Search Results - "Gast, Alain"

Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7 by Jaeger, Kathrin, Bruenle, Steffen, Weinert, Tobias, Guba, Wolfgang, Muehle, Jonas, Miyazaki, Takuya, Weber, Martin, Furrer, Antonia, Haenggi, Noemi, Tetaz, Tim, Huang, Chia-Ying, Mattle, Daniel, Vonach, Jean-Marie, Gast, Alain, Kuglstatter, Andreas, Rudolph, Markus G., Nogly, Przemyslaw, Benz, Joerg, Dawson, Roger J.P., Standfuss, Joerg

“…The CC chemokine receptor 7 (CCR7) balances immunity and tolerance by homeostatic trafficking of immune cells. In cancer, CCR7-mediated trafficking leads to…”
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Design and Synthesis of Potent and Highly Selective Thrombin Inhibitors by Hilpert, Kurt, Ackermann, Jean, Banner, David W., Gast, Alain, Gubernator, Klaus, Hadvary, Paul, Labler, Ludvik, Mueller, Klaus, Schmid, Gerard

“…Thrombin, a serine protease, plays a central role in the initiation and propagation of thrombotic events. An extensive search for new thrombin inhibitors was…”
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Stable Expression and Purification of a Secreted Human Recombinant Prethrombin-2 and Its Activation to Thrombin by Russo, Giulia, Gast, Alain, Schlaeger, Ernst-Jürgen, Angiolillo, Antonietta, Pietropaolo, Concetta

“…A human prothrombin cDNA has been engineered to obtain a cDNA coding for a secreted form of human prethrombin-2. The secreted prethrombin-2 has been produced…”
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Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones by Banner, David W., Gsell, Bernard, Benz, Jörg, Bertschinger, Julian, Burger, Dominique, Brack, Simon, Cuppuleri, Simon, Debulpaep, Maja, Gast, Alain, Grabulovski, Dragan, Hennig, Michael, Hilpert, Hans, Huber, Walter, Kuglstatter, Andreas, Kusznir, Eric, Laeremans, Toon, Matile, Hugues, Miscenic, Christian, Rufer, Arne C., Schlatter, Daniel, Steyaert, Jan, Stihle, Martine, Thoma, Ralf, Weber, Martin, Ruf, Armin

“…The aspartic protease BACE2 is responsible for the shedding of the transmembrane protein Tmem27 from the surface of pancreatic β‐cells, which leads to…”
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Synthesis and biological evaluation of 3-aryltyramines as fragments binding to BACE-1 and BACE-2 by Fehler, Stefanie K., Pratsch, Gerald, Huber, Walter, Gast, Alain, Hochstrasser, Remo, Hennig, Michael, Heinrich, Markus R.

“…3-Aryltyramines were prepared in one single step from tyramine and various arenediazonium salts by radical arylation. Binding as well as enzyme inhibition data…”
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Thrombin mutants with altered enzymatic activity have an impaired mitogenic effect on mouse fibroblasts and are inefficient modulators of stellation of rat cortical astrocytes by Arcone, Rosaria, Pagliuca, M.Gabriella, Chinali, Alberto, Grimaldi, Maurizio, Schettini, Gennaro, Gast, Alain, Pietropaolo, Concetta

“…We produced recombinant human thrombin mutants to investigate the correlation between the thrombin enzyme and mitogenic activity. Single amino acid…”
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Activated clotting time as a appropriate test to compare heparin and direct thrombin inhibitors such as hirudin or Ro 46-6240 in experimental arterial thrombosis by CARTEAUX, J. P, GAST, A, TSCHOPP, T. B, ROUX, S

“…Specific thrombin inhibitors are considered to be more potent antithrombotics than heparin. However, the relation between the systemic anticoagulation…”
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Activated clotting time as an appropriate test to compare heparin and direct thrombin inhibitor such as hirudin or Ro 46-6240 in experimental arterial thrombosis by Carteaux, Jean Pierre, Gast, Alain, Tschopp, Thomas B, Roux, Sebastien

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The Development of Potent and Highly Selective Thrombin Inhibitors by Hilpert, Kurt, Ackermann, Jean, Banner, David W., Gast, Alain, Gubernator, Klaus, Schmid, Gérard, Tschopp, Thomas B., van de Waterbeemd, Han

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Inhibition of human neutrophil elastase by acid-soluble inter-alpha-trypsin inhibitor by Gast, A, Bieth, J G

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The elastase inhibitory capacity and the alpha 1-proteinase inhibitor and bronchial inhibitor content of bronchoalveolar lavage fluids from healthy subjects by Boudier, C, Pelletier, A, Gast, A, Tournier, J M, Pauli, G, Bieth, J G

“…Pulmonary emphysema is currently thought to be due to an elastase-antielastase imbalance with resultant destruction of alveolar structures. The present study…”
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The antielastase screen of the lower respiratory tract of alpha 1-proteinase inhibitor-sufficient patients with emphysema or pneumothorax by Gast, A, Dietemann-Molard, A, Pelletier, A, Pauli, G, Bieth, J G

“…The present study was aimed at testing whether alpha 1-proteinase inhibitor-sufficient patients with lung emphysema or idiopathic spontaneous pneumothorax have…”
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Pharmacokinetics and distribution of recombinant secretory leukocyte proteinase inhibitor in rats by Gast, A, Anderson, W, Probst, A, Nick, H, Thompson, R C, Eisenberg, S P, Schnebli, H

“…Secretory leukocyte proteinase inhibitor (SLPI) is a potent elastase, trypsin, and chymotrypsin inhibitor occurring in all mucous secretions. Its inhibitory…”
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