Search Results - "Gaukroger, Keira"

Novel Syntheses of Cis and Trans Isomers of Combretastatin A-4 by Gaukroger, Keira, Hadfield, John A, Hepworth, Lucy A, Lawrence, Nicholas J, McGown, Alan T

“…A high-yielding, two-step stereoselective synthesis of the anticancer drug (Z)-combretastatin A-4 (1) has been devised. The method uses the Perkin condensation…”
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Structure–Activity Relationships of C-17 Cyano-Substituted Estratrienes as Anticancer Agents by Leese, Mathew P, Jourdan, Fabrice L, Gaukroger, Keira, Mahon, Mary F, Newman, Simon P, Foster, Paul A, Stengel, Chloe, Regis-Lydi, Sandra, Ferrandis, Eric, Fiore, Anna Di, De Simone, Giuseppina, Supuran, Claudiu T, Purohit, Atul, Reed, Michael J, Potter, Barry V. L

“…The synthesis, SAR, and preclinical evaluation of 17-cyanated 2-substituted estra-1,3,5(10)-trienes as anticancer agents are discussed…”
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Structural requirements for the interaction of combretastatins with tubulin: how important is the trimethoxy unit? by Gaukroger, Keira, Hadfield, John A, Lawrence, Nicholas J, Nolan, Steven, McGown, Alan T

“…A series of combretastatins possessing both a trimethoxy unit and other substituents on ring A has been synthesised and tested for cytotoxicity and their…”
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A practical radiosynthesis of a tritium-labelled fluorocombretastatin by Hadfield, John A., Hirst, Nicholas, Gaukroger, Keira, Lawrence, Nicholas J., McGown, Alan T.

“…Zybrestat (combretastatin A‐4 disodium diphosphate) is currently in clinical trials as an antivascular anticancer agent. A similar fluorinated agent has shown…”
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Synthesis and evaluation of double bond substituted combretastatins by Hadfield, John A., Gaukroger, Keira, Hirst, Nicholas, Weston, Anna P., Lawrence, Nicholas J., McGown, Alan T.

“…A series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to…”
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Structure Activity Study of Stilbenes Targeted at Tumour Vasculature by Gaukroger, Keira

“…The combretastatins are stilbenes isolated from the South African tree Combretum caffrum. These agents are characterised by their ability to interact with…”
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