Search Results - "Gasic, Vladimir"
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Clinical Application of Thiopurine Pharmacogenomics in Pediatrics
Published in Current drug metabolism (01-01-2020)“…Thiopurine drugs are used for the treatment of pediatric diseases. Inter-individual differences in the metabolism of these drugs greatly influence the risk of…”
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Diagnostic and Therapeutic Implications of Long Non-Coding RNAs in Leukemia
Published in Life (Basel, Switzerland) (01-11-2022)“…Leukemia is a heterogenous group of hematological malignancies categorized in four main types (acute myeloid leukemia (AML), acute lymphoblastic leukemia…”
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The long non-coding RNA GAS5 contributes to the suppression of inflammatory responses by inhibiting NF-κB activity
Published in Frontiers in pharmacology (09-10-2024)“…Nuclear factor kappa B (NF-κB) is a key regulator of immune and inflammatory responses. Glucocorticoid drugs (GC) act through the glucocorticoid receptor (GR)…”
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Genome-Wide Association Study of COVID-19 Outcomes Reveals Novel Host Genetic Risk Loci in the Serbian Population
Published in Frontiers in genetics (14-07-2022)“…Host genetics, an important contributor to the COVID-19 clinical susceptibility and severity, currently is the focus of multiple genome-wide association…”
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The influence of BCL2, BAX, and ABCB1 gene expression on prognosis of adult de novo acute myeloid leukemia with normal karyotype patients
Published in Radiology and oncology (01-06-2023)“…Deregulation of the apoptotic process underlies the pathogenesis of many cancers, including leukemia, but is also very important for the success of…”
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Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity
Published in Frontiers in nutrition (Lausanne) (04-06-2021)“…Background: COVID-19 pandemic has proved to be an unrelenting health threat for more than a year now. The emerging amount of data indicates that vitamin D,…”
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Expression Profiles of Long Non-Coding RNA GAS5 and MicroRNA-222 in Younger AML Patients
Published in Diagnostics (Basel) (30-12-2021)“…Acute myeloid leukemia (AML) is a heterogeneous malignant disease both on clinical and genetic levels. AML has poor prognosis and, therefore, there is a…”
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Pharmacogenomic markers of glucocorticoid response in the initial phase of remission induction therapy in childhood acute lymphoblastic leukemia
Published in Radiology and oncology (11-09-2018)“…Background Response to glucocorticoid (GC) monotherapy in the initial phase of remission induction treatment in childhood acute lymphoblastic leukemia (ALL)…”
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Can pharmacogenetics impact the therapeutic effect of cytarabine and anthracyclines in adult acute myeloid leukaemia patients?: A Serbian experience
Published in Journal of medical biochemistry (15-06-2024)“…Cytarabine-anthracycline-based induction chemotherapy remains the standard of care for remission induction among patients with newly diagnosed acute myeloid…”
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The pharmacogenomics of vincristine-induced peripheral neuropathy in pediatric acute lymphoblastic leukemia patients in Serbia - a single center experience
Published in Srpski arhiv za celokupno lekarstvo (2022)“…Introduction/Objective. Vincristine (VCR) is one of the key drugs in current treatment protocols for pediatric acute lymphoblastic leukemia (ALL). By…”
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Genetic basis of otosclerosis
Published in Srpski arhiv za celokupno lekarstvo (01-09-2020)“…Introduction. Otosclerosis is a disorder of the bone labyrinth and stapes resulting in conductive hearing loss. The genetic basis of otosclerosis still remains…”
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Association of variants in AGTR1, ACE, MTHFR genes with microalbuminuria and risk factors for the onset of diabetic nephropathy in adolescents with type 1 diabetes in the population of Serbia
Published in PloS one (24-10-2024)“…Genetic studies may provide valuable information about patients who are at high risk of developing diabetes nephropathy. Before the appearance of albuminuria,…”
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Pharmacogenomics landscape of COVID-19 therapy response in Serbian population and comparison with worldwide populations
Published in Journal of medical biochemistry (01-01-2020)“…Since there are no certified therapeutics to treat COVID-19 patients, drug repurposing became important. With lack of time to test individual pharmacogenomics…”
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Genetic predictors of celiac disease, lactose intolerance, and vitamin D function and presence of peptide morphins in urine of children with neurodevelopmental disorders
Published in Nutritional neuroscience (02-01-2019)“…Gastrointestinal disturbances, nutritional deficiencies, and food intolerances are frequently observed in children with neurodevelopmental disorders (NDD). To…”
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Expression pattern of long non-coding RNA growth arrest-specific 5 in the remission induction therapy in childhood acute lymphoblastic leukemia
Published in Journal of medical biochemistry (01-07-2019)“…Long non-coding RNA growth arrest-specific 5 ( ) is deregulated in many cancers because of its role in cell growth arrest and apoptosis. Additionally,…”
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Functional prediction and comparative population analysis of variants in genes for proteases and innate immunity related to SARS-CoV-2 infection
Published in Infection, genetics and evolution (01-10-2020)“…New coronavirus SARS-CoV-2 is capable to infect humans and cause a novel disease COVID-19. Aiming to understand a host genetic component of COVID-19, we…”
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Machine Learning Modeling from Omics Data as Prospective Tool for Improvement of Inflammatory Bowel Disease Diagnosis and Clinical Classifications
Published in Genes (18-09-2021)“…Research of inflammatory bowel disease (IBD) has identified numerous molecular players involved in the disease development. Even so, the understanding of IBD…”
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Pharmacogenomic and Pharmacotranscriptomic Profiling of Childhood Acute Lymphoblastic Leukemia: Paving the Way to Personalized Treatment
Published in Genes (01-03-2019)“…Personalized medicine is focused on research disciplines which contribute to the individualization of therapy, like pharmacogenomics and…”
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