Search Results - "Gauthier, Sebastien A."

Enhanced exosome secretion in Down syndrome brain - a protective mechanism to alleviate neuronal endosomal abnormalities by Gauthier, Sébastien A, Pérez-González, Rocío, Sharma, Ajay, Huang, Fang-Ke, Alldred, Melissa J, Pawlik, Monika, Kaur, Gurjinder, Ginsberg, Stephen D, Neubert, Thomas A, Levy, Efrat

“…A dysfunctional endosomal pathway and abnormally enlarged early endosomes in neurons are an early characteristic of Down syndrome (DS) and Alzheimer's disease…”
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Cystatin C prevents neuronal loss and behavioral deficits via the endosomal pathway in a mouse model of down syndrome by Kaur, Gurjinder, Gauthier, Sebastien A., Perez-Gonzalez, Rocio, Pawlik, Monika, Singh, Amol Bikram, Cosby, Benjamin, Mohan, Panaiyur S., Smiley, John F., Levy, Efrat

“…Cystatin C (CysC) plays diverse protective roles under conditions of neuronal challenge. We investigated whether CysC protects from trisomy-induced pathologies…”
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The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space by Perez-Gonzalez, Rocio, Gauthier, Sebastien A., Kumar, Asok, Levy, Efrat

“…In vitro studies have shown that neuronal cell cultures secrete exosomes containing amyloid-β precursor protein (APP) and the APP-processing products,…”
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Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2 by Gauthier, Sebastien A, VanHaaften, Eric, Cherbas, Lucy, Cherbas, Peter, Hewes, Randall S

“…The ecdysone receptor is a heterodimer of two nuclear receptors, the Ecdysone receptor (EcR) and Ultraspiracle (USP). In Drosophila melanogaster, three EcR…”
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The bHLH protein Dimmed controls neuroendocrine cell differentiation in Drosophila by Hewes, Randall S, Park, Dongkook, Gauthier, Sebastien A, Schaefer, Anneliese M, Taghert, Paul H

“…Neuroendocrine cells are specialized to produce, maintain and release large stores of secretory peptides. We show that the Drosophila dimmed/Mist1 bHLH gene…”
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Neuroprotection mediated by cystatin C-loaded extracellular vesicles by Pérez-González, Rocío, Sahoo, Susmita, Gauthier, Sebastien A., Kim, Yohan, Li, Meihua, Kumar, Asok, Pawlik, Monika, Benussi, Luisa, Ghidoni, Roberta, Levy, Efrat

“…Cystatin C (CysC) is implicated in neuroprotection and repair in the nervous system in response to diverse neurotoxic conditions. In addition to being secreted…”
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A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients by Pérez-González, Rocío, Gauthier, Sébastien A., Sharma, Ajay, Miller, Chelsea, Pawlik, Monika, Kaur, Gurjinder, Kim, Yohan, Levy, Efrat

“…Down syndrome (DS) is characterized by cognitive deficits throughout the life span and with the development of aging-dependent Alzheimer's type neuropathology,…”
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Transcriptional regulation of neuropeptide and peptide hormone expression by the Drosophila dimmed and cryptocephal genes by Gauthier, Sebastien A, Hewes, Randall S

“…The regulation of neuropeptide and peptide hormone gene expression is essential for the development and function of neuroendocrine cells in integrated…”
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Drosophila gain-of-function screen for candidate genes involved in steroid-dependent neuroendocrine cell remodeling by Zhao, T, Gu, T, Rice, H.C, McAdams, K.L, Roark, K.M, Lawson, K, Gauthier, S.A, Reagan, K.L, Hewes, R.S

“…The normal functioning of neuroendocrine systems requires that many neuropeptidergic cells change, to alter transmitter identity and concentration, electrical…”
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Murine cerebrovascular cells as a cell culture model for cerebral amyloid angiopathy: isolation of smooth muscle and endothelial cells from mouse brain by Gauthier, Sebastien A, Sahoo, Susmita, Jung, Sonia S, Levy, Efrat

“…The use of murine cerebrovascular endothelial and smooth muscle cells has not been widely employed as a cell culture model for the investigation of cellular…”
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In vitro assays measuring protection by proteins such as cystatin C of primary cortical neuronal and smooth muscle cells by Gauthier, Sebastien A, Tizon, Belen, Sahoo, Susmita, Levy, Efrat

“…Neuronal cell culture models have been used to demonstrate the protective effects of cystatin C against a variety of insults, including the toxicity induced by…”
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Targeting of a novel fusion protein containing methioninase to the urokinase receptor to inhibit breast cancer cell migration and proliferation by PERON, Karine, JONES, Tara N, GAUTHIER, Sebastien A, NGUYEN, Thao-Nguyen T, ZANG, Xiao-Ping, BARRIERE, Magali, PREVERAUD, Damien, SOLIMAN, Charles E, HARRISON, Roger G, PENTO, J. Thomas

“…It has been shown that methionine depletion inhibits tumor cell growth and reduces tumor cell survival. A novel fusion protein targeted specifically to tumor…”
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