Search Results - "Gatehouse, D.G."

Evaluation of the potential genotoxicity of the phosphate binder lanthanum carbonate by Damment, S.J.P., Beevers, C., Gatehouse, D.G.

“…Lanthanum was evaluated for potential genotoxicity using a range of in vitro assays (as the carbonate) in the presence and absence of post-mitochondrial…”
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The single laser flow cytometric micronucleus test: a time course study using colchicine and urethane in rat and mouse peripheral blood and acetaldehyde in rat peripheral blood by Hynes, G.M., Torous, D.K., Tometsko, C.R., Burlinson, B., Gatehouse, D.G.

“…A single laser flow cytometric procedure to quantify micronucleus frequency in rat and mouse peripheral blood was evaluated. Reticulocytes express the…”
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The differential clastogenicity of Solvent Yellow 14 and FD & C Yellow No. 6 in vivo in the rodent micronucleus test (observations on species and tissue specificity) by Westmoreland, C, Gatehouse, D G

“…Solvent Yellow 14 is carcinogenic in rats, inducing neoplastic nodules of the liver, but is non-carcinogenic in mice. The present paper shows that Solvent…”
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Effects of aniline hydrochloride in the mouse bone marrow micronucleus test after oral administration by Westmoreland, C, Gatehouse, D G

“…Mice are non-responsive to aniline-induced carcinogenicity. However, the present paper shows that aniline hydrochloride induces micronuclei in the bone marrow…”
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Genotoxicity studies of gastric acid inhibiting drugs by Burlinson, B, Morriss, S H, Gatehouse, D G, Tweats, D J

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Alternatives to Aroclor 1254-induced S9 in in vitro genotoxicity assays by Elliott, B M, Combes, R D, Elcombe, C R, Gatehouse, D G, Gibson, G G, Mackay, J M, Wolf, R C

“…A working party was set up by the UK Environmental Mutagen Society to consider alternatives to Aroclor 1254 (Aroclor)-induced S9 in in vitro genotoxicity…”
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Investigations into the induction of aneuploidy and polyploidy in mammalian cells by the anti-tussive agent noscapine hydrochloride by Gatehouse, D G, Stemp, G, Pascoe, S, Wilcox, P, Hawker, J, Tweats, D J

“…Noscapine, a non-narcotic, centrally-acting anti-tussive drug induces polyploidy in Chinese hamster CHL cells; further studies were carried out to investigate…”
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A demonstration of the in vitro bacterial mutagenicity of procarbazine, using the microtitre fluctuation test and large concentrations of S9 fraction by Gatehouse, D G, Paes, D J

“…The anti-neoplastic agent procarbazine is genetically active in a variety of short term mutagenicity tests, and it also possesses carcinogenic and teratogenic…”
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Report of British Toxicology Society/UK Environmental Mutagen Society Working Group. Dose setting in in vivo mutagenicity assays by Fielder, R J, Allen, J A, Boobis, A R, Botham, P A, Doe, J, Esdaile, D J, Gatehouse, D G, Hodson-Walker, G, Morton, D B, Kirkland, D J

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