Search Results - "Gasparre, Giuseppe"

Non-Canonical Mechanisms Regulating Hypoxia-Inducible Factor 1 Alpha in Cancer by Iommarini, Luisa, Porcelli, Anna Maria, Gasparre, Giuseppe, Kurelac, Ivana

“…Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy…”
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HmtVar: a new resource for human mitochondrial variations and pathogenicity data by Preste, Roberto, Vitale, Ornella, Clima, Rosanna, Gasparre, Giuseppe, Attimonelli, Marcella

“…Abstract Interest in human mitochondrial genetic data is constantly increasing among both clinicians and researchers, due to the involvement of mitochondrial…”
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Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer by Sansone, Pasquale, Savini, Claudia, Kurelac, Ivana, Chang, Qing, Amato, Laura Benedetta, Strillacci, Antonio, Stepanova, Anna, Iommarini, Luisa, Mastroleo, Chiara, Daly, Laura, Galkin, Alexander, Thakur, Basant Kumar, Soplop, Nadine, Uryu, Kunihiro, Hoshino, Ayuko, Norton, Larry, Bonafé, Massimiliano, Cricca, Monica, Gasparre, Giuseppe, Lyden, David, Bromberg, Jacqueline

“…The horizontal transfer of mtDNA and its role in mediating resistance to therapy and an exit from dormancy have never been investigated. Here we identified the…”
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MToolBox: a highly automated pipeline for heteroplasmy annotation and prioritization analysis of human mitochondrial variants in high-throughput sequencing by Calabrese, Claudia, Simone, Domenico, Diroma, Maria Angela, Santorsola, Mariangela, Guttà, Cristiano, Gasparre, Giuseppe, Picardi, Ernesto, Pesole, Graziano, Attimonelli, Marcella

“…The increasing availability of mitochondria-targeted and off-target sequencing data in whole-exome and whole-genome sequencing studies (WXS and WGS) has risen…”
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Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses by Kurelac, Ivana, Iommarini, Luisa, Vatrinet, Renaud, Amato, Laura Benedetta, De Luise, Monica, Leone, Giulia, Girolimetti, Giulia, Umesh Ganesh, Nikkitha, Bridgeman, Victoria Louise, Ombrato, Luigi, Columbaro, Marta, Ragazzi, Moira, Gibellini, Lara, Sollazzo, Manuela, Feichtinger, Rene Gunther, Vidali, Silvia, Baldassarre, Maurizio, Foriel, Sarah, Vidone, Michele, Cossarizza, Andrea, Grifoni, Daniela, Kofler, Barbara, Malanchi, Ilaria, Porcelli, Anna Maria, Gasparre, Giuseppe

“…Converting carcinomas in benign oncocytomas has been suggested as a potential anti-cancer strategy. One of the oncocytoma hallmarks is the lack of respiratory…”
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Learning from oncocytic tumors: Why choose inefficient mitochondria? by Gasparre, Giuseppe, Romeo, Giovanni, Rugolo, Michela, Porcelli, Anna Maria

“…A prominent role for mitochondrial genes and metabolism has been recently characterized in oncocytic transformation of cancer cells. From mitochondrial…”
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Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer by Sansone, Pasquale, Ceccarelli, Claudio, Berishaj, Marjan, Chang, Qing, Rajasekhar, Vinagolu K., Perna, Fabiana, Bowman, Robert L., Vidone, Michele, Daly, Laura, Nnoli, Jennifer, Santini, Donatella, Taffurelli, Mario, Shih, Natalie N. C., Feldman, Michael, Mao, Jun J., Colameco , Christopher, Chen, Jinbo, DeMichele, Angela, Fabbri, Nicola, Healey, John H., Cricca, Monica, Gasparre, Giuseppe, Lyden, David, Bonafé, Massimiliano, Bromberg, Jacqueline

“…The mechanisms of metastatic progression from hormonal therapy (HT) are largely unknown in luminal breast cancer. Here we demonstrate the enrichment of CD133…”
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The reference human nuclear mitochondrial sequences compilation validated and implemented on the UCSC genome browser by Simone, Domenico, Calabrese, Francesco Maria, Lang, Martin, Gasparre, Giuseppe, Attimonelli, Marcella

“…Eukaryotic nuclear genomes contain fragments of mitochondrial DNA called NumtS (Nuclear mitochondrial Sequences), whose mode and time of insertion, as well as…”
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Inducing respiratory complex I impairment elicits an increase in PGC1α in ovarian cancer by De Luise, Monica, Sollazzo, Manuela, Lama, Eleonora, Coadă, Camelia Alexandra, Bressi, Licia, Iorio, Maria, Cavina, Beatrice, D’Angelo, Luigi, Milioni, Sara, Marchio, Lorena, Miglietta, Stefano, Coluccelli, Sara, Tedesco, Greta, Ghelli, Anna, Lemma, Silvia, Perrone, Anna Myriam, Kurelac, Ivana, Iommarini, Luisa, Porcelli, Anna Maria, Gasparre, Giuseppe

“…Anticancer strategies aimed at inhibiting Complex I of the mitochondrial respiratory chain are increasingly being attempted in solid tumors, as functional…”
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A multi-parametric workflow for the prioritization of mitochondrial DNA variants of clinical interest by Santorsola, Mariangela, Calabrese, Claudia, Girolimetti, Giulia, Diroma, Maria Angela, Gasparre, Giuseppe, Attimonelli, Marcella

“…Assigning a pathogenic role to mitochondrial DNA (mtDNA) variants and unveiling the potential involvement of the mitochondrial genome in diseases are…”
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OPA1 links human mitochondrial genome maintenance to mtDNA replication and distribution by Elachouri, Ghizlane, Vidoni, Sara, Zanna, Claudia, Pattyn, Alexandre, Boukhaddaoui, Hassan, Gaget, Karen, Yu-Wai-Man, Patrick, Gasparre, Giuseppe, Sarzi, Emmanuelle, Delettre, Cécile, Olichon, Aurélien, Loiseau, Dominique, Reynier, Pascal, Chinnery, Patrick F, Rotig, Agnès, Carelli, Valerio, Hamel, Christian P, Rugolo, Michela, Lenaers, Guy

“…Eukaryotic cells harbor a small multiploid mitochondrial genome, organized in nucleoids spread within the mitochondrial network. Maintenance and distribution…”
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Complex I impairment in mitochondrial diseases and cancer: Parallel roads leading to different outcomes by Iommarini, Luisa, Calvaruso, Maria Antonietta, Kurelac, Ivana, Gasparre, Giuseppe, Porcelli, Anna Maria

“…Respiratory chain complex I (CI) dysfunctions have been recognized as one of the most frequent causes of mitochondrial neuro-muscular disorders. Moreover,…”
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NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate by D’Angelo, Luigi, Astro, Elisa, De Luise, Monica, Kurelac, Ivana, Umesh-Ganesh, Nikkitha, Ding, Shujing, Fearnley, Ian M., Gasparre, Giuseppe, Zeviani, Massimo, Porcelli, Anna Maria, Fernandez-Vizarra, Erika, Iommarini, Luisa

“…Complex I (CI) is the largest enzyme of the mitochondrial respiratory chain, and its defects are the main cause of mitochondrial disease. To understand the…”
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Plasma-activated Ringer's Lactate Solution Displays a Selective Cytotoxic Effect on Ovarian Cancer Cells by Bisag, Alina, Bucci, Cristiana, Coluccelli, Sara, Girolimetti, Giulia, Laurita, Romolo, De Iaco, Pierandrea, Perrone, Anna Myriam, Gherardi, Matteo, Marchio, Lorena, Porcelli, Anna Maria, Colombo, Vittorio, Gasparre, Giuseppe

“…Epithelial Ovarian Cancer (EOC) is one of the leading causes of cancer-related deaths among women and is characterized by the diffusion of nodules or plaques…”
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Detecting Variants in the NBN Gene While Testing for Hereditary Breast Cancer: What to Do Next? by Zuntini, Roberta, Bonora, Elena, Pradella, Laura Maria, Amato, Laura Benedetta, Vidone, Michele, De Fanti, Sara, Catucci, Irene, Cortesi, Laura, Medici, Veronica, Ferrari, Simona, Gasparre, Giuseppe, Peterlongo, Paolo, Sazzini, Marco, Turchetti, Daniela

“…The NBN gene has been included in breast cancer (BC) multigene panels based on early studies suggesting an increased BC risk for carriers, though not confirmed…”
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Mitochondrial DNA analysis efficiently contributes to the identification of metastatic contralateral breast cancers by Girolimetti, Giulia, Marchio, Lorena, De Leo, Antonio, Mangiarelli, Miriam, Amato, Laura Benedetta, Zanotti, Simone, Taffurelli, Mario, Santini, Donatella, Gasparre, Giuseppe, Ceccarelli, Claudio

“…Purpose In daily practice, a contralateral breast cancer (CBC) is usually considered as a new independent tumor despite the indications of several studies…”
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Modulation of RAB7A Protein Expression Determines Resistance to Cisplatin through Late Endocytic Pathway Impairment and Extracellular Vesicular Secretion by Guerra, Flora, Paiano, Aurora, Migoni, Danilo, Girolimetti, Giulia, Perrone, Anna Myriam, De Iaco, Pierandrea, Fanizzi, Francesco Paolo, Gasparre, Giuseppe, Bucci, Cecilia

“…Cisplatin (CDDP) is widely used in treatment of cancer, yet patients often develop resistance with consequent therapeutical failure. In CDDP-resistant cells…”
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HmtDB, a genomic resource for mitochondrion-based human variability studies by Rubino, Francesco, Piredda, Roberta, Calabrese, Francesco Maria, Simone, Domenico, Lang, Martin, Calabrese, Claudia, Petruzzella, Vittoria, Tommaseo-Ponzetta, Mila, Gasparre, Giuseppe, Attimonelli, Marcella

“…HmtDB (http://www.hmtdb.uniba.it:8080/hmdb) is a open resource created to support population genetics and mitochondrial disease studies. The database hosts…”
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Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors by Gasparre, Giuseppe, Porcelli, Anna Maria, Bonora, Elena, Pennisi, Lucia Fiammetta, Toller, Matteo, Iommarini, Luisa, Ghelli, Anna, Moretti, Massimo, Betts, Christine M, Martinelli, Giuseppe Nicola, Ceroni, Alberto Rinaldi, Curcio, Francesco, Carelli, Valerio, Rugolo, Michela, Tallini, Giovanni, Romeo, Giovanni

“…Oncocytic tumors are a distinctive class of proliferative lesions composed of cells with a striking degree of mitochondrial hyperplasia that are particularly…”
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Mice harbouring a SCA28 patient mutation in AFG3L2 develop late-onset ataxia associated with enhanced mitochondrial proteotoxicity by Mancini, Cecilia, Hoxha, Eriola, Iommarini, Luisa, Brussino, Alessandro, Richter, Uwe, Montarolo, Francesca, Cagnoli, Claudia, Parolisi, Roberta, Gondor Morosini, Diana Iulia, Nicolò, Valentina, Maltecca, Francesca, Muratori, Luisa, Ronchi, Giulia, Geuna, Stefano, Arnaboldi, Francesca, Donetti, Elena, Giorgio, Elisa, Cavalieri, Simona, Di Gregorio, Eleonora, Pozzi, Elisa, Ferrero, Marta, Riberi, Evelise, Casari, Giorgio, Altruda, Fiorella, Turco, Emilia, Gasparre, Giuseppe, Battersby, Brendan J., Porcelli, Anna Maria, Ferrero, Enza, Brusco, Alfredo, Tempia, Filippo

“…Spinocerebellar ataxia 28 is an autosomal dominant neurodegenerative disorder caused by missense mutations affecting the proteolytic domain of AFG3L2, a major…”
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