Search Results - "Gaudet, D"

Glial Cells Shape Pathology and Repair After Spinal Cord Injury by Gaudet, Andrew D., Fonken, Laura K.

“…Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he correctly surmised that microglia in pathologic central nervous…”
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Extracellular matrix regulation of inflammation in the healthy and injured spinal cord by Gaudet, Andrew D., Popovich, Phillip G.

“…Throughout the body, the extracellular matrix (ECM) provides structure and organization to tissues and also helps regulate cell migration and intercellular…”
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Control of the Inflammatory Macrophage Transcriptional Signature by miR-155 by Jablonski, Kyle A, Gaudet, Andrew D, Amici, Stephanie A, Popovich, Phillip G, Guerau-de-Arellano, Mireia

“…Inflammatory M1 spectrum macrophages protect from infection but can cause inflammatory disease and tissue damage, whereas alternatively activated/M2 spectrum…”
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Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury by Gaudet, Andrew D, Popovich, Phillip G, Ramer, Matt S

“…In this review, we first provide a brief historical perspective, discussing how peripheral nerve injury (PNI) may have caused World War I. We then consider the…”
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MicroRNAs: Roles in Regulating Neuroinflammation by Gaudet, Andrew D., Fonken, Laura K., Watkins, Linda R., Nelson, Randy J., Popovich, Phillip G.

“…MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and physiological function in all multicellular organisms. Here, the role of miRNAs in…”
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Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPLS447X) gene therapy for lipoprotein lipase deficiency: an open-label trial by Gaudet, D, Méthot, J, Déry, S, Brisson, D, Essiembre, C, Tremblay, G, Tremblay, K, de Wal, J, Twisk, J, van den Bulk, N, Sier-Ferreira, V, van Deventer, S

“…We describe the 2-year follow-up of an open-label trial (CT-AMT-011–01) of AAV1-LPL S447X gene therapy for lipoprotein lipase (LPL) deficiency (LPLD), an…”
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Stress and aging act through common mechanisms to elicit neuroinflammatory priming by Fonken, Laura K., Frank, Matthew G., Gaudet, Andrew D., Maier, Steven F.

“…•Stress and aging can prime neuroinflammatory processes.•Priming can cause pathological neuroinflammation following an immune challenge.•Silent immune…”
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Nitroxidative Signaling Mechanisms in Pathological Pain by Grace, Peter M, Gaudet, Andrew D, Staikopoulos, Vasiliki, Maier, Steven F, Hutchinson, Mark R, Salvemini, Daniela, Watkins, Linda R

“…Tissue injury can initiate bidirectional signaling between neurons, glia, and immune cells that creates and amplifies pain. While the ability for…”
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miR-155 Deletion in Mice Overcomes Neuron-Intrinsic and Neuron-Extrinsic Barriers to Spinal Cord Repair by Gaudet, Andrew D, Mandrekar-Colucci, Shweta, Hall, Jodie C E, Sweet, David R, Schmitt, Philipp J, Xu, Xinyang, Guan, Zhen, Mo, Xiaokui, Guerau-de-Arellano, Mireia, Popovich, Phillip G

“…Axon regeneration after spinal cord injury (SCI) fails due to neuron-intrinsic mechanisms and extracellular barriers including inflammation. microRNA…”
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High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats by Poret, J M, Souza-Smith, F, Marcell, S J, Gaudet, D A, Tzeng, T H, Braymer, H D, Harrison-Bernard, L M, Primeaux, S D

“…Background/Objectives: Expanding visceral adiposity is associated with increased inflammation and increased risk for developing obesity-related comorbidities…”
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Elevated SLC7A2 expression is associated with an abnormal neuroinflammatory response and nitrosative stress in Huntington's disease by Gaudet, Ian D, Xu, Hongyuan, Gordon, Emily, Cannestro, Gianna A, Lu, Michael L, Wei, Jianning

“…We previously identified solute carrier family 7 member 2 (SLC7A2) as one of the top upregulated genes when normal Huntingtin was deleted. SLC7A2 has a high…”
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Diminished circadian rhythms in hippocampal microglia may contribute to age-related neuroinflammatory sensitization by Fonken, Laura K, Kitt, Meagan M, Gaudet, Andrew D, Barrientos, Ruth M, Watkins, Linda R, Maier, Steven F

“…Abstract Aged animals exhibit diminished circadian rhythms, and both aging and circadian disruption sensitize neuroinflammatory responses. Microglia –the…”
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Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury by Gaudet, Andrew D., Ayala, Monica T., Schleicher, Wolfgang E., Smith, Elana J., Bateman, Emily M., Maier, Steven F., Watkins, Linda R.

“…Spinal cord injury (SCI) causes chronic pain in 65% of individuals. Unfortunately, current pain management is inadequate for many SCI patients. Rodent models…”
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Gene expression profiles of recurrent acute pancreatitis risk in severe hypertriglyceridemia by Tremblay, K, Gaudet, D

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Characterization of Methacrylated Type-I Collagen as a Dynamic, Photoactive Hydrogel by Gaudet, Ian D., Shreiber, David I.

“…Type-I collagen is an attractive scaffold material for tissue engineering due to its ability to self-assemble into a fibrillar hydrogel, its innate support of…”
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Methacrylation Induces Rapid, Temperature-Dependent, Reversible Self-Assembly of Type‑I Collagen by Drzewiecki, Kathryn E, Parmar, Avanish S, Gaudet, Ian D, Branch, Jonathan R, Pike, Douglas H, Nanda, Vikas, Shreiber, David I

“…Type-I collagen self-assembles into a fibrillar gel at physiological temperature and pH to provide a cell-adhesive, supportive, structural network. As such, it…”
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Dissection of clinical and gene expression signatures of familial vs multifactorial chylomicronemia by Gaudet, D, Brisson, D, Tremblay, K

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Investigation of LPL independent pathways of TG-rich lipoprotein metabolism in LPL deficiency by Gaudet, D, Brisson, D, Tremblay, K

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DNA methylation variations at CETP and LPL gene promoter loci: New molecular biomarkers associated with blood lipid profile variability by Guay, S.P, Brisson, D, Lamarche, B, Marceau, P, Vohl, M.C, Gaudet, D, Bouchard, L

“…Abstract Background Recent findings suggest that DNA methylation, a well-known epigenetic mechanism, is involved in high-density lipoprotein cholesterol…”
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Galectin-1 in injured rat spinal cord: Implications for macrophage phagocytosis and neural repair by Gaudet, Andrew D., Sweet, David R., Polinski, Nicole K., Guan, Zhen, Popovich, Phillip G.

“…Galectin (Gal)-1 is a small carbohydrate-binding protein and immune modulatory cytokine that is synthesized locally at the site of peripheral nerve injury. In…”
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