Search Results - "Gates, Eric W.J."

Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity by Rorke, Ellen A., Adhikary, Gautam, Szmacinski, Henryk, Lakowicz, Joseph R., Weber, David J., Godoy‐Ruiz, Raquel, Puranik, Purushottamachar, Keillor, Jeffrey W., Gates, Eric W. J., Eckert, Richard L.

“…Type 2 transglutaminase (TG2) functions as an important cancer cell survival protein in a range of cancers including epidermal squamous cell carcinoma. TG2…”
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High-Affinity Fluorogenic Substrate for Tissue Transglutaminase Reveals Enzymatic Hysteresis by Gates, Eric W. J., Prince-Hallée, Adrien, Heidari, Yasaman, Sedighi, Abootaleb, Keillor, Jeffrey W.

“…Transglutaminases (TGases) are a family of calcium-dependent enzymes primarily known for their ability to cross-link proteins. Transglutaminase 2 (TG2) is one…”
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Transcriptomics Studies Reveal Functions of Transglutaminase 2 in Breast Cancer Cells Using Membrane Permeable and Impermeable Inhibitors by Ancona, Pietro, Trentini, Alessandro, Terrazzan, Anna, Grassilli, Silvia, Navals, Pauline, Gates, Eric W.J., Rosta, Valentina, Cervellati, Carlo, Bergamini, Carlo M., Pignatelli, Angela, Keillor, Jeffrey W., Taccioli, Cristian, Bianchi, Nicoletta

“…[Display omitted] •Transglutaminase 2 displays yet to be defined roles inside and outside the cell.•Membrane permeable and impermeable inhibitors are valid…”
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Structure-activity relationships of N-terminal variants of peptidomimetic tissue transglutaminase inhibitors by McNeil, Nicole M.R., Gates, Eric W.J., Firoozi, Neda, Cundy, Nicholas J., Leccese, Jessica, Eisinga, Sarah, Tyndall, Joel D.A., Adhikary, Gautam, Eckert, Richard L., Keillor, Jeffrey W.

“…Tissue transglutaminase (TG2) is a multifunctional protein that catalyses protein crosslinking in the extracellular matrix, and functions as an intracellular…”
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Peptidic Inhibitors and a Fluorescent Probe for the Selective Inhibition and Labelling of Factor XIIIa Transglutaminase by Gates, Eric W J, Mansour, Kian, Ebrahimi Samani, Sahar, Shad, Sammir, Kaartinen, Mari T, Keillor, Jeffrey W

“…Factor XIIIa (FXIIIa) is a transglutaminase of major therapeutic interest for the development of anticoagulants due to its essential role in the blood…”
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Cell-Impermeable Inhibitors Confirm That Intracellular Human Transglutaminase 2 Is Responsible for the Transglutaminase-Associated Cancer Phenotype by Gates, Eric W. J, Calvert, Nicholas D, Cundy, Nicholas J, Brugnoli, Federica, Navals, Pauline, Kirby, Alexia, Bianchi, Nicoletta, Adhikary, Gautam, Shuhendler, Adam J, Eckert, Richard L, Keillor, Jeffrey W

“…Transglutaminase 2 (TG2) is a multifunctional enzyme primarily responsible for crosslinking proteins. Ubiquitously expressed in humans, TG2 can act either as a…”
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A Multidisciplinary Approach Establishes a Link between Transglutaminase 2 and the Kv10.1 Voltage-Dependent K + Channel in Breast Cancer by Canella, Rita, Brugnoli, Federica, Gallo, Mariana, Keillor, Jeffrey W, Terrazzan, Anna, Ferrari, Elena, Grassilli, Silvia, Gates, Eric W J, Volinia, Stefano, Bertagnolo, Valeria, Bianchi, Nicoletta, Bergamini, Carlo M

“…Since the multifunctionality of transglutaminase 2 (TG2) includes extra- and intracellular functions, we investigated the effects of intracellular…”
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Novel irreversible peptidic inhibitors of transglutaminase 2 by Cundy, Nicholas J, Arciszewski, Jane, Gates, Eric W. J, Acton, Sydney L, Passley, Kyle D, Awoonor-Williams, Ernest, Boyd, Elizabeth K, Xu, Nancy, Pierson, Élise, Fernandez-Ansieta, Catalina, Albert, Marie R, McNeil, Nicole M. R, Adhikary, Gautam, Eckert, Richard L, Keillor, Jeffrey W

“…Transglutaminase 2 (TG2), also referred to as tissue transglutaminase, plays crucial roles in both protein crosslinking and cell signalling. It is capable of…”
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