Search Results - "Gash, D.M."

Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques by Stenslik, M.J., Evans, A., Pomerleau, F., Weeks, R., Huettl, P., Foreman, E., Turchan-Cholewo, J., Andersen, A., Cass, W.A., Zhang, Z., Grondin, R.C., Gash, D.M., Gerhardt, G.A., Bradley, L.H.

“…•DNSP-11 was repeatedly delivered intranasally in awake Rhesus over 10-weeks.•Neurochemical analysis of the striatum provided evidence for target…”
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Validations of apomorphine-induced BOLD activation correlations in hemiparkinsonian rhesus macaques by Quintero, J E, Ai, Yi, Andersen, A H, Hardy, P, Grondin, R, Guduru, Z, Gash, D M, Gerhardt, G A, Zhang, Z

“…Identification of Parkinson's disease at the earliest possible stage of the disease may provide the best opportunity for the use of disease modifying…”
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2.150 A POSSIBLE NEW BIOMARKER FOR PARKINSON'S DISEASE: PHARMACOLOGICAL MRI (PHMRI) TO DISCRIMINATE ANIMALS WITH MPTP-VERSUS AGE-RELATED PARKINSONISM IN RHESUS MONKEYS by Zhang, Z, Andersen, A, Hardy, P, Ai, Y, Grondin, R, Gash, D.M, Gerhardt, G.A

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A synthetic five amino acid propeptide increases dopamine neuron differentiation and neurochemical function by Littrell, O.M, Fuqua, J.L, Richardson, A.D, Turchan-Cholewo, J, Hascup, E.R, Huettl, P, Pomerleau, F, Bradley, L.H, Gash, D.M, Gerhardt, G.A

“…Abstract A major consequence of Parkinson’s disease (PD) involves the loss of dopaminergic neurons in the substantia nigra (SN) and a subsequent loss of…”
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Critical decline in fine motor hand movements in human aging by SMITH, C. D, UMBERGER, G. H, GASH, D. M, MANNING, E. L, SLEVIN, J. T, WEKSTEIN, D. R, SCHMITT, F. A, MARKESBERY, W. R, ZHANG, Z, GERHARDT, G. A, KRYSCIO, R. J

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Disruption of the blood-brain barrier as the primary effect of CNS irradiation by Rubin, P, Gash, D M, Hansen, J T, Nelson, D F, Williams, J P

“…The blood-brain barrier (BBB) is believed to be unique in organ microcirculation due to the 'tight junctions' which exist between endothelial cells and, some…”
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Topographical distribution of [ 125I]-glial cell line-derived neurotrophic factor in unlesioned and MPTP-lesioned rhesus monkey brain following a bolus intraventricular injection by Lapchak, P.A, Araujo, D.M, Hilt, D.C, Jiao, S, Collin, F, Miyoshi, Y, Yi, A, Zhang, Z, Gash, D.M

“…The present study determined the topographical distribution profile for [ 125I]-glial cell line-derived neurotrophic factor in unlesioned and MPTP-lesioned…”
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Memories that last in old age: motor skill learning and memory preservation by Smith, C.D., Walton, A., Loveland, A.D., Umberger, G.H., Kryscio, R.J., Gash, D.M.

“…Using an automated test panel, age-associated declines in learning, remembering and performing a novel visuomotor task were assessed in 497 normal adults…”
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Fenbendazole treatment may influence lipopolysaccharide effects in rat brain by Hunter, R.L, Choi, D.Y, Kincer, J.F, Cass, W.A, Bing, G, Gash, D.M

“…In evaluating discrepant results between experiments in our laboratory, we collected data that challenge the notion that anthelminthic drugs like FBZ do not…”
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Time course of the neuroprotective effect of transplantation on quinolinic acid-induced lesions of the striatum by Levivier, M., Gash, D.M., Przedborski, S.

“…Injection of quinolinic acid in the rat striatum mimics neurochemical changes observed in Huntington's disease. We previously demonstrated that intrastriatal…”
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Mapping drug-induced changes in cerebral [formula omitted] by Multiple Gradient Recalled Echo functional MRI by Chen, Q., Andersen, A.H., Zhang, Z., Ovadia, A., Gash, D.M., Avison, M.J.

“…A Multiple Gradient Recalled Echo MRI sequence was used to map spatial and temporal changes in the rate of MR signal decay ( R 2 ∗ ) in response to…”
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Developing a stable bilateral model of parkinsonism in rhesus monkeys by Smith, R D, Zhang, Z, Kurlan, R, McDermott, M, Gash, D M

“…The non-human primate models of Parkinson's disease which have been developed using the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine) have…”
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Cografts of adrenal medulla with C6 glioma cells in rats with 6-hydroxydopamine-induced lesions by Bing, G, Notter, M F, Hansen, J T, Kellogg, C, Kordower, J H, Gash, D M

“…Amitotic [3H]thymidine-labeled C6 glioma cells, which are known to produce neurotrophic factor(s), were grafted alone and with adrenal chromaffin cells in an…”
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Rodent and primate adrenal medullary cells in vitro: phenotypic plasticity in response to coculture with C6 glioma cells or NGF by NOTTER, M. F. D, HANSEN, J. T, OKAWARA, S, GASH, D. M

“…In order to maintain a chronic supply of growth factor for medulla cells in vitro, chromaffin cells from rat, African green monkeys and man were co-cultured…”
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Amitotic Neuroblastoma Cells used for Neural Implants in Monkeys by Gash, D. M., Notter, M. F. D., Okawara, S. H., Kraus, A. L., Joynt, R. J.

“…The potential utility of cultured neuroblastoma cells as donor tissue for neural implants into the mammalian brain has been examined. Cells from a human…”
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Retinal transplants into the anterior chamber of the rat eye by del Cerro, M, Gash, D M, Rao, G N, Notter, M F, Wiegand, S J, Sathi, S, del Cerro, C

“…Developing retinas from 13-18-day fetuses and 2-day neonatal Long-Evans rats transplanted into the anterior chamber of adult eyes of the same or different…”
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MPTP alters central catecholamine neurons in addition to the nigrostriatal system by Gupta, M, Felten, D L, Gash, D M

“…The present studies were undertaken to determine if MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) treatment in mice alters catecholamine or serotonin…”
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Fetal hypothalamic transplants into brain irradiated rats: graft morphometry and host behavioral responses by Pearlman, S H, Rubin, P, White, H C, Wiegand, S J, Gash, D M

“…This study was designed to test the hypothesis that neural implants can ameliorate or prevent some of the long-term changes associated with CNS irradiation…”
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Vasopressin neuron survival in neonatal Brattleboro rats; critical factors in graft development and innervation of the host brain by Boer, G J, Gash, D M, Dick, L, Schluter, N

“…Previously it was found that grafts of supraoptic plus paraventricular areas from 19-day-old foetal normal rats survived in the third ventricle of the brain of…”
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Synapse-competence of LA-N-2 human neuroblastoma cells in coculture with rat striated muscle cells by Yeh, H H, Notter, M F, Kordowerr, J H, Gash, D M

“…The purpose of this study was to determine whether cells of the human neuroblastoma line, LA-N-2, are capable of establishing functional synapses in culture…”
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