Search Results - "Gasek, Nathan S"

The heterogeneity of cellular senescence: insights at the single-cell level by Cohn, Rachel L., Gasek, Nathan S., Kuchel, George A., Xu, Ming

“…Senescent cells are highly associated with aging and pathological conditions and could be targeted to slow the aging process. One commonly used marker to…”
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Role of Senescent Cells in Cutaneous Wound Healing by Andrade, Allison M, Sun, Mingda, Gasek, Nathan S, Hargis, Geneva R, Sharafieh, Roshanak, Xu, Ming

“…Cellular senescence has gained increasing attention in the field of aging research. Senescent cells have been implicated in biological aging processes,…”
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Strategies for Targeting Senescent Cells in Human Disease by Gasek, Nathan S, Kuchel, George A, Kirkland, James L, Xu, Ming

“…Cellular senescence represents a distinct cell fate characterized by replicative arrest in response to a host of extrinsic and intrinsic stresses. Senescence…”
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The Contributions of the Amino and Carboxy Terminal Domains of Flightin to the Biomechanical Properties of Drosophila Flight Muscle Thick Filaments by Gasek, Nathan S, Nyland, Lori R, Vigoreaux, Jim O

“…Flightin is a myosin binding protein present in Pancrustacea. In Drosophila, flightin is expressed in the indirect flight muscles (IFM), where it is required…”
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An inducible p21 -Cre mouse model to monitor and manipulate p21 -highly-expressing senescent cells in vivo by Wang, Binsheng, Wang, Lichao, Gasek, Nathan S, Zhou, Yueying, Kim, Taewan, Guo, Chun, Jellison, Evan R, Haynes, Laura, Yadav, Sumit, Tchkonia, Tamar, Kuchel, George A, Kirkland, James L, Xu, Ming

“…The role of senescent cells has been implicated in various tissue dysfunction associated with aging, obesity, and other pathological conditions. Currently,…”
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Senolytics alleviate the degenerative disorders of temporomandibular joint in old age by Zhou, Yueying, Al‐Naggar, Iman M. A., Chen, Po‐Jung, Gasek, Nathan S., Wang, Ke, Mehta, Shivam, Kuchel, George A., Yadav, Sumit, Xu, Ming

“…Aging is one of the major risk factors for degenerative joint disorders, including those involving the temporomandibular joint (TMJ). TMJ degeneration occurs…”
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Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function by Wang, Binsheng, Wang, Lichao, Gasek, Nathan S, Kuo, Chia-Ling, Nie, Jia, Kim, Taewan, Yan, Pengyi, Zhu, Junyu, Torrance, Blake L, Zhou, Yueying, Flores, Lisa C, Allen, Colton, Andrade, Allison M, Guo, Chun, Cohn, Rachel L, Jellison, Evan R, Bartley, Jenna M, Kuchel, George A, Li, Sheng, Pirtskhalava, Tamar, Tchkonia, Tamar, Yadav, Sumit, Haynes, Laura, Kirkland, James L, Ikeno, Yuji, Xu, Ming

“…A key challenge in aging research is extending lifespan in tandem with slowing down functional decline so that life with good health (healthspan) can be…”
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Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity by Wang, Lichao, Wang, Binsheng, Gasek, Nathan S., Zhou, Yueying, Cohn, Rachel L., Martin, Dominique E., Zuo, Wulin, Flynn, William F., Guo, Chun, Jellison, Evan R., Kim, Taewan, Langhi Prata, Larissa G.P., Palmer, Allyson K., Li, Ming, Inman, Christina L., Barber, Lauren S., Al-Naggar, Iman M.A., Zhou, Yanjiao, Du, Wenqiang, Kshitiz, Kuchel, George A., Meves, Alexander, Tchkonia, Tamar, Kirkland, James L., Robson, Paul, Xu, Ming

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Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity by Wang, Lichao, Wang, Binsheng, Gasek, Nathan S., Zhou, Yueying, Cohn, Rachel L., Martin, Dominique E., Zuo, Wulin, Flynn, William F., Guo, Chun, Jellison, Evan R., Kim, Taewan, Prata, Larissa G.P. Langhi, Palmer, Allyson K., Li, Ming, Inman, Christina L., Barber, Lauren S., Al-Naggar, Iman M.A., Zhou, Yanjiao, Du, Wenqiang, Kshitiz, Kuchel, George A., Meves, Alexander, Tchkonia, Tamar, Kirkland, James L., Robson, Paul, Xu, Ming

“…Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2 diabetes. Limited mechanism-based…”
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Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing by Gasek, Nathan S., Yan, Pengyi, Zhu, Junyu, Purushothaman, K-Raman, Kim, Taewan, Wang, Lichao, Wang, Binsheng, Flynn, William F., Sun, Mingda, Guo, Chun, Huggins, Billy, Sharafieh, Roshanak, Zhou, Yueying, Parizek, Vojtech, Tchkonia, Tamar, Kirkland, James L., Wyles, Saranya P., Xu, Ming

“…While senescent cells have detrimental roles in several contexts, they are highly heterogeneous. p16 highly expressing senescent cells have been reported to…”
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Targeting p21 Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity by Wang, Lichao, Wang, Binsheng, Gasek, Nathan S, Zhou, Yueying, Cohn, Rachel L, Martin, Dominique E, Zuo, Wulin, Flynn, William F, Guo, Chun, Jellison, Evan R, Kim, Taewan, Langhi Prata, Larissa G P, Palmer, Allyson K, Li, Ming, Inman, Christina L, Barber, Lauren S, Al-Naggar, Iman M A, Zhou, Yanjiao, Du, Wenqiang, Kshitiz, Kuchel, George A, Meves, Alexander, Tchkonia, Tamar, Kirkland, James L, Robson, Paul, Xu, Ming

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Targeting p21 Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity by Wang, Lichao, Wang, Binsheng, Gasek, Nathan S, Zhou, Yueying, Cohn, Rachel L, Martin, Dominique E, Zuo, Wulin, Flynn, William F, Guo, Chun, Jellison, Evan R, Kim, Taewan, Prata, Larissa G P Langhi, Palmer, Allyson K, Li, Ming, Inman, Christina L, Barber, Lauren S, Al-Naggar, Iman M A, Zhou, Yanjiao, Du, Wenqiang, Kshitiz, Kuchel, George A, Meves, Alexander, Tchkonia, Tamar, Kirkland, James L, Robson, Paul, Xu, Ming

“…Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2 diabetes. Limited mechanism-based…”
Get full text