Search Results - "Gautvik, Vigdis T."

Distinct DNA methylation profiles in bone and blood of osteoporotic and healthy postmenopausal women by Reppe, Sjur, Lien, Tonje G., Hsu, Yi-Hsiang, Gautvik, Vigdis T., Olstad, Ole K., Yu, Rona, Bakke, Hege G., Lyle, Robert, Kringen, Marianne K., Glad, Ingrid K., Gautvik, Kaare M.

“…DNA methylation affects expression of associated genes and may contribute to the missing genetic effects from genome-wide association studies of osteoporosis…”
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Mechanical-Stress-Related Epigenetic Regulation of ZIC1 Transcription Factor in the Etiology of Postmenopausal Osteoporosis by Datta, Harish K, Kringen, Marianne K, Tuck, Stephen P, Salpingidou, Georgia, Olstad, Ole K, Gautvik, Kaare M, Cockell, Simon J, Gautvik, Vigdis T, Prediger, Michael, Wu, Jun Jie, Birch, Mark A, Reppe, Sjur

“…Mechanical loading exerts a profound influence on bone density and architecture, but the exact mechanism is unknown. Our study shows that expression of the…”
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Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype by Jemtland, Rune, Holden, Marit, Reppe, Sjur, Olstad, Ole K, Reinholt, Finn P, Gautvik, Vigdis T, Refvem, Hilde, Frigessi, Arnoldo, Houston, Brian, Gautvik, Kaare M

“…Genome‐wide gene expressions in bone biopsies from patients with postmenopausal osteoporosis and healthy controls were profiled, to identify osteoporosis…”
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Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes by Kalogeropoulos, Michail, Varanasi, Satya S, Olstad, Ole K, Sanderson, Paul, Gautvik, Vigdis T, Reppe, Sjur, Francis, Roger M, Gautvik, Kaare M, Birch, Mark A, Datta, Harish K

“…A transcriptome analysis compared gene expression in human bone biopsy samples taken from lumbar spine and iliac crest, sites that experience high and low…”
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Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone by Fortunati, Dario, Reppe, Sjur, Fjeldheim, Åse-Karine, Nielsen, Marit, Gautvik, Vigdis T., Gautvik, Kaare M.

“…Periostin is a 90kDa secreted protein, originally identified in murine osteoblast-like cells, with a distribution restricted to collagen-rich tissues and…”
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Skeletal site-related variation in human trabecular bone transcriptome and signaling by Varanasi, Satya S, Olstad, Ole K, Swan, Daniel C, Sanderson, Paul, Gautvik, Vigdis T, Reppe, Sjur, Francis, Roger M, Gautvik, Kaare M, Datta, Harish K

“…The skeletal site-specific influence of multiple genes on bone morphology is recognised, but the question as to how these influences may be exerted at the…”
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Methylation of Bone SOST, Its mRNA, and Serum Sclerostin Levels Correlate Strongly With Fracture Risk in Postmenopausal Women by Reppe, Sjur, Noer, Agate, Grimholt, Runa M, Halldórsson, Bjarni V, Medina‐Gomez, Carolina, Gautvik, Vigdis T, Olstad, Ole Kristoffer, Berg, Jens Petter, Datta, Harish, Estrada, Karol, Hofman, Albert, Uitterlinden, André G, Rivadeneira, Fernando, Lyle, Robert, Collas, Philippe, Gautvik, Kaare M

“…ABSTRACT Inhibition of sclerostin, a glycoprotein secreted by osteocytes, offers a new therapeutic paradigm for treatment of osteoporosis (OP) through its…”
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Distinct Subsets of Noncoding RNAs Are Strongly Associated With BMD and Fracture, Studied in Weight‐Bearing and Non–Weight‐Bearing Human Bone by Gautvik, Kaare M, Günther, Clara‐Cecilie, Prijatelj, Vid, Medina‐Gomez, Carolina, Shevroja, Enisa, Rad, Leila Heidary, Yazdani, Mazyar, Lindalen, Einar, Valland, Haldor, Gautvik, Vigdis T, Olstad, Ole K, Holden, Marit, Rivadeneira, Fernando, Utheim, Tor P, Reppe, Sjur

“…ABSTRACT We investigated mechanisms resulting in low bone mineral density (BMD) and susceptibility to fracture by comparing noncoding RNAs (ncRNAs) in biopsies…”
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Eight genes are highly associated with BMD variation in postmenopausal Caucasian women by Reppe, Sjur, Refvem, Hilde, Gautvik, Vigdis T, Olstad, Ole K, Høvring, Per I, Reinholt, Finn P, Holden, Marit, Frigessi, Arnoldo, Jemtland, Rune, Gautvik, Kaare M

“…Abstract Low bone mineral density (BMD) is an important risk factor for skeletal fractures which occur in about 40% of women ≥ 50 years in the western world…”
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Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults by Gautvik, Kaare M, Olstad, Ole K, Raue, Ulrika, Gautvik, Vigdis T, Kvernevik, Karl J, Utheim, Tor P, Ravnum, Solveig, Kirkegaard, Camilla, Wiig, Håvard, Jones, Garan, Pilling, Luke C, Trappe, Scott, Raastad, Truls, Reppe, Sjur

“…A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of…”
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Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice by Nissen-Meyer, Lise Sofie Haug, Jemtland, Rune, Gautvik, Vigdis T, Pedersen, Mona E, Paro, Rita, Fortunati, Dario, Pierroz, Dominique D, Stadelmann, Vincent A, Reppe, Sjur, Reinholt, Finn P, Del Fattore, Andrea, Rucci, Nadia, Teti, Anna, Ferrari, Serge, Gautvik, Kaare M

“…The transcription factor Sox4 is vital for fetal development, as Sox4⁻/⁻ homozygotes die in utero. Sox4 mRNA is expressed in the early embryonic growth plate…”
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Identification of transcriptional macromolecular associations in human bone using browser based in silico analysis in a giant correlation matrix by Reppe, Sjur, Sachse, Daniel, Olstad, Ole K, Gautvik, Vigdis T, Sanderson, Paul, Datta, Harish K, Berg, Jens P, Gautvik, Kaare M

“…Abstract Intracellular signaling is critically dependent on gene regulatory networks comprising physical molecular interactions. Presently, there is a lack of…”
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Overview of the Most Prevalent Hypothalamus-Specific mRNAs, as Identified by Directional Tag PCR Subtraction by Gautvik, Kaare M., De Lecea, Luis, Gautvik, Vigdis T., Danielson, Patria E., Tranque, Pedro, Dopazo, Ana, Bloom, Floyd E., Sutcliffe, J. Gregor

“…We applied the directional tag PCR subtractive hybridization method to construct a rat hypothalamic cDNA library from which cerebellar and hippocampal…”
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Calmodulin-dependent kinase 1β is expressed in the epiphyseal growth plate and regulates proliferation of mouse calvarial osteoblasts in vitro by Pedersen, Mona E, Fortunati, Dario, Nielsen, Marit, Brorson, Sverre-Henning, Lekva, Tove, Nissen-Meyer, Lise Sofie H, Gautvik, Vigdis T, Shahdadfar, Aboulghassem, Gautvik, Kaare M, Jemtland, Rune

“…Abstract The Ca2+ /Calmodulin-dependent protein kinase (CaMK) family is activated in response to elevation of intracellular Ca2+ , and includes CaMK1 (as well…”
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miR-223 is differentially expressed in post menopausal osteoporotic women compared to healthy control females and regulates osteoclastogenesis by Hoevring, Per I, Jemtland, Rune, Olstad, Ole K, Reppe, Sjur, Gautvik, Vigdis T, Gautvik, Kaare M

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Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells by Reppe, Sjur, Olstad, Ole K., Rian, Edith, Gautvik, Vigdis T., Gautvik, Kaare M., Jemtland, Rune

“…Parathyroid hormone (PTH) exerts potent and diverse effects in bone and cartilage through activation of type 1 PTH receptors (PTH1R) capable of coupling to…”
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Sox‐4 Messenger RNA Is Expressed in the Embryonic Growth Plate and Regulated via the Parathyroid Hormone/Parathyroid Hormone‐Related Protein Receptor in Osteoblast‐like Cells by Reppe, Sjur, Rian, Edith, Jemtland, Rune, Olstad, Ole K., Gautvik, Vigdis T., Gautvik, Kaare M.

“…Parathyroid hormone (PTH) and PTH‐related protein (PTHrP) exert potent and diverse effects in cells of the osteoblastic and chondrocytic lineages. However,…”
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Molecular heterogeneity in human osteosarcoma demonstrated by enriched mRNAs isolated by directional tag PCR subtraction cloning by Olstad, Ole K, Gautvik, Vigdis T, Reppe, Sjur, Rian, Edith, Jemtland, Rune, Ohlsson, Claes, Bruland, Oyvind S, Gautvik, Kaare M

“…Directional tag PCR subtractive hybridization was applied to construct a cDNA library generated from three different human osteosarcoma (OS) target cell lines…”
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Efficient secretion of human parathyroid hormone by Saccharomyces cerevisiae by Gabrielsen, O S, Reppe, S, Saether, O, Blingsmo, O R, Sletten, K, Gordeladze, J O, Høgset, A, Gautvik, V T, Alestrøm, P, Oyen, T B

“…A cDNA encoding mature human parathyroid hormone (hPTH) was expressed in Saccharomyces cerevisiae, after fusion to the prepro region of yeast mating factor…”
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Calmodulin-dependent kinase 1beta is expressed in the epiphyseal growth plate and regulates proliferation of mouse calvarial osteoblasts in vitro by Pedersen, Mona E, Fortunati, Dario, Nielsen, Marit, Brorson, Sverre-Henning, Lekva, Tove, Nissen-Meyer, Lise Sofie H, Gautvik, Vigdis T, Shahdadfar, Aboulghassem, Gautvik, Kaare M, Jemtland, Rune

“…The Ca(2+)/Calmodulin-dependent protein kinase (CaMK) family is activated in response to elevation of intracellular Ca(2+), and includes CaMK1 (as well as…”
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