Search Results - "Gasperini, Robert J."

STIM1 Is Required for Remodeling of the Endoplasmic Reticulum and Microtubule Cytoskeleton in Steering Growth Cones by Pavez, Macarena, Thompson, Adrian C, Arnott, Hayden J, Mitchell, Camilla B, D'Atri, Ilaria, Don, Emily K, Chilton, John K, Scott, Ethan K, Lin, John Y, Young, Kaylene M, Gasperini, Robert J, Foa, Lisa

“…The spatial and temporal regulation of calcium signaling in neuronal growth cones is essential for axon guidance. In growth cones, the endoplasmic reticulum…”
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Plasticity of Recurrent L2/3 Inhibition and Gamma Oscillations by Whisker Experience by Shao, Yu R., Isett, Brian R., Miyashita, Toshio, Chung, Jason, Pourzia, Olivia, Gasperini, Robert J., Feldman, Daniel E.

“…Local recurrent networks in neocortex are critical nodes for sensory processing, but their regulation by experience is much less understood than for…”
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STIM1 is necessary for store-operated calcium entry in turning growth cones by Mitchell, Camilla B., Gasperini, Robert J., Small, David H., Foa, Lisa

“…J. Neurochem. (2012) 122, 1155–1166. Coordinated calcium signalling is vital for neuronal growth cone function and axon pathfinding. Although store‐operated…”
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Serotonin functions as a bidirectional guidance molecule regulating growth cone motility by Vicenzi, Silvia, Foa, Lisa, Gasperini, Robert J.

“…The neurotransmitter serotonin has been implicated in a range of complex neurological disorders linked to alterations of neuronal circuitry. Serotonin is…”
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Comparison of baseline cataract rates in AB and TL wildtype zebrafish strains by Khatiwada, Bibek, Jones, Johanna L., Zhao, Duran, Gasperini, Robert J., McComish, Bennet J., Burdon, Kathryn P.

“…Zebrafish are an outstanding model for assessing the involvement of genes in paediatric cataracts. Gene discovery for cataracts is enhanced by manipulation of…”
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TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons by Gasperini, Robert J, Hou, Xu, Parkington, Helena, Coleman, Harry, Klaver, David W, Vincent, Adele J, Foa, Lisa C, Small, David H

“…Familial amyloidotic polyneuropathy (FAP) is a peripheral neuropathy caused by the extracellular accumulation and deposition of insoluble transthyretin (TTR)…”
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How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding? by Gasperini, Robert J., Pavez, Macarena, Thompson, Adrian C., Mitchell, Camilla B., Hardy, Holly, Young, Kaylene M., Chilton, John K., Foa, Lisa

“…The precision with which neurons form connections is crucial for the normal development and function of the nervous system. The development of neuronal…”
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Mechanisms of transthyretin aggregation and toxicity by Gasperini, Robert J, Klaver, David W, Hou, Xu, Aguilar, Marie-Isabel, Small, David H

“…Amyloidoses are characterised by the deposition of insoluble protein that occurs in the extracellular compartment of various tissues. One form of amyloidosis…”
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Rapid and efficient cataract gene evaluation in F0 zebrafish using CRISPR-Cas9 ribonucleoprotein complexes by Zhao, Duran, Jones, Johanna L., Gasperini, Robert J., Charlesworth, Jac C., Liu, Guei-Sheung, Burdon, Kathryn P.

“…•Direct and efficient methods to evaluate cataract candidate genes in F0 zebrafish.•Comprehensive guide RNA design instructions.•Strategies to saturate the…”
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Brain pericytes in culture display diverse morphological and functional phenotypes by Brown, Lachlan S., King, Natalie E., Courtney, Jo-Maree, Gasperini, Robert J., Foa, Lisa, Howells, David W., Sutherland, Brad A.

“…Pericytes play several important functions in the neurovascular unit including contractile control of capillaries, maintenance of the BBB, regulation of…”
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A New Method for Targeted and Sustained Induction of Type 2 Diabetes in Rodents by Premilovac, Dino, Gasperini, Robert J., Sawyer, Sarah, West, Adrian, Keske, Michelle A., Taylor, Bruce V., Foa, Lisa

“…Type 2 diabetes is a chronic metabolic disorder that is becoming a leading cause of morbidity and mortality. The prolonged time-course of human type 2 diabetes…”
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A 127 kb truncating deletion of PGRMC1 is a novel cause of X-linked isolated paediatric cataract by Jones, Johanna L, Corbett, Mark A, Yeaman, Elise, Zhao, Duran, Gecz, Jozef, Gasperini, Robert J, Charlesworth, Jac C, Mackey, David A, Elder, James E, Craig, Jamie E, Burdon, Kathryn P

“…Inherited paediatric cataract is a rare Mendelian disease that results in visual impairment or blindness due to a clouding of the eye's crystalline lens. Here…”
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The microtubule-stabilizing drug Epothilone D increases axonal sprouting following transection injury in vitro by Brizuela, Mariana, Blizzard, Catherine A., Chuckowree, Jyoti A., Dawkins, Edgar, Gasperini, Robert J., Young, Kaylene M., Dickson, Tracey C.

“…Neuronal cytoskeletal alterations, in particular the loss and misalignment of microtubules, are considered a hallmark feature of the degeneration that occurs…”
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Neurodegeneration in familal amyloidotic polyneuropathy by Gasperini, Robert J, Small, David H

“…Summary 1. Familial amyloid polyneuropathies (FAP) constitute a group of inherited amyloidoses that affect peripheral nerves. One common form of FAP is caused…”
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Neurodegeneration in familial amyloidotic polyneuropathy by Gasperini, Robert J, Small, David H

“…Familial amyloid polyneuropathies (FAP) constitute a group of inherited amyloidoses that affect peripheral nerves. One common form of FAP is caused by…”
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TRPM8 and Na.sub.v 1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons by Gasperini, Robert J, Hou, Xu, Parkington, Helena, Coleman, Harry, Klaver, David W, Vincent, Adele J, Foa, Lisa C, Small, David H

“…Background Familial amyloidotic polyneuropathy (FAP) is a peripheral neuropathy caused by the extracellular accumulation and deposition of insoluble…”
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TRPM8 and Nav 1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons by Gasperini, Robert J, Hou, Xu, Parkington, Helena, Coleman, Harry, Klaver, David W, Vincent, Adele J, Foa, Lisa C, Small, David H

“…Abstract Background: Familial amyloidotic polyneuropathy (FAP) is a peripheral neuropathy caused by the extracellular accumulation and deposition of insoluble…”
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