Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates

Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates

The increasing prevalence of poorly soluble drugs in development provides notable risk of new products demonstrating low and erratic bioavailabilty with consequences for safety and efficacy, particularly for drugs delivered by the oral route of administration. Although numerous strategies exist for...

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Bibliographic Details
Published in:Advanced drug delivery reviews Vol. 59; no. 7; pp. 617 - 630
Main Authors: Blagden, N., de Matas, M., Gavan, P.T., York, P.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 30-07-2007
Subjects:
Biological Availability
Chemistry, Pharmaceutical
Co-crystals
Crystal engineering
Crystallisation
Crystallization
Dissolution rate
Drug Design
Pharmaceutical Preparations - chemistry
Polymorphism
Solubility
Solvents - chemistry
Supramolecular chemistry
Crystal engineering
Crystallisation
Co-crystals
Dissolution rate
Solubility
Supramolecular chemistry
Polymorphism
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Description
Summary:The increasing prevalence of poorly soluble drugs in development provides notable risk of new products demonstrating low and erratic bioavailabilty with consequences for safety and efficacy, particularly for drugs delivered by the oral route of administration. Although numerous strategies exist for enhancing the bioavailability of drugs with low aqueous solubility, the success of these approaches is not yet able to be guaranteed and is greatly dependent on the physical and chemical nature of the molecules being developed. Crystal engineering offers a number of routes to improved solubility and dissolution rate, which can be adopted through an in-depth knowledge of crystallisation processes and the molecular properties of active pharmaceutical ingredients. This article covers the concept and theory of crystal engineering and discusses the potential benefits, disadvantages and methods of preparation of co-crystals, metastable polymorphs, high-energy amorphous forms and ultrafine particles. Also considered within this review is the influence of crystallisation conditions on crystal habit and particle morphology with potential implications for dissolution and oral absorption.
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ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2007.05.011