Search Results - "Gates, Leah A."

Histone Marks in the ‘Driver’s Seat’: Functional Roles in Steering the Transcription Cycle by Gates, Leah A., Foulds, Charles E., O’Malley, Bert W.

“…Particular chromatin modifications are associated with different states of gene transcription, yet our understanding of which modifications are causal…”
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In situ chromatin interactomics using a chemical bait and trap approach by Burton, Antony J., Haugbro, Michael, Gates, Leah A., Bagert, John D., Allis, C. David, Muir, Tom W.

“…Elucidating the physiological binding partners of histone post-translational modifications (hPTMs) is key to understanding fundamental epigenetic regulatory…”
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Coactivator-Dependent Oscillation of Chromatin Accessibility Dictates Circadian Gene Amplitude via REV-ERB Loading by Zhu, Bokai, Gates, Leah A., Stashi, Erin, Dasgupta, Subhamoy, Gonzales, Naomi, Dean, Adam, Dacso, Clifford C., York, Brian, O’Malley, Bert W.

“…A central mechanism for controlling circadian gene amplitude remains elusive. We present evidence for a “facilitated repression (FR)” model that functions as…”
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Proteomic Analysis of Coregulators Bound to ERα on DNA and Nucleosomes Reveals Coregulator Dynamics by Foulds, Charles E., Feng, Qin, Ding, Chen, Bailey, Suzanna, Hunsaker, Tamra L., Malovannaya, Anna, Hamilton, Ross A., Gates, Leah A., Zhang, Zheng, Li, Chunshu, Chan, Doug, Bajaj, Amol, Callaway, Celetta G., Edwards, Dean P., Lonard, David M., Tsai, Sophia Y., Tsai, Ming-Jer, Qin, Jun, O’Malley, Bert W.

“…Chromatin immunoprecipitation studies have mapped protein occupancies at many genomic loci. However, a detailed picture of the complexity of coregulators…”
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Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation by Gates, Leah A., Shi, Jiejun, Rohira, Aarti D., Feng, Qin, Zhu, Bokai, Bedford, Mark T., Sagum, Cari A., Jung, Sung Yun, Qin, Jun, Tsai, Ming-Jer, Tsai, Sophia Y., Li, Wei, Foulds, Charles E., O'Malley, Bert W.

“…The transition from transcription initiation to elongation is a key regulatory step in gene expression, which requires RNA polymerase II (pol II) to escape…”
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ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase by Williams, Robert T., Guarecuco, Rohiverth, Gates, Leah A., Barrows, Douglas, Passarelli, Maria C., Carey, Bryce, Baudrier, Lou, Jeewajee, Swarna, La, Konnor, Prizer, Benjamin, Malik, Sohail, Garcia-Bermudez, Javier, Zhu, Xiphias Ge, Cantor, Jason, Molina, Henrik, Carroll, Thomas, Roeder, Robert G., Abdel-Wahab, Omar, Allis, C. David, Birsoy, Kıvanç

“…Activating transcription factor 4 (ATF4) is a master transcriptional regulator of the integrated stress response (ISR) that enables cell survival under…”
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Crosstalk between histone modifications indicates that inhibition of arginine methyltransferase CARM1 activity reverses HIV latency by Zhang, Zheng, Nikolai, Bryan C, Gates, Leah A, Jung, Sung Yun, Siwak, Edward B, He, Bin, Rice, Andrew P, O'Malley, Bert W, Feng, Qin

“…In eukaryotic cells, the gene expression status is strictly controlled by epigenetic modifications on chromatin. The repressive status of chromatin largely…”
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Stable isotope tracing in vivo reveals a metabolic bridge linking the microbiota to host histone acetylation by Lund, Peder J., Gates, Leah A., Leboeuf, Marylene, Smith, Sarah A., Chau, Lillian, Lopes, Mariana, Friedman, Elliot S., Saiman, Yedidya, Kim, Min Soo, Shoffler, Clarissa A., Petucci, Christopher, Allis, C. David, Wu, Gary D., Garcia, Benjamin A.

“…The gut microbiota influences acetylation on host histones by fermenting dietary fiber into butyrate. Although butyrate could promote histone acetylation by…”
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Proteomic profiling identifies key coactivators utilized by mutant ERα proteins as potential new therapeutic targets by Gates, Leah A., Gu, Guowei, Chen, Yue, Rohira, Aarti D., Lei, Jonathan T., Hamilton, Ross A., Yu, Yang, Lonard, David M., Wang, Jin, Wang, Shu-Ping, Edwards, David G., Lavere, Philip F., Shao, Jiangyong, Yi, Ping, Jain, Antrix, Jung, Sung Yun, Malovannaya, Anna, Li, Shunqiang, Shao, Jieya, Roeder, Robert G., Ellis, Matthew J., Qin, Jun, Fuqua, Suzanne A. W., O’Malley, Bert W., Foulds, Charles E.

“…Approximately 75% of breast cancers are estrogen receptor alpha (ERα)-positive and are treatable with endocrine therapies, but often patients develop lethal…”
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Trapping of cis-2-butene-1,4-dial to measure furan metabolism in human liver microsomes by cytochrome P450 enzymes by Gates, Leah A, Lu, Ding, Peterson, Lisa A

“…Furan is a liver toxicant and carcinogen in rodents. It is classified as a possible human carcinogen, but the human health effects of furan exposure remain…”
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Abundant Rodent Furan-Derived Urinary Metabolites Are Associated with Tobacco Smoke Exposure in Humans by Grill, Alex E, Schmitt, Thaddeus, Gates, Leah A, Lu, Ding, Bandyopadhyay, Dipankar, Yuan, Jian-Min, Murphy, Sharon E, Peterson, Lisa A

“…Furan, a possible human carcinogen, is found in heat treated foods and tobacco smoke. Previous studies have shown that humans are capable of converting furan…”
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Comparative metabolism of furan in rodent and human cryopreserved hepatocytes by Gates, Leah A, Phillips, Martin B, Matter, Brock A, Peterson, Lisa A

“…Furan is a liver toxicant and carcinogen in rodents. Although humans are most likely exposed to furan through a variety of sources, the effect of furan…”
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Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression by Gates, Leah A., Reis, Bernardo Sgarbi, Lund, Peder J., Paul, Matthew R., Leboeuf, Marylene, Djomo, Annaelle M., Nadeem, Zara, Lopes, Mariana, Vitorino, Francisca N., Unlu, Gokhan, Carroll, Thomas S., Birsoy, Kivanç, Garcia, Benjamin A., Mucida, Daniel, Allis, C. David

“…Post-translational modifications (PTMs) on histones are a key source of regulation on chromatin through impacting cellular processes, including gene expression…”
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Proteomic profiling identifies key coactivators utilized by mutant ER[alpha] proteins as potential new therapeutic targets by Gates, Leah A, Gu, Guowei, Chen, Yue, Rohira, Aa, Lei, Jonathan T, Hamilton, Ross A, Yu, Yang

“…Approximately 75% of breast cancers are estrogen receptor alpha (ER[alpha])-positive and are treatable with endocrine therapies, but often patients develop…”
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