Search Results - "Gasser, Emanuel"

FGF1 — a new weapon to control type 2 diabetes mellitus by Gasser, Emanuel, Moutos, Christopher P., Downes, Michael, Evans, Ronald M.

“…Key Points Peripherally or centrally injected fibroblast growth factor 1 (FGF1) confers potent metabolic benefits in type 2 diabetes mellitus (T2DM) FGF1…”
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Glucagon-Induced Acetylation of Foxa2 Regulates Hepatic Lipid Metabolism by von Meyenn, Ferdinand, Porstmann, Thomas, Gasser, Emanuel, Selevsek, Nathalie, Schmidt, Alexander, Aebersold, Ruedi, Stoffel, Markus

“…Circulating levels of insulin and glucagon reflect the nutritional state of animals and elicit regulatory responses in the liver that maintain glucose and…”
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FXR Regulates Intestinal Cancer Stem Cell Proliferation by Fu, Ting, Coulter, Sally, Yoshihara, Eiji, Oh, Tae Gyu, Fang, Sungsoon, Cayabyab, Fritz, Zhu, Qiyun, Zhang, Tong, Leblanc, Mathias, Liu, Sihao, He, Mingxiao, Waizenegger, Wanda, Gasser, Emanuel, Schnabl, Bernd, Atkins, Annette R., Yu, Ruth T., Knight, Rob, Liddle, Christopher, Downes, Michael, Evans, Ronald M.

“…Increased levels of intestinal bile acids (BAs) are a risk factor for colorectal cancer (CRC). Here, we show that the convergence of dietary factors (high-fat…”
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Immune-evasive human islet-like organoids ameliorate diabetes by Yoshihara, Eiji, O’Connor, Carolyn, Gasser, Emanuel, Wei, Zong, Oh, Tae Gyu, Tseng, Tiffany W., Wang, Dan, Cayabyab, Fritz, Dai, Yang, Yu, Ruth T., Liddle, Christopher, Atkins, Annette R., Downes, Michael, Evans, Ronald M.

“…Islets derived from stem cells hold promise as a therapy for insulin-dependent diabetes, but there remain challenges towards achieving this goal 1 – 6 . Here…”
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Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility by Ahmed, Kashan, LaPierre, Mary P, Gasser, Emanuel, Denzler, Rémy, Yang, Yinjie, Rülicke, Thomas, Kero, Jukka, Latreille, Mathieu, Stoffel, Markus

“…MicroRNAs (miRNAs) are negative modulators of gene expression that fine-tune numerous biological processes. miRNA loss-of-function rarely results in highly…”
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FGF1 and insulin control lipolysis by convergent pathways by Sancar, Gencer, Liu, Sihao, Gasser, Emanuel, Alvarez, Jacqueline G., Moutos, Christopher, Kim, Kyeongkyu, van Zutphen, Tim, Wang, Yuhao, Huddy, Timothy F., Ross, Brittany, Dai, Yang, Zepeda, David, Collins, Brett, Tilley, Emma, Kolar, Matthew J., Yu, Ruth T., Atkins, Annette R., van Dijk, Theo H., Saghatelian, Alan, Jonker, Johan W., Downes, Michael, Evans, Ronald M.

“…Inexorable increases in insulin resistance, lipolysis, and hepatic glucose production (HGP) are hallmarks of type 2 diabetes. Previously, we showed that…”
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Adipose tissue retains an epigenetic memory of obesity after weight loss by Hinte, Laura C., Castellano-Castillo, Daniel, Ghosh, Adhideb, Melrose, Kate, Gasser, Emanuel, Noé, Falko, Massier, Lucas, Dong, Hua, Sun, Wenfei, Hoffmann, Anne, Wolfrum, Christian, Rydén, Mikael, Mejhert, Niklas, Blüher, Matthias, von Meyenn, Ferdinand

“…Abstract Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity 1,2 . However, maintaining weight…”
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Metabolic Messengers: fibroblast growth factor 1 by Gasser, Emanuel, Sancar, Gencer, Downes, Michael, Evans, Ronald M.

“…While fibroblast growth factor (FGF) 1 is expressed in multiple tissues, only adipose-derived and brain FGF1 have been implicated in the regulation of…”
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Foxa1 is essential for development and functional integrity of the subthalamic nucleus by Gasser, Emanuel, Johannssen, Helge C., Rülicke, Thomas, Zeilhofer, Hanns Ulrich, Stoffel, Markus

“…Inactivation of transcription factor Foxa1 in mice results in neonatal mortality of unknown cause. Here, we report that ablation of Foxa1 causes impaired…”
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Publisher Correction: Immune-evasive human islet-like organoids ameliorate diabetes by Yoshihara, Eiji, O’Connor, Carolyn, Gasser, Emanuel, Wei, Zong, Oh, Tae Gyu, Tseng, Tiffany W., Wang, Dan, Cayabyab, Fritz, Dai, Yang, Yu, Ruth T., Liddle, Christopher, Atkins, Annette R., Downes, Michael, Evans, Ronald M.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-03109-3…”
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Loss of microRNA-7a2 induces hypogonadotropic hypogonadism and infertility by Ahmed, Kashan, LaPierre, Mary P, Gasser, Emanuel, Denzler, Remy, Yang, Yinjie, Rulicke, Thomas, Kero, Jukka, Latreille, Mathieu, Stoffel, Markus

“…MicroRNAs (miRNAs) are negative modulators of gene expression that fine-tune numerous biological processes. miRNA loss-of-function rarely results in highly…”
Get full text