Search Results - "Gaspar, Luciane P."

Structure of the Ebola Fusion Peptide in a Membrane-mimetic Environment and the Interaction with Lipid Rafts by Freitas, Mônica S., Gaspar, Luciane P., Lorenzoni, Marcos, Almeida, Fabio C.L., Tinoco, Luzineide W., Almeida, Marcius S., Maia, Lenize F., Degrève, Léo, Valente, Ana Paula, Silva, Jerson L.

“…The fusion peptide EBO16 (GAAIGLAWIPYFGPAA) comprises the fusion domain of an internal sequence located in the envelope fusion glycoprotein (GP2) of the Ebola…”
Get full text

Purification of yellow fever virus produced in Vero cells for inactivated vaccine manufacture by Pato, Tânia P., Souza, Marta C.O., Mattos, Diogo A., Caride, Elena, Ferreira, Davis F., Gaspar, Luciane P., Freire, Marcos S., Castilho, Leda R.

“…Yellow fever (YF) is a high-lethality viral disease, endemic in tropical regions of South America and Africa, with a population of over 900 million people…”
Get full text

Increasing Vero viable cell densities for yellow fever virus production in stirred-tank bioreactors using serum-free medium by Mattos, Diogo A, Silva, Marlon V, Gaspar, Luciane P, Castilho, Leda R

“…Abstract In this work, changes in Vero cell cultivation methods have been employed in order to improve cell growth conditions to obtain higher viable cell…”
Get full text

An inactivated yellow fever 17DD vaccine cultivated in Vero cell cultures by Pereira, Renata C, Silva, Andrea N.M.R, Souza, Marta Cristina O, Silva, Marlon V, Neves, Patrícia P.C.C, Silva, Andrea A.M.V, Matos, Denise D.C.S, Herrera, Miguel A.O, Yamamura, Anna M.Y, Freire, Marcos S, Gaspar, Luciane P, Caride, Elena

“…Abstract Yellow fever is an acute infectious disease caused by prototype virus of the genus Flavivirus . It is endemic in Africa and South America where it…”
Get full text

Hydrostatic Pressure Induces the Fusion-active State of Enveloped Viruses by Gaspar, Luciane P., Silva, Ana C.B., Gomes, Andre M.O., Freitas, Mônica S., Ano Bom, Ana P.D., Schwarcz, Waleska D., Mestecky, Jiri, Novak, Miroslav J., Foguel, Débora, Silva, Jerson L.

“…Enveloped animal viruses must undergo membrane fusion to deliver their genome into the host cell. We demonstrate that high pressure inactivates two…”
Get full text

Development of a membrane adsorber based capture step for the purification of yellow fever virus by Pato, Tânia P, Souza, Marta Cristina O, Silva, Andréa N.M.R, Pereira, Renata C, Silva, Marlon V, Caride, Elena, Gaspar, Luciane P, Freire, Marcos S, Castilho, Leda R

“…Abstract Yellow fever (YF) is an endemic disease in some tropical areas of South America and Africa that presents lethality rate between 20 and 50%. There is…”
Get full text

Production of yellow fever virus in microcarrier-based Vero cell cultures by Souza, Marta Cristina O, Freire, Marcos S, Schulze, Erica A, Gaspar, Luciane P, Castilho, Leda R

“…Abstract In this work, the propagation of the 17DD yellow fever virus in Vero cells grown on Cytodex-1 microcarriers was evaluated. After verifying that upon…”
Get full text

Pressure-inactivated yellow fever 17DD virus: Implications for vaccine development by Gaspar, Luciane P., Mendes, Ygara S., Yamamura, Anna M.Y., Almeida, Luiz F.C., Caride, Elena, Gonçalves, Rafael B., Silva, Jerson L., Oliveira, Andréa C., Galler, Ricardo, Freire, Marcos S.

“…The successful Yellow Fever (YF) vaccine consists of the live attenuated 17D-204 or 17DD viruses. Despite its excellent record of efficacy and safety, serious…”
Get full text

Effects of hydrostatic pressure on the stability and thermostability of poliovirus: A new method for vaccine preservation by Ferreira, Evanilce, Mendes, Ygara S, Silva, Jerson L, Galler, Ricardo, Oliveira, Andréa C, Freire, Marcos S, Gaspar, Luciane P

“…Abstract Viruses are a structurally diverse group of infectious agents that differ widely in their sensitivities to high hydrostatic pressure (HHP). Studies on…”
Get full text

The Metastable State of Nucleocapsids of Enveloped Viruses as Probed by High Hydrostatic Pressure by Gaspar, Luciane P., Terezan, Alexandre F., Pinheiro, Anderson S., Foguel, Débora, Rebello, Moacyr A., Silva, Jerson L.

“…Enveloped viruses fuse their membranes with cellular membranes to transfer their genomes into cells at the beginning of infection. What is not clear, however,…”
Get full text

The fusogenic state of Mayaro virus induced by low pH and by hydrostatic pressure by Freitas, Monica, Da Poian, Andrea T, Barth, Ortrud M, Rebello, Moacyr A, Silva, Jerson L, Gaspar, Luciane P

“…Mayaro virus is an enveloped virus that belongs to the Alphavirus genus. To gain insight into the mechanism involved in Mayaro virus membrane fusion, we used…”
Get full text

Partially folded states of the capsid protein of cowpea severe mosaic virus in the disassembly pathway by Gaspar, Luciane P, Johnson, John E, Silva, Jerson L, Da Poian, Andrea T

“…The different partially folded states of the capsid protein that appear in the disassembly pathway of cowpea severe mosaic virus (CPSMV) were investigated by…”
Get full text

Arc repressor will not denature under pressure in the absence of water by Oliveira, A C, Gaspar, L P, Da Poian, A T, Silva, J L

“…Hydration forces are believed to play a determining role in protein folding. We have examined the contribution of water for the stability of the native dimer…”
Get more information

Reversible pressure dissociation of R17 bacteriophage. The physical individuality of virus particles by Da Poian, A T, Oliveira, A C, Gaspar, L P, Silva, J L, Weber, G

“…In the absence of urea, pressures up to 2.5 kbar promote only 10% dissociation of the whole particles of R17 bacteriophage. In the presence of concentrations…”
Get more information