Search Results - "Gavilán, María P."
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Cytoskeleton and Golgi-apparatus interactions: a two-way road of function and structure
Published in Cell health and cytoskeleton (01-01-2015)“…The Golgi apparatus is the result of a complex and dynamic interaction between a large variety of molecules that determine its architecture, protein and lipid…”
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The dual role of the centrosome in organizing the microtubule network in interphase
Published in EMBO reports (01-11-2018)“…Here, we address the regulation of microtubule nucleation during interphase by genetically ablating one, or two, of three major mammalian γ‐TuRC‐binding…”
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Disconnecting the Golgi ribbon from the centrosome prevents directional cell migration and ciliogenesis
Published in The Journal of cell biology (30-05-2011)“…Mammalian cells exhibit a frequent pericentrosomal Golgi ribbon organization. In this paper, we show that two AKAP450 N-terminal fragments, both containing the…”
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Numb/Numbl-Opo Antagonism Controls Retinal Epithelium Morphogenesis by Regulating Integrin Endocytosis
Published in Developmental cell (16-10-2012)“…Polarized trafficking of adhesion receptors plays a pivotal role in controlling cellular behavior during morphogenesis. Particularly, clathrin-dependent…”
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Nucleus-translocated mitochondrial cytochrome c liberates nucleophosmin-sequestered ARF tumor suppressor by changing nucleolar liquid–liquid phase separation
Published in Nature structural & molecular biology (01-10-2022)“…The regular functioning of the nucleolus and nucleus-mitochondria crosstalk are considered unrelated processes, yet cytochrome c (C c ) migrates to the nucleus…”
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Alpha-catenin-dependent recruitment of the centrosomal protein CAP350 to adherens junctions allows epithelial cells to acquire a columnar shape
Published in PLoS biology (01-03-2015)“…Epithelial morphogenesis involves a dramatic reorganisation of the microtubule cytoskeleton. How this complex process is controlled at the molecular level is…”
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7
Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus
Published in Journal of neuroinflammation (04-05-2012)“…Neuroinflammation and protein accumulation are characteristic hallmarks of both normal aging and age-related neurodegenerative diseases. However, the…”
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Inhibition of the PP2A activity by the histone chaperone ANP32B is long-range allosterically regulated by respiratory cytochrome c
Published in Redox biology (01-07-2021)“…Repair of injured DNA relies on nucleosome dismantling by histone chaperones and de-phosphorylation events carried out by Protein Phosphatase 2A (PP2A)…”
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Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus
Published in Open biology (01-06-2018)“…Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these…”
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Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress
Published in Neurobiology of aging (01-05-2015)“…Abstract Autophagy plays a key role in the maintenance of cellular homeostasis, and autophagy deregulation gives rise to severe disorders. Many of the…”
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CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia
Published in Cell reports methods (23-10-2023)“…Decades of research have not yet fully explained the mechanisms of epithelial self-organization and 3D packing. Single-cell analysis of large 3D epithelial…”
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Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1
Published in Journal of cell science (01-07-2013)“…Spatiotemporal regulation of mitotic kinase activity underlies the extensive rearrangement of cellular components required for cell division. One highly…”
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Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading via FHOD1
Published in Journal of cell science (01-01-2013)“…Spatiotemporal regulation of mitotic kinase activity underlies the extensive rearrangement of cellular components required for cell division. One highly…”
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14
Alpha-catenin-Dependent Recruitment of the Centrosomal Protein CAP350 to Adherens Junctions Allows Epithelial Cells to Acquire a Columnar Shape: e1002087
Published in PLoS biology (01-03-2015)“…Epithelial morphogenesis involves a dramatic reorganisation of the microtubule cytoskeleton. How this complex process is controlled at the molecular level is…”
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