Search Results - "Gaspar, Claudia"
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Impact of wildfire on water quality in Caramulo Mountain ridge (Central Portugal)
Published in Sustainable water resources management (07-03-2019)“…Fire is a major ecosystem process affecting forests and wooded areas in the Mediterranean basin. In recent years, a clear increase in wildfires in Portugal has…”
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2
Genetics of familial and sporadic amyotrophic lateral sclerosis
Published in Biochimica et biophysica acta (01-11-2006)“…Diseases affecting motor neurons, such as amyotrophic lateral sclerosis (Lou Gerhig's disease), hereditary spastic paraplegia and spinal bulbar muscular…”
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3
cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo
Published in Proceedings of the National Academy of Sciences - PNAS (20-05-2008)“…Tissue engineering of large bone defects is approached through implantation of autologous osteogenic cells, generally referred to as multipotent stromal cells…”
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Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation
Published in PLoS genetics (01-05-2013)“…Canonical Wnt signaling plays a rate-limiting role in regulating self-renewal and differentiation in mouse embryonic stem cells (ESCs). We have previously…”
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APC and Oncogenic KRAS Are Synergistic in Enhancing Wnt Signaling in Intestinal Tumor Formation and Progression
Published in Gastroenterology (New York, N.Y. 1943) (01-10-2006)“…Background & Aims: Synchronous activation of the Wnt signaling pathway, mostly because of loss of function of the APC tumor suppressor, and of the oncogenic…”
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6
Two Notch ligands, Dll1 and Jag1, are differently restricted in their range of action to control neurogenesis in the mammalian spinal cord
Published in PloS one (24-11-2010)“…Notch signalling regulates neuronal differentiation in the vertebrate nervous system. In addition to a widespread function in maintaining neural progenitors,…”
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7
Following butter flavour deterioration with an acoustic wave sensor
Published in Talanta (Oxford) (15-09-2012)“…Off-flavours develop naturally in butter and the process is accelerated by heat. An acoustic wave sensor was used to detect the aroma compounds evolved from…”
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8
A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis
Published in PLoS genetics (01-07-2009)“…Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary…”
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Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells
Published in Bone (New York, N.Y.) (01-05-2004)“…Human mesenchymal stem cells (hMSCs) from the bone marrow represent a potential source of pluripotent cells for autologous bone tissue engineering. We…”
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10
APC dosage effects in tumorigenesis and stem cell differentiation
Published in The International journal of developmental biology (2004)“…It is well established that concentration gradients of signaling molecules (the so-called "morphogens") organize and pattern tissues in developing animals. In…”
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11
Cross-Species Comparison of Human and Mouse Intestinal Polyps Reveals Conserved Mechanisms in Adenomatous Polyposis Coli ( APC )-Driven Tumorigenesis
Published in The American journal of pathology (01-05-2008)“…Expression profiling is a well established tool for the genome-wide analysis of human cancers. However, the high sensitivity of this approach combined with the…”
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12
(No) Oral Health in Palliative Care Patients: Predisposing Factors and Treatment
Published in Journal of palliative care (20-11-2023)“…Objective To describe mouth disorders in patients undergoing palliative care (PC); to identify predisposing factors for oral disorders and pharmacological and…”
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13
Transgenic expression of an expanded (GCG) 13 repeat PABPN1 leads to weakness and coordination defects in mice
Published in Neurobiology of disease (01-04-2005)“…Oculopharyngeal muscular dystrophy (OPMD) is a late-onset disorder caused by a (GCG) n trinucleotide repeat expansion in the poly(A) binding protein nuclear-1…”
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14
Context-dependent functional divergence of the notch ligands DLL1 and DLL4 In Vivo
Published in PLoS genetics (01-06-2015)“…Copyright: © 2015 Preuße et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits…”
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15
Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling
Published in Neurobiology of disease (01-11-2020)“…Rett syndrome (RTT; OMIM#312750) is mainly caused by mutations in the X-linked MECP2 gene (methyl-CpG-binding protein 2 gene; OMIM*300005), which leads to…”
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Hello! How can I help you? The role of telephone consultation in palliative care for patients at home
Published in Motricidade (31-03-2024)“…This work aims to describe and analyse the telephone consultation (TC) for palliative care (PC) patients at home and their caregivers provided by a PC team in…”
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Young but not Naive: Leaders of Tomorrow Expect Limits to Digital Freedom to Preserve Freedom
Published in NIM Marketing Intelligence Review (01-05-2021)“…In a recent survey, about 900 “Leaders of Tomorrow” from more than 90 countries all over the world shared their opinions about “the impact of new technologies…”
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Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells
Published in Biotechnology journal (01-10-2015)“…Standardization of culture methods for human pluripotent stem cell (PSC) neural differentiation can greatly contribute to the development of novel clinical…”
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Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo: e1005328
Published in PLoS genetics (01-06-2015)“…Notch signalling is a fundamental pathway that shapes the developing embryo and sustains adult tissues by direct communication between ligand and receptor…”
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20
Trophic ecology of northern gannets Morus bassanus highlights the extent of isotopic niche overlap with other apex predators within the Bay of Biscay
Published in Marine biology (01-08-2022)“…Understanding the linkages within complex and evolving marine food webs is essential to comprehend marine ecosystem structure and dynamics. Carbon (δ 13 C) and…”
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