Search Results - "Gass, Jennifer N"

Activation of an Unfolded Protein Response during Differentiation of Antibody-secreting B Cells by Gass, Jennifer N, Gifford, Nicole M, Brewer, Joseph W

“…The u nfolded p rotein r esponse pathway (UPR) is believed to detect and compensate for excessive protein accumulation in the endoplasmic reticulum (ER). The…”
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The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells by Gass, Jennifer N., Jiang, Hao-Yuan, Wek, Ronald C., Brewer, Joseph W.

“…When B-lymphocytes differentiate into plasma cells, immunoglobulin (Ig) heavy and light chain synthesis escalates and the entire secretory apparatus expands to…”
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Stressed-out B cells? Plasma-cell differentiation and the unfolded protein response by Gass, Jennifer N., Gunn, Kathryn E., Sriburi, Rungtawan, Brewer, Joseph W.

“…Plasma cells operate as factories where large quantities of Ig heavy and light chains are made and assembled into functional antibodies. The finished products…”
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