Comparison of oral and subcutaneous administration of buprenorphine and meloxicam for preemptive analgesia in cats undergoing ovariohysterectomy

To compare the effectiveness of preoperative PO and SC administration of buprenorphine and meloxicam for prevention of postoperative pain-associated behaviors in cats undergoing ovariohysterectomy. Randomized controlled study. 51 female cats (4 to 60 months old; weight range, 1.41 to 4.73 kg [3.1 to...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of the American Veterinary Medical Association Vol. 227; no. 12; pp. 1937 - 1944
Main Authors:	Gassel, A.D, Tobias, K.M, Egger, C.M, Rohrbach, B.W
Format:	Journal Article
Language:	English
Published:	United States 15-12-2005
Subjects:	Administration, Oral analgesia analgesics Analgesics, Non-Narcotic - administration & dosage Analgesics, Opioid - administration & dosage animal behavior Animals Behavior, Animal - drug effects buprenorphine Buprenorphine - administration & dosage cats Cats - physiology Cats - surgery Drug Administration Routes - veterinary Female females hysterectomy Hysterotomy - methods Hysterotomy - veterinary Injections, Subcutaneous - veterinary meloxicam oral administration ovariectomy Ovariectomy - methods Ovariectomy - veterinary pain Pain - prevention & control Pain - veterinary Postoperative Care - veterinary subcutaneous injection Thiazines - administration & dosage Thiazoles - administration & dosage Time Factors Treatment Outcome
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	To compare the effectiveness of preoperative PO and SC administration of buprenorphine and meloxicam for prevention of postoperative pain-associated behaviors in cats undergoing ovariohysterectomy. Randomized controlled study. 51 female cats (4 to 60 months old; weight range, 1.41 to 4.73 kg [3.1 to 10.4 lb]). Cats received 1 of 5 treatments at the time of anesthetic induction: buprenorphine PO (0.01 mg/kg [0.0045 mg/lb]; n = 10), buprenorphine SC (0.01 mg/kg; 10), meloxicam SC (0.3 mg/kg 10.14 mg/lb]; 10), meloxicam PO (0.3 mg/kg; 10), or 0.3 mL of sterile saline (0.9% NaCI) solution SC (control group; 11). Sedation scores and visual analog scale and interactive visual analog scale (IVAS) pain-associated behavior scores were assigned to each cat 2 hours before and at intervals until 20 hours after surgery. Cats receiving meloxicam PO or SC had significantly lower IVAS scores (2.91 and 2.02, respectively), compared with IVAS scores for cats receiving buprenorphine PO (755). Pain-associated behavior scores for cats administered buprenorphine or meloxicam PO or SC preoperatively did not differ significantly from control group scores. Rescue analgesia was not required by any of the cats receiving meloxicam, whereas 3 of 10 cats receiving buprenorphine PO, 2 of 10 cats receiving buprenorphine SC, and 1 of 11 cats receiving the control treatment required rescue analgesia. On the basis of pain-associated behavior scores, cats receiving meloxicam PO or SC before ovariohysterectomy appeared to have less pain after surgery than those receiving buprenorphine PO preoperatively.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0003-1488 1943-569X
DOI:	10.2460/javma.2005.227.1937