Search Results - "Gascon, A R"

Short- and long-term stability study of lyophilized solid lipid nanoparticles for gene therapy by del Pozo-Rodríguez, A., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Most studies in gene therapy are focused on developing more efficient non-viral vectors, ignoring their stability, even though physically and chemically stable…”
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A proline-rich peptide improves cell transfection of solid lipid nanoparticle-based non-viral vectors by del Pozo-Rodríguez, A., Pujals, S., Delgado, D., Solinís, M.A., Gascón, A.R., Giralt, E., Pedraz, J.L.

“…The aim of this work was to improve the transfection efficacy of solid lipid nanoparticle (SLN)-based non-viral vectors into ARPE-19 cells through the addition…”
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Biocompatible oligochitosans as cationic modifiers of alginate/Ca microcapsules by Orive, G., Bartkowiak, A., Lisiecki, S., De Castro, M., Hernández, R. M., Gascòn, A. R., Pedraz, J. L.

“…In the past, it has been proven that by properly adjusting the molecular mass of the oligochitosan samples, it is possible to optimize the formation of rigid,…”
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Pharmacokinetic–pharmacodynamic evaluation of daptomycin, tigecycline, and linezolid versus vancomycin for the treatment of MRSA infections in four western European countries by Canut, A., Isla, A., Betriu, C., Gascón, A. R.

“…Purpose To evaluate the usefulness of daptomycin, tigecycline, and linezolid for the treatment of MRSA infection compared with vancomycin in Belgium, the…”
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Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres by Gutierro, I, Hernández, R.M, Igartua, M, Gascón, A.R, Pedraz, J.L

“…BSA was entrapped in particles of different sizes (200, 500 and 1000 nm) prepared from poly( d, l-lactic-co-glycolic) acid by a double emulsion method. The…”
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Solid lipid nanoparticles for retinal gene therapy: Transfection and intracellular trafficking in RPE cells by del Pozo-Rodríguez, A., Delgado, D., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Retinal pigment epithelial (RPE) cells are usually employed to study DNA systems for diseases related to problems in the retina. Solid lipid nanoparticles…”
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Solid lipid nanoparticles: Formulation factors affecting cell transfection capacity by del Pozo-Rodríguez, A., Delgado, D., Solinís, M.A., Gascón, A.R., Pedraz, J.L.

“…Since solid lipid nanoparticles (SLNs) were introduced as non-viral transfection systems, very few reports of their use for gene delivery have been published…”
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Biocompatibility Evaluation of Different Alginates and Alginate-Based Microcapsules by Orive, G, Carcaboso, A. M, Hernández, R. M, Gascón, A. R, Pedraz, J. L

“…Biocompatibility of biomaterials and biomaterial-based medical devices is a critical issue for the long-term function on multiple therapeutic systems. In the…”
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Biocompatibility of microcapsules for cell immobilization elaborated with different type of alginates by Orive, G, Ponce, S, Hernández, R.M, Gascón, A.R, Igartua, M, Pedraz, J.L

“…The biocompatibility of alginate-PLL-alginate (APA) microcapsules has been evaluated with respect to impurity levels. The impurity content of three different…”
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Novel extended-release formulation of lovastatin by one-step melt granulation: In vitro and in vivo evaluation by Ochoa, L., Igartua, M., Hernández, R.M., Gascón, A.R., Solinis, M.A., Pedraz, J.L.

“…The novel extended-release formulation of lovastatin developed exhibits zero-order release in vitro and provides extended plasma levels of lovastatin and its…”
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In vivo evaluation of EPO-secreting cells immobilized in different alginate-PLL microcapsules by Ponce, S., Orive, G., Hernández, R.M., Gascón, A.R., Canals, J.M., Muñoz, M.T., Pedraz, J.L.

“…Alginates are the most employed biomaterials for cell encapsulation due to their abundance, easy gelling properties and apparent biocompatibility. However, as…”
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Influence of Formulation Variables on the In-Vitro Release of Albumin from Biodegradable Microparticulate Systems by Igartua, M., Hernandez, R. M., Esquisabel, A., Gascon, A. R., Calvo, M. B., Pedraz, J. L.

“…Abstract Poly(D, L-lactide-co-glycolide) microspheres containing BSA were prepared by a modified solvent evaporation method using a double emulsion. These…”
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History, challenges and perspectives of cell microencapsulation by Orive, Gorka, Maria Hernández, Rose, Rodrı́guez Gascón, Alicia, Calafiore, Riccardo, Swi Chang, Thomas Ming, Vos, Paul de, Hortelano, Gonzalo, Hunkeler, David, Lacı́k, Igor, Luis Pedraz, José

“…Cell microencapsulation continues to hold significant promise for biotechnology and medicine. The controlled, and continuous, delivery of therapeutic products…”
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Controversies over stem cell research by Orive, Gorka, Hernández, Rosa M., Gascón, Alicia R., Igartua, Manoli, Pedraz, José Luis

“…Much interest and effort has focused on the therapeutic potential of stem cell technology to treat presently intractable diseases. However, this scientific…”
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Drug delivery in biotechnology: present and future by Orive, Gorka, Hernández, Rosa Maria, Gascón, Alicia Rodrı́guez, Domı́nguez-Gil, Alfonso, Pedraz, José Luis

“…Drug delivery is becoming a whole interdisciplinary and independent field of research and is gaining the attention of pharmaceutical makers, medical doctors…”
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Synthesis and in Vitro Anti-Mycobacterium Activity of N-Alkyl-1,2-dihydro-2-thioxo-3-pyridinecarbothioamides. Preliminary Toxicity and Pharmacokinetic Evaluation by Pagani, Giuseppe, Pregnolato, Massimo, Ubiali, Daniela, Terreni, Marco, Piersimoni, Claudio, Scaglione, Francesco, Fraschini, Franco, Gascón, Alicia Rodríguez, Pedraz Muñoz, José Luis

“…Disseminated infections with Mycobacterium tuberculosis (MT) and Mycobacterium avium complex (MAC) are increasingly opportunistic diseases in patients with…”
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Survival of different cell lines in alginate-agarose microcapsules by Orive, G, Hernández, R.M, Gascón, A.R, Igartua, M, Pedraz, J.L

“…Cell microencapsulation has emerged as a promising therapeutic strategy to treat a wide range of diseases. The optimisation of this technology depends on…”
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Development and optimisation of alginate-PMCG-alginate microcapsules for cell immobilisation by Orive, G, Hernández, R.M, Gascón, A.R, Igartua, M, Pedraz, J.L

“…Mechanical stability, uniformity of size, complete encapsulation of cells and optimal microenvironment are major challenges in the design and development of…”
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Cell microencapsulation technology for biomedical purposes: novel insights and challenges by Orive, Gorka, Gascón, Alicia R., Hernández, Rosa M., Igartua, Manuela, Luis Pedraz, José

“…The aim of cell microencapsulation technology is to treat multiple diseases in the absence of immunosuppression. Using this technique, cells are immobilized…”
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Comparative study of microcapsules elaborated with three polycations (PLL, PDL, PLO) for cell immobilization by De Castro, M., Orive, G., Hernández, R. M., Gascón, A. R., Pedraz, J. L.

“…Alginate-poly-L-lysine (PLL)-alginate microcapsules have been widely used in cell microencapsulation technology. However, the mechanical fragility and low…”
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