic tobacco (Nicotiana tabacum) plants and its use in the immunopurification of its target antigen
Published in Biotechnology and applied biochemistry (01-12-2003)“…Transgenic plants expressing recombinant immunoglobulins have arisen as an alternative technology for the large-scale production of antibodies useful in…”
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4
HCV core protein localizes in the nuclei of nonparenchymal liver cells from chronically HCV-infected patients
Published in Biochemical and biophysical research communications (22-04-2005)“…Understanding the mechanism of hepatitis C virus (HCV) pathogenesis is an important part of HCV research. Recent experimental evidence suggests that the HCV…”
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5
Specific active immunotherapy with the HEBERSaVax VEGF-based cancer vaccine: From bench to bedside
Published in Seminars in oncology (01-01-2018)“…HEBERSaVax is a cancer therapeutic vaccine candidate based on the combination of a recombinant antigen representative of human vascular endothelial growth…”
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CIGB-247: A VEGF-based therapeutic vaccine that reduces experimental and spontaneous lung metastasis of C57Bl/6 and BALB/c mouse tumors
Published in Vaccine (27-02-2012)“…Highlights ► Antimetastatic effects of a VEGF based active immunotherapy: CIGB-247. ► CIGB-247 is a cancer therapeutic, based on recombinant modified VEGF as…”
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Vaccination with a mutated variant of human Vascular Endothelial Growth Factor (VEGF) blocks VEGF-induced retinal neovascularization in a rabbit experimental model
Published in Experimental eye research (01-05-2014)“…Vascular Endothelial Growth Factor (VEGF) is a key driver of the neovascularization and vascular permeability that leads to the loss of visual acuity of eye…”
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Affinity maturation and fine functional mapping of an antibody fragment against a novel neutralizing epitope on human vascular endothelial growth factor
Published in Molecular bioSystems (01-08-2013)“…We have previously reported the isolation of a novel single-chain variable fragment (scFv) against vascular endothelial growth factor (VEGF), from a…”
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Isolation of a novel neutralizing antibody fragment against human vascular endothelial growth factor from a phage-displayed human antibody repertoire using an epitope disturbing strategy
Published in Journal of biotechnology (20-01-2011)“…Following the clinical success of Bevacizumab, a humanized monoclonal antibody that blocks the interaction between vascular endothelial growth factor (VEGF)…”
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10
Antigen dose escalation study of a VEGF-based therapeutic cancer vaccine in non human primates
Published in Vaccine (05-01-2012)“…Highlights ► CIGB-247 is a cancer therapeutic, based on recombinant modified VEGF as antigen, in combination with powerful adjuvant VSSP. ► We extend the…”
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Immunogenicity and some safety features of a VEGF-based cancer therapeutic vaccine in rats, rabbits and non-human primates
Published in Vaccine (26-04-2010)“…Abstract We have developed a cancer vaccine candidate (hereafter denominated CIGB-247), based on recombinant modified human vascular endothelial growth factor…”
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Characteristics of the specific humoral response in patients with advanced solid tumors after active immunotherapy with a VEGF vaccine, at different antigen doses and using two distinct adjuvants
Published in BMC immunology (26-07-2017)“…CIGB-247, a VSSP-adjuvanted VEGF-based vaccine, was evaluated in a phase I clinical trial in patients with advanced solid tumors (CENTAURO). Vaccination with…”
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Anti-tumoral effect of active immunotherapy in C57BL/6 mice using a recombinant human VEGF protein as antigen and three chemically unrelated adjuvants
Published in Angiogenesis (London) (01-12-2008)“…Following the clinical success of Bevacizumab, a humanized monoclonal antibody that affects the interaction between vascular endothelial growth factor (VEGF)…”
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14
Experimental studies of a vaccine formulation of recombinant human VEGF antigen with aluminum phosphate
Published in Human vaccines & immunotherapeutics (03-08-2015)“…CIGB-247 is a cancer vaccine that is a formulation of a recombinant protein antigen representative of the human vascular endothelial growth factor (VEGF) with…”
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Comparative in vitro and experimental in vivo studies of the anti-epidermal growth factor receptor antibody nimotuzumab and its aglycosylated form produced in transgenic tobacco plants
Published in Plant biotechnology journal (01-01-2013)“…A broad variety of foreign genes can be expressed in transgenic plants, which offer the opportunity for large-scale production of pharmaceutical proteins, such…”
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An integral approach towards a practical application for a plant-made monoclonal antibody in vaccine purification
Published in Vaccine (07-03-2005)“…The use of transgenic plants for the production of pharmaceutical compounds has received increasing attention in the last few years. However, many…”
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Journal Article Conference Proceeding -
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Transient expression in tobacco leaves of an aglycosylated recombinant antibody against the epidermal growth factor receptor
Published in Biotechnology and bioengineering (20-01-2005)“…When generating stably transformed transgenic plants, transient gene expression experiments are especially useful to rapidly confirm that the foreign molecule…”
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Phase I clinical trial of the (131)I-labeled anticarcinoembryonic antigen CIGB-M3 multivalent antibody fragment
Published in Cancer biotherapy & radiopharmaceuticals (01-06-2011)“…Center for Genetic Engineering and Biotechnology (CIGB)-M3 is a trivalent recombinant single-chain Fv antibody fragment specific for carcinoembryonic antigen…”
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Efficient construction of a highly useful phage-displayed human antibody repertoire
Published in Biochemical and biophysical research communications (04-11-2005)“…We have constructed a highly useful phage-displayed human antibody repertoire with limited cloning efforts. Our strategy was to maximize diversity during the…”
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Prophylactic naked DNA vaccination with the human vascular endothelial growth factor induces an anti-tumor response in C57Bl/6 mice
Published in Angiogenesis (London) (01-03-2007)“…Passive immunotherapy against soluble pro-angiogenic factors and/or their receptors in endothelial cells has become a promising approach in cancer…”
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