Search Results - "Gaston, David C"

Clinical Metagenomics for Infectious Diseases: Progress toward Operational Value by Gaston, David C

“…The field of clinical metagenomics for infectious disease diagnostics has advanced to combining questions of technical methodologies with best-use practices…”
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The displacement of the SARS-CoV-2 variant Delta with Omicron: An investigation of hospital admissions and upper respiratory viral loads by Fall, Amary, Eldesouki, Raghda E., Sachithanandham, Jaiprasath, Morris, C. Paul, Norton, Julie M., Gaston, David C., Forman, Michael, Abdullah, Omar, Gallagher, Nicholas, Li, Maggie, Swanson, Nicholas J., Pekosz, Andrew, Klein, Eili Y., Mostafa, Heba H.

“…The increase in SARS-CoV-2 infections in December 2021 was driven primarily by the Omicron variant, which largely displaced the Delta over a three-week span…”
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Large Scale SARS-CoV-2 Molecular Testing and Genomic Surveillance Reveal Prolonged Infections, Protracted RNA shedding, and Viral Reinfections by Morris, C Paul, Luo, Chun Huai, Sachithanandham, Jaiprasath, Li, Maggie, Schwartz, Matthew, Gaston, David C, Gniazdowski, Victoria, Giraldo-Castillo, Nicolas, Amadi, Adannaya, Norton, Julie M, Wright, William F, Klein, Eili Y, Pekosz, Andrew, Mostafa, Heba H

“…Large-scale SARS-CoV-2 molecular testing coupled with whole genome sequencing in the diagnostic laboratories is instrumental for real-time genomic…”
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Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1 by Gaston, David C, Odom, Carl I, Li, Li, Markert, James M, Roth, Justin C, Cassady, Kevin A, Whitley, Richard J, Parker, Jacqueline N

“…Oncolytic type-1 herpes simplex viruses (oHSVs) lacking the γ134.5 neurovirulence gene are being evaluated for treatment of a variety of malignancies. oHSVs…”
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SARS-CoV-2 reinfections during the Delta and Omicron waves by Morris, C Paul, Eldesouki, Raghda E, Fall, Amary, Gaston, David C, Norton, Julie M, Gallagher, Nicholas D, Luo, Chun Huai, Abdullah, Omar, Klein, Eili Y, Mostafa, Heba H

“…BACKGROUNDIncreased SARS-CoV-2 reinfection rates have been reported recently, with some locations basing reinfection on a second positive PCR test at least 90…”
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Increasing Parechovirus Central Nervous System Infections and the Enduring Value of Clinical Microbiology Laboratories by Tao, Lili, Gaston, David C

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Tocilizumab Treatment for Cytokine Release Syndrome in Hospitalized Patients With Coronavirus Disease 2019: Survival and Clinical Outcomes by Price, Christina C, Altice, Frederick L, Shyr, Yu, Koff, Alan, Pischel, Lauren, Goshua, George, Azar, Marwan M, Mcmanus, Dayna, Chen, Sheau-Chiann, Gleeson, Shana E, Britto, Clemente J, Azmy, Veronica, Kaman, Kelsey, Gaston, David C, Davis, Matthew, Burrello, Trisha, Harris, Zachary, Villanueva, Merceditas S, Aoun-Barakat, Lydia, Kang, Insoo, Seropian, Stuart, Chupp, Geoffrey, Bucala, Richard, Kaminski, Naftali, Lee, Alfred I, LoRusso, Patricia Mucci, Topal, Jeffrey E, Dela Cruz, Charles, Malinis, Maricar

“…Tocilizumab, an IL-6 receptor antagonist, can be used to treat cytokine release syndrome (CRS), with observed improvements in a coronavirus disease 2019…”
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Taking the Next Step in Metagenomic Infectious Disease Diagnostics by Gaston, David C, Simner, Patricia J

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Infection With the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant Is Associated With Higher Recovery of Infectious Virus Compared to the Alpha Variant in Both Unvaccinated and Vaccinated Individuals by Huai Luo, Chun, Paul Morris, C, Sachithanandham, Jaiprasath, Amadi, Adannaya, Gaston, David C, Li, Maggie, Swanson, Nicholas J, Schwartz, Matthew, Klein, Eili Y, Pekosz, Andrew, Mostafa, Heba H

“…Abstract Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) B.1.617.2 (Delta) displaced B.1.1.7 (Alpha) and…”
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Evaluation of Metagenomic and Targeted Next-Generation Sequencing Workflows for Detection of Respiratory Pathogens from Bronchoalveolar Lavage Fluid Specimens by Gaston, David C, Miller, Heather B, Fissel, John A, Jacobs, Emily, Gough, Ethan, Wu, Jiajun, Klein, Eili Y, Carroll, Karen C, Simner, Patricia J

“…Next-generation sequencing (NGS) workflows applied to bronchoalveolar lavage (BAL) fluid specimens could enhance the detection of respiratory pathogens,…”
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Metagenomics in infectious disease diagnostics: Toward best‐use practices to optimize actionable results by Parrish, Nicholas F., Gaston, David C.

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Rapid implementation of blood culture stewardship: institutional response to an acute national blood culture bottle shortage by Humphries, Romney M, Wright, Patty W, Banerjee, Ritu, Dulek, Daniel E, Champion, John C, Gaston, David C, Talbot, Thomas R

“…We describe our approach to addressing a nation-wide supply issue for blood culture bottles. Aerobic blood culture bottles received from our distributor July…”
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Clinical implications of SARS‐CoV‐2 cycle threshold values in solid organ transplant recipients by Gaston, David C., Malinis, Maricar, Osborn, Rebecca, Peaper, David R., Landry, Marie, Juthani‐Mehta, Manisha, Azar, Marwan M.

“…Detection of SARS‐CoV‐2 viral RNA by RT‐PCR assays is the primary diagnostic test for COVID‐19. Cycle threshold (CT) values generated by some of these assays…”
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The Brief Case: The Fly Who Cried Wohlf by Ahmad, Yembur, Gaston, David C, Gray, Josh, Zhong, Diana, Gudenkauf, Brent, Bourdas, Dimitrios, Ray, Stuart C, Simner, Patricia J

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Closing the Brief Case: The Fly Who Cried Wohlf by Ahmad, Yembur, Gaston, David C, Gray, Josh, Zhong, Diana, Gudenkauf, Brent, Bourdas, Dimitrios, Ray, Stuart C, Simner, Patricia J

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Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Variants on Inpatient Clinical Outcome by Robinson, Matthew L, Morris, C Paul, Betz, Joshua F, Zhang, Yifan, Bollinger, Robert, Wang, Natalie, Thiemann, David R, Fall, Amary, Eldesouki, Raghda E, Norton, Julie M, Gaston, David C, Forman, Michael, Luo, Chun Huai, Zeger, Scott L, Gupta, Amita, Garibaldi, Brian T, Mostafa, Heba H

“…Abstract Background Prior observation has shown differences in COVID-19 hospitalization risk between SARS-CoV-2 variants, but limited information describes…”
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Emerging Microbiology Diagnostics for Transplant Infections: On the Cusp of a Paradigm Shift by Azar, Marwan M., Gaston, David C., Kotton, Camille N., Malinis, Maricar F.

“…In light of the heightened risk for infection associated with solid organ and hematopoietic stem cell transplantation, rapid and accurate microbiology…”
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Diagnostic Stewardship for Next-Generation Sequencing Assays in Clinical Microbiology: An Appeal for Thoughtful Collaboration by Gaston, David C, Chiang, Augusto Dulanto, Dee, Kevin, Dulek, Daniel, Banerjee, Ritu, Humphries, Romney M

“…Next-generation sequencing (NGS)-based assays are primarily available from reference laboratories for diagnostic use. These tests can provide helpful…”
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Re-emergence of Parechovirus: 2017–2022 National Trends of Detection in Cerebrospinal Fluid by Tao, Lili, Humphries, Romney M, Banerjee, Ritu, Gaston, David C

“…Abstract Increasing parechovirus (PeV) infections prompted a Centers for Disease Control and Prevention Health Advisory in July 2022. We retrospectively…”
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Fever, Rash, and Migratory Polyarthralgias by Gaston, David C, Peaper, David R, Advani, Sonali D

“…A 24-year-old farmworker had 3 weeks of persistent fever and worsening polyarthralgias, and maculopapular truncal rash that spread to her palms and soles…”
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