Search Results - "Gaucher, Geneviève"

Effect of Poly(N-vinyl-pyrrolidone)-block-poly(d,l-lactide) as Coating Agent on the Opsonization, Phagocytosis, and Pharmacokinetics of Biodegradable Nanoparticles by Gaucher, Geneviève, Asahina, Kinji, Wang, Jiaohong, Leroux, Jean-Christophe

“…The effect of the coating polymer poly(N-vinyl-pyrrolidone) (PVP) on the protein adsorption, phagocytosis, and pharmacokinetics of poly(D,L-lactide)-based…”
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Block copolymer micelles: preparation, characterization and application in drug delivery by Gaucher, Geneviève, Dufresne, Marie-Hélène, Sant, Vinayak P., Kang, Ning, Maysinger, Dusica, Leroux, Jean-Christophe

“…Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or oppositely charged copolymers in aqueous medium. The hydrophilic…”
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Polyester-based micelles and nanoparticles for the parenteral delivery of taxanes by Gaucher, Geneviève, Marchessault, Robert H., Leroux, Jean-Christophe

“…Taxanes are potent antimitotic agents that have demonstrated efficacy in a wide range of malignancies. Due to their poor water-solubility, these cytostatic…”
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Polymeric micelles for oral drug delivery by Gaucher, Geneviève, Satturwar, Prashant, Jones, Marie-Christine, Furtos, Alexandra, Leroux, Jean-Christophe

“…Polymeric micelles can substantially improve the oral bioavailability of class II drugs. In the case of chronic therapies, the oral route is often the…”
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In vitro and in vivo pharmacokinetic characterization, chiral conversion and PBPK scaling towards human PK simulation of S-MRI-1867, a drug candidate for Hermansky-Pudlak syndrome pulmonary fibrosis by Padilha, Elias C., Yang, Mengbi, Shah, Pranav, Wang, Amy Q., Duan, Jianmin, Park, Joshua K., Zawatsky, Charles N., Malicdan, May Christine V., Kunos, George, Iyer, Malliga R., Gaucher, Geneviève, Ravenelle, François, Cinar, Resat, Xu, Xin

“…Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder that affects lysosome-related organelles, often leading to fatal pulmonary fibrosis…”
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Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) by Gagné, Jean-François, Montminy, Valerie, Belanger, Patrick, Journault, Kim, Gaucher, Genevieve, Guillemette, Chantal

“…7-Ethyl-10-hydroxycamptothecin (SN-38) is the pharmacologically active metabolite of irinotecan, in addition to being responsible for severe toxicity…”
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Stereocomplex Block Copolymer Micelles:  Core−Shell Nanostructures with Enhanced Stability by Kang, Ning, Perron, Marie-Ève, Prud'homme, Robert E, Zhang, Yubao, Gaucher, Geneviève, Leroux, Jean-Christophe

“…Monodisperse stereocomplex block copolymer micelles were obtained through the self-assembly of equimolar mixtures of poly(ethylene…”
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Poly(N-vinyl-pyrrolidone)-block-poly(D,L-lactide) as polymeric emulsifier for the preparation of biodegradable nanoparticles by Gaucher, Geneviève, Poreba, Monika, Ravenelle, François, Leroux, Jean-Christophe

“…Poly(D,L-lactide) (PDLLA) amphiphilic block copolymers were employed as emulsifiers in the preparation of PDLLA nanoparticles by an oil/water emulsion solvent…”
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Delivery of Hydrophobic Drugs through Self-Assembling Nanostructures by Gaucher, G., Fournier, E., Le Garrec, D., Nabil Khalid, M., Hoarau, D., Sant, V., Leroux, J.

“…Many potent therapeutic agents possess a high degree of hydrophobicity which can greatly impede their solubilization in aqueous media and thus hamper their…”
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