TRIM3, a tumor suppressor linked to regulation of [p21.sup.Waf1/Cip1]

The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in ~20% of human glioblastomas raised the possibility that this NHL-domain con...

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Bibliographic Details
Published in:	Oncogene Vol. 33; no. 3; p. 308
Main Authors:	Liu, Y, Raheja, R, Yeh, N, Ciznadija, D, Pedraza, A.M, Ozawa, T, Hukkelhoven, E, Erdjument-Bromage, H, Tempst, P, Gauthier, N.P, Brennan, C, Holland, E.C, Koff, A
Format:	Journal Article
Language:	English
Published:	Nature Publishing Group 16-01-2014
Subjects:	Cancer Gene expression Genetic aspects Identification and classification Oncology, Experimental Tumor suppressor genes
Online Access:	Get full text
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Summary:	The TRIM family of genes is largely studied because of their roles in development, differentiation and host cell antiviral defenses; however, roles in cancer biology are emerging. Loss of heterozygosity of the TRIM3 locus in ~20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM gene family might be a mammalian tumor suppressor. Consistent with this, reducing TRIM3 expression increased the incidence of and accelerated the development of platelet-derived growth factor-induced glioma in mice. Furthermore, TRIM3 can bind to the cdk inhibitor [p21.sup.WAF1/CIP1]. Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4. Oncogene (2014) 33, 308-315; doi: 10.1038/onc.2012.596; published online 14 January 2013 Keywords: glioma;p21; PDGF; stem/progenitor; TRIM3
ISSN:	0950-9232
DOI:	10.1038/onc.2012.596