Search Results - "Gause, W. C."

Systemic impact of intestinal helminth infections by Mishra, P K, Palma, M, Bleich, D, Loke, P, Gause, W C

“…In this review, we examine the evidence that intestinal helminths can control harmful inflammatory responses and promote homeostasis by triggering systemic…”
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Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni by Wynn, TA, Eltoum, I, Cheever, AW, Lewis, FA, Gause, WC, Sher, A

“…Granulomas induced by parasite eggs are the primary lesions in mice infected with Schistosoma mansoni. Temporal analysis of cytokine mRNA expression in lung…”
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Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection by Morris, SC, Madden, KB, Adamovicz, JJ, Gause, WC, Hubbard, BR, Gately, MK, Finkelman, FD

“…The effects of murine rIL-12 on cytokine gene expression and Ig secretion were studied in vivo. In untreated mice IL-12 enhanced IFN-gamma and IL-10 gene…”
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Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion by Finkelman, FD, Lees, A, Birnbaum, R, Gause, WC, Morris, SC

“…Dendritic cells (DC) are unmatched among APCs in their ability to bind, process, and present Ag. Presentation by such potent APCs, if always immunogenic and…”
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Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response by Mishra, P K, Patel, N, Wu, W, Bleich, D, Gause, W C

“…Helminth infection can prevent type 1 diabetes (T1D); however, the regulatory mechanisms inhibiting disease remain largely undefined. In these studies,…”
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A primary intestinal helminthic infection rapidly induces a gut- associated elevation of Th2-associated cytokines and IL-3 by Svetic, A, Madden, KB, Zhou, XD, Lu, P, Katona, IM, Finkelman, FD, Urban, JF, Jr, Gause, WC

“…The immune response that is characteristic of parasitic helminth infections includes components associated with immediate-type hypersensitivity: elevated serum…”
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Correction of Accelerated Autoimmune Disease by Early Replacement of the Mutated lpr Gene with the Normal Fas Apoptosis Gene in the T Cells of Transgenic MRL-lpr/lpr Mice by Wu, Jianguo, Zhou, Tong, Zhang, Jinju, He, Jin, Gause, William C., Mountz, John D.

“…MRL-lpr/lpr mice develop a generalized autoimmune disease which includes increased autoantibody production, glomerulonephritis, and development of…”
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Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites by FINKELMAN, F. D, MADDEN, K. B, CHEEVER, A. W, KATONA, I. M, MORRIS, S. C, GATELY, M. K, HUBBARD, B. R, GAUSE, W. C, URBAN, J. F

“…The cytokine interleukin (IL) 12 stimulates T cell and natural killer cell production of interferon (IFN) gamma and inhibits T cell production of IL-4. We…”
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The importance of Th2 cytokines in protective immunity to nematodes by Urban, Jr, J F, Madden, K B, Svetić, A, Cheever, A, Trotta, P P, Gause, W C, Katona, I M, Finkelman, F D

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Brucella abortus induces a novel cytokine gene expression pattern characterized by elevated IL-10 and IFN-gamma in CD4+ T cells by Svetić, A, Jian, Y C, Lu, P, Finkelman, F D, Gause, W C

“…Immunization of BALB/c mice with killed Brucella abortus (BA) has previously been shown to increase serum IgG2a levels and long-term T cell clones from these…”
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Mouse Running Activity Is Lowered by Brucella abortus Treatment: A Potential Model to Study Chronic Fatigue by Ottenweller, J.E, Natelson, B.H, Gause, W.C, Carroll, K.K, Beldowicz, D, Zhou, X.D, LaManca, J.J

“…Chronic fatigue syndrome, which can occur after acute infection and last for years, is characterized by severe and persistent fatigue. Others have reported…”
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Immunity to parasitic infections at mucous‐protected environmental interfaces by Gause, W. C., Wilson, M. S.

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Differential effect of CTLA4Ig on murine graft-versus-host disease (GVHD) development: CTLA4Ig prevents both acute and chronic GVHD development but reverses only chronic GVHD by Via, CS, Rus, V, Nguyen, P, Linsley, P, Gause, WC

“…The role of costimulation was examined in an in vivo model of alloantigen-driven Th1 or Th2 cytokine responses, the parent-into-F1 model of acute or chronic…”
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Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody by Svetic, A, Finkelman, FD, Jian, YC, Dieffenbach, CW, Scott, DE, McCarthy, KF, Steinberg, AD, Gause, WC

“…Cytokines are important mediators of effector lymphoid cell function during an immune response, but their expression during an in vivo immune response has not…”
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B7 Requirements for Primary and Secondary Protein- and Polysaccharide-Specific Ig Isotype Responses to Streptococcus pneumoniae by Wu, Zheng-Qi, Khan, Abdul Q, Shen, Yi, Schartman, Jerome, Peach, Robert, Lees, Andrew, Mond, James J, Gause, William C, Snapper, Clifford M

“…The requirements for B7 costimulation during an in vivo humoral response to an intact extracellular bacteria have not been reported. In this study we immunized…”
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B7-2 Is Required for the Progression But Not the Initiation of the Type 2 Immune Response to a Gastrointestinal Nematode Parasite by Greenwald, R. J, Urban, J. F, Ekkens, M. J, Chen, S.-J, Nguyen, D, Fang, H, Finkelman, F. D, Sharpe, A. H, Gause, W. C

“…T cells require CD28/CTLA-4 costimulatory molecule interactions in addition to Ag-specific signals through the TCR for in vivo effector Th cell function. Some…”
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Regulation by interferon α immunoglobulin isotype selection and lymphokine production in mice by FINKELMAN, F. D, SVETIC, A, GRESSER, I, SNAPPER, C, HOLMES, J, TROTTA, P. P, KATONA, I. M, GAUSE, W. C

“…Antigens and infectious agents that stimulate interferon alpha(IFN-alpha) production in mice induce antibody responses that are predominantly of the…”
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CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite by PIN LU, XIA DI ZHOU, CHEN, S.-J, MOORMAN, M, MORRIS, S. C, FINKELMAN, F. D, LINSLEY, P, URBAN, J. F, GAUSE, W. C

“…The costimulatory signal provided to T cells through CTLA-4-ligand interactions is required for T cell activation resulting in increased interleukin 2 (IL-2)…”
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Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways by Jankovic, Dragana, Liu, Zhugong, Gause, William C.

“…The development of T helper 1 (Th1) versus Th2 cells is a major branch point in the immune response. It is an important determinant of whether the response to…”
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The immune response to parasitic helminths: insights from murine models by Gause, William C., Urban, Joseph F., Stadecker, Miguel J.

“…Helminth parasites are a large group of multicellular organisms that affect vast numbers of humans and are a major cause of disease. Several relevant…”
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