Search Results - "Gavard, Angeline E"

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition by Yosaatmadja, Yuliana, Baddock, Hannah T, Newman, Joseph A, Bielinski, Marcin, Gavard, Angeline E, Mukhopadhyay, Shubhashish M M, Dannerfjord, Adam A, Schofield, Christopher J, McHugh, Peter J, Gileadi, Opher

“…Abstract Artemis (SNM1C/DCLRE1C) is an endonuclease that plays a key role in development of B- and T-lymphocytes and in dsDNA break repair by non-homologous…”
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The crystal structure of human forkhead box N1 in complex with DNA reveals the structural basis for forkhead box family specificity by Newman, Joseph A., Aitkenhead, Hazel, Gavard, Angeline E., Rota, Ioanna A., Handel, Adam E., Hollander, Georg A., Gileadi, Opher

“…Forkhead box N1 (FOXN1) is a member of the forkhead box family of transcription factors and plays an important role in thymic epithelial cell differentiation…”
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Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers by Newman, Joseph A, Gavard, Angeline E, Lieb, Simone, Ravichandran, Madhwesh C, Hauer, Katja, Werni, Patrick, Geist, Leonhard, Böttcher, Jark, Engen, John R, Rumpel, Klaus, Samwer, Matthias, Petronczki, Mark, Gileadi, Opher

“…Loss of WRN, a DNA repair helicase, was identified as a strong vulnerability of microsatellite instable (MSI) cancers, making WRN a promising drug target. We…”
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