Search Results - "Gauchy, J"

An IgM lupus anticoagulant that neutralizes the enhancing effect of phospholipid on purified endothelial thrombomodulin activity--a mechanism for thrombosis by Freyssinet, J M, Wiesel, M L, Gauchy, J, Boneu, B, Cazenave, J P

“…An anticoagulant activity was isolated from the plasma of a patient with a strong lupus-like anticoagulant using gel filtration by high performance liquid…”
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The effect of phospholipids on the activation of protein C by the human thrombin-thrombomodulin complex by Freyssinet, J M, Gauchy, J, Cazenave, J P

“…Human thrombomodulin, an endothelial-cell-membrane glycoprotein, has been purified from placenta by Triton X-100 extraction and by affinity chromatography on…”
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Stability of the thrombin-thrombomodulin complex on the surface of endothelial cells from human saphenous vein or from the cell line EA.hy 926 by Beretz, A, Freyssinet, J M, Gauchy, J, Schmitt, D A, Klein-Soyer, C, Edgell, C J, Cazenave, J P

“…Protein C activation by alpha-thrombin on the surface of endothelial cells depends on an essential membrane-glycoprotein cofactor, thrombomodulin. In the…”
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Activation of human protein C by blood coagulation factor Xa in the presence of anionic phospholipids. Enhancement by sulphated polysaccharides by Freyssinet, J M, Wiesel, M L, Grunebaum, L, Pereillo, J M, Gauchy, J, Schuhler, S, Freund, G, Cazenave, J P

“…The activation of protein C by thrombin is thought to occur at the endothelial cell surface in the presence of an essential membrane glycoprotein cofactor,…”
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The catalytic role of anionic phospholipids in the activation of protein C by factor Xa and expression of its anticoagulant function in human plasma by Freyssinet, J M, Toti-Orfanoudakis, F, Ravanat, C, Grunebaum, L, Gauchy, J, Cazenave, J P, Wiesel, M L

“…Phospholipids bearing a proportion of anionic species such as phosphatidylserine are necessary to promote the anticoagulant potential of the protein C pathway…”
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Interference of blood-coagulation vitamin K-dependent proteins in the activation of human protein C. Involvement of the 4-carboxyglutamic acid domain in two distinct interactions with the thrombin-thrombomodulin complex and with phospholipids by Freyssinet, J.M, Beretz, A, Klein-Soyer, C, Gauchy, J, Schuhler, S, Cazenave, J.P

“…Human protein C is the precursor of a serine proteinase in plasma which contains nine 4-carboxyglutamic acid residues and functions as a potent anticoagulant…”
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Coextraction of thrombomodulin and tissue factor from human placenta: effects of concanavalin A and phospholipid environment on activity by Freyssinet, J M, Brami, B, Gauchy, J, Cazenave, J P

“…Thrombomodulin and tissue factor activities have been co-extracted from human placenta by several non-ionic detergents, n-octylglucoside and Triton X-100 being…”
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Thrombomodulin activity is found in tissue thromboplastin preparations from placenta and from lung but not from brain by Freyssinet, J M, Gauchy, J, Spaethe, R, Cazenave, J P

“…Substantial thrombomodulin activity could be detected in tissue thromboplastin preparations from placenta or from lung but not from brain. When the amount of…”
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