Search Results - "Gately, Maurice K."

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses by Gately, Maurice K, Renzetti, Louis M, Magram, Jeanne, Stern, Alvin S, Adorini, Luciano, Gubler, Ueli, Presky, David H

“…Interleukin-12 (IL-12) is a heterodimeric cytokine that plays a central role in promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated…”
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A Functional Interleukin 12 Receptor Complex is Composed of Two β -type Cytokine Receptor Subunits by Presky, David H., Yang, Hong, Minetti, Lisa J., Chua, Anne O., Nabavi, Nasrin, Wu, Chang-You, Gately, Maurice K., Gubler, Ueli

“…We have identified a cDNA from a human phytohemagglutinin-activated lymphoblast library encoding a protein that binds125I-labeled human interleukin 12…”
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Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo by Lieschke, Graham J, Rao, Prakash K, Gately, Maurice K, Mulligan, Richard C

“…Interleukin-12 (IL-12) is unique amongst cytokines in being a disulfide-linked heterodimer of two separately encoded subunits (p35 and p40). We expressed…”
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IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses by Magram, Jeanne, Connaughton, Suzanne E, Warrier, Rajeev R, Carvajal, Daisy M, Wu, Chang-you, Ferrante, Jessica, Stewart, Colin, Sarmiento, Ulla, Faherty, Denise A, Gately, Maurice K

“…IL-12 is a cytokine that can exert regulatory effects on T and NK cells and promote Th1 responses. To delineate further the physiologic role of IL-12 in…”
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Interleukin-12 Is Essential for a Protective Th1 Response in Mice Infected with Cryptococcus neoformans by Decken, K, Köhler, G, Palmer-Lehmann, K, Wunderlin, A, Mattner, F, Magram, J, Gately, M K, Alber, G

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist by Gillessen, S, Carvajal, D, Ling, P, Podlaski, F J, Stremlo, D L, Familletti, P C, Gubler, U, Presky, D H, Stern, A S, Gately, M K

“…Interleukin-12 (IL-12) is a cytokine that has regulatory effects on T and natural killer (NK) cells and is composed of two disulfide-bonded subunits, p40 and…”
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Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo by Germann, T, Bongartz, M, Dlugonska, H, Hess, H, Schmitt, E, Kolbe, L, Kölsch, E, Podlaski, F J, Gately, M K, Rüde, E

“…The influence of the cytokine interleukin-12 (IL-12) on humoral immune responses was studied in vivo. CBA/J mice immunized with protein antigens (keyhole…”
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Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo by Gately, M K, Warrier, R R, Honasoge, S, Carvajal, D M, Faherty, D A, Connaughton, S E, Anderson, T D, Sarmiento, U, Hubbard, B R, Murphy, M

“…IL-12 is a heterodimeric cytokine that has been shown to enhance natural killer (NK) and cytotoxic T lymphocyte (CTL) responses, and to induce IFN-gamma…”
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Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice by McIntyre, K W, Shuster, D J, Gillooly, K M, Warrier, R R, Connaughton, S E, Hall, L B, Arp, L H, Gately, M K, Magram, J

“…Collagen-induced arthritis (CIA) is an animal model for rheumatoid arthritis. The disease is elicited by immunization of genetically susceptible DBA/1 mice…”
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Regulation of human cytolytic lymphocyte responses by interleukin-12 by Gately, M K, Wolitzky, A G, Quinn, P M, Chizzonite, R

“…IL-12 is a heterodimeric cytokine which has been shown to cause the proliferation of activated T and NK cells, to enhance the lytic activity of NK cells, and…”
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IL-12 is dispensable for innate and adaptive immunity against low doses of Listeria monocytogenes by Brombacher, Frank, Dorfmüller, Andreas, Magram, Jeanne, Dai, Wen Juan, Köhler, Gabriele, Wunderlin, Andrea, Palmer-Lehmann, Kathrin, Gately, Maurice K., Alber, Gottfried

“…We have studied IL-12p35-deficient (IL-12p35–/–) mice to evaluate the role of IL-12 in resistance against Listeria monocytogenes. In the absence of bioactive…”
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Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo by Gately, M K, Carvajal, D M, Connaughton, S E, Gillessen, S, Warrier, R R, Kolinsky, K D, Wilkinson, V L, Dwyer, C M, Higgins, Jr, G F, Podlaski, F J, Faherty, D A, Familletti, P C, Stern, A S, Presky, D H

“…Mo(p40)2 is a potent IL-12 antagonist that interacts strongly with the beta 1 subunit of the IL-12R to block binding of moIL-12 to the high-affinity mouse…”
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Analysis of the Multiple Interactions Between IL-12 and the High Affinity IL-12 Receptor Complex by Presky, David H, Minetti, Lisa J, Gillessen, Silke, Wilkinson, Victoria L, Wu, Chang-You, Gubler, Ueli, Chizzonite, Richard, Gately, Maurice K

“…IL-12 is a heterodimeric cytokine, composed of a p40 and a p35 subunit, that exerts its biological effects by binding to specific cell surface receptors. Two…”
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Lymphoid Cell-Glioma Cell Interaction Enhances Cell Coat Production by Human Gliomas: Novel Suppressor Mechanism by Dick, Steven J., Macchi, Beatrice, Papazoglou, Savvas, Oldfield, Edward H., Kornblith, Paul L., Smith, Barry H., Gately, Maurice K.

“…Certain human glioma lines produce mucopolysaccharide coats that impair the generation of cytolytic lymphocytes in response to these lines in vitro. Coat…”
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Measurement of human and mouse interleukin-12 by Gately, Maurice K, Chizzonite, Richard, Presky, David H

“…This unit describes functional assays for measurement of bioactive IL-12 and ELISAs for measurement of IL-12 protein. The functional assays are based on the…”
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Administration of recombinant interleukin-12 to mice suppresses hematopoiesis in the bone marrow but enhances hematopoiesis in the spleen by Tare, N S, Bowen, S, Warrier, R R, Carvajal, D M, Benjamin, W R, Riley, J H, Anderson, T D, Gately, M K

“…Although IL-12 has been reported to synergize with c-kit ligand (KL) in promoting hematopoietic stem cell proliferation in vitro, administration of recombinant…”
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Structure-Function Analysis of the p35 Subunit of Mouse Interleukin 12 (∗) by Zou, Jun J., Schoenhaut, David S., Carvajal, Daisy M., Warrier, Rajeev R., Presky, David H., Gately, Maurice K., Gubler, Ueli

“…Mouse IL-12 acts on both mouse and human cells; human IL-12 acts only on human cells. This species specificity is determined by the p35 subunit of the IL-12…”
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The role of IL-12 in the induction of organ-specific autoimmune diseases by Trembleau, Sylvie, Adorini, Luciano, Germann, Tieno, Gately, Maurice K.

“…The concept that T cells are subdivided into T helper 1 (Th1) and Th2 subsets was recently extended to suggest that Th1 cells contribute to the pathogenesis of…”
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Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response by Mattner, F, Magram, J, Ferrante, J, Launois, P, Di Padova, K, Behin, R, Gately, M K, Louis, J A, Alber, G

“…Mice with homologous disruption of the gene coding for either the p35 subunit or the p40 subunit of interleukin-12 (IL-12) and derived from a strain…”
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Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice by Trembleau, S, Penna, G, Bosi, E, Mortara, A, Gately, M K, Adorini, L

“…T cells play a major role in the development of insulin-dependent diabetes mellitus (IDDM) in nonobese diabetic (NOD) mice. Administration of interleukin 12…”
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