Search Results - "Gaston, J. S. H"

Cytokines in arthritis—the ‘big numbers’ move centre stage by Gaston, J. S. H.

“…More than 20 yrs ago, T-helper lymphocytes were divided into Th1 and Th2 subsets on the basis of their cytokine production. The pro-inflammatory Th1 subset was…”
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T-cell reactivity against HSP60 relates to early but not advanced atherosclerosis by Knoflach, M, Kiechl, S, Mayrl, B, Kind, M, Gaston, J.S.H, van der Zee, R, Faggionato, A, Mayr, A, Willeit, J, Wick, G

“…Abstract Background Anti-heat-shock protein 60 (HSP60) antibody-levels have been linked to carotid atherosclerosis and cardiovascular risk in a variety of…”
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Th17 cell responses in spondyloarthritis by Gaston, J.S.H., Jadon, D.R.

“…Targeting IL-17 has become an important option in the current treatment of spondyloarthritis (SpA). To place this therapeutic advancement in context, we review…”
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Comparison of two referral strategies for diagnosis of axial spondyloarthritis: the Recognising and Diagnosing Ankylosing Spondylitis Reliably (RADAR) study by Sieper, Joachim, Srinivasan, Shankar, Zamani, Omid, Mielants, Herman, Choquette, Denis, Pavelka, Karel, Loft, Anne Gitte, Géher, Pál, Danda, Debashish, Reitblat, Tatiana, Cantini, Fabrizio, Ancuta, Codrina, Erdes, Shandor, Raffayová, Helena, Keat, Andrew, Gaston, J S H, Praprotnik, Sonja, Vastesaeger, Nathan

“…To determine which of two referral strategies, when used by referring physicians for patients with chronic back pain (CBP), is superior for diagnosing axial…”
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Autoimmune T cell responses to seminal plasma in chronic pelvic pain syndrome (CPPS) by BATSTONE, G. R. D., DOBLE, A., GASTON, J. S. H.

“…SUMMARY The aetiology of chronic prostatitis is not understood. The aim of this study is to investigate an autoimmune hypothesis by looking for T cell…”
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Increased IL-4+ CD8+ T cells in peripheral blood and autoreactive CD8+ T cell lines of patients with inflammatory arthritis by Baek, H. J., Zhang, L., Jarvis, L. B., Gaston, J. S. H.

“…Objective. To measure the frequencies of IL-4+ CD8+ T cells from patients with AS and RA, and to assess their clinical relevance and properties. Methods…”
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Does HLA-B27 influence the monocyte inflammatory response to lipopolysaccharide? by Goodall, J. C., Ellis, L., Yeo, G. S. H., Gaston, J. S. H.

“…Objectives. How human leucocyte antigen B27 (HLA-B27) contributes towards arthritis susceptibility is still unclear, but effects on the response to bacteria…”
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Relationship of CD146 expression to secretion of interleukin (IL)‐17, IL‐22 and interferon‐γ by CD4+ T cells in patients with inflammatory arthritis by Wu, C., Goodall, J. C., Busch, R., Gaston, J. S. H.

“…Summary Expression of the adhesion molecule, CD146/MCAM/MelCAM, on T cells has been associated with recent activation, memory subsets and T helper type 17…”
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Effects of Chlamydia trachomatis infection on the expression of natural killer (NK) cell ligands and susceptibility to NK cell lysis by HOOK, C. E., TELYATNIKOVA, N., GOODALL, J. C., BRAUD, V. M., CARMICHAEL, A. J., WILLS, M. R., GASTON, J. S. H.

“…SUMMARY Natural killer (NK) cells are an important component of the immediate immune response to infections, including infection by intracellular bacteria. We…”
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T lymphocyte lines isolated from atheromatous plaque contain cells capable of responding to Chlamydia antigens by Curry, A. J., Portig, I., Goodall, J. C., Kirkpatrick, P. J., Gaston, J. S. H.

“…Chlamydia pneumoniae infection is associated with atherosclerosis and the organism has been identified in arterial lesions. To determine whether T…”
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Recognition of the 60 kilodalton cysteine‐rich outer membrane protein OMP2 by CD4+ T cells from humans infected with Chlamydia trachomatis by Goodall, J. C., Beacock‐Sharp, H., Deane, K. H. O., Gaston, J. S. H.

“…T cell‐mediated immunity is important in the control of chlamydia infection but chlamydia‐specific T cells are also implicated in the inflammation and tissue…”
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Immunological basis of chlamydia induced reactive arthritis by Gaston, J S H

“…An alternative view of the pathogenesis of the reactive arthritis is that it is the nature of the immune response to bacterial antigens which governs the…”
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Characterization of the humoral immune response to Chlamydia outer membrane protein 2 in chlamydial infection by Portig, I, Goodall, J C, Bailey, R L, Gaston, J S H

“…Detection of antibodies to an outer membrane protein 2 (OMP2) by enzyme-linked immunosorbent assay (ELISA) by using either the Chlamydia trachomatis- or the…”
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An open-label study of zoledronic acid (Aclasta 5 mg iv) in the treatment of ankylosing spondylitis by Clunie, G P R, Ginawi, A, O'Conner, P, Bearcroft, P W, Garber, S J, Bhagat, S, Grainger, A, Gaston, J S H

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Identification and characterization of a DR4‐restricted T cell epitope within chlamydia heat shock protein 60 by DEANE, K. H. O., JECOCK, R. M., PEARCE, J. H., GASTON, J. S. H.

“…An epitope within the 60 kD Chlamydia trachomatis heat shock protein (hsp) 60, recognized by a HLA‐DRB1*0401‐restricted T cell clone from a reactive arthritis…”
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Three month treatment of reactive arthritis with azithromycin: a EULAR double blind, placebo controlled study by Kvien, T K, Gaston, J S H, Bardin, T, Butrimiene, I, Dijkmans, B A C, Leirisalo-Repo, M, Solakov, P, Altwegg, M, Mowinckel, P, Plan, P-A, Vischer, T

“…Objective: To determine the efficacy of weekly treatment with oral azithromycin for 13 weeks on the severity and resolution of reactive arthritis (ReA)…”
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Identification and removal of a promiscuous CD4+ T cell epitope from the C1 domain of factor VIII by JONES, T. D., PHILLIPS, W. J., SMITH, B. J., BAMFORD, C. A., NAYEE, P. D., BAGLIN, T. P., GASTON, J. S. H., BAKER, M. P.

“…Summary  Background: The development of inhibitors in hemophiliacs is a severe complication of factor VIII (FVIII) replacement therapy and is a process driven…”
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Depressed proliferative responses by peripheral blood mononuclear cells from early arthritis patients to mycobacterial heat shock protein 60 by RAMAGE, J. M, GASTON, J. S. H

“…T-cell responses to mycobacterial heat shock protein 60 (M.hsp60) have been implicated in the pathogenesis of adjuvant arthritis, but whether they play a role…”
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Stimulation of peripheral blood lymphocytes with Campylobacter jejuni generates a γδ T cell response in patients with Guillain–Barré syndrome by BEN‐SMITH, A., GOODALL, J. C., GASTON, J. S. H., WINER, J. B.

“…In three patients whose Guillain–Barré syndrome (GBS) was preceded by gastrointestinal infection due to Campylobacter jejuni, γδ T cells were generated from…”
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Heat shock proteins and innate immunity by Gaston, J. S. H.

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