Search Results - "Gaschler, Gordon J"

Bacteria Challenge in Smoke-exposed Mice Exacerbates Inflammation and Skews the Inflammatory Profile by Gaschler, Gordon J, Skrtic, Marko, Zavitz, Caleb C. J, Lindahl, Maria, Onnervik, Per-Ola, Murphy, Timothy F, Sethi, Sanjay, Stampfli, Martin R

“…The pathogenesis of chronic obstructive pulmonary disease is associated with acute episodes of bacterial exacerbations. The most commonly isolated bacteria…”
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Innate immune processes are sufficient for driving cigarette smoke-induced inflammation in mice by Botelho, Fernando M, Gaschler, Gordon J, Kianpour, Sussan, Zavitz, Cale C J, Trimble, Nancy J, Nikota, Jake K, Bauer, Carla M T, Stämpfli, Martin R

“…The objective of this study was to characterize the impact of cigarette smoke exposure on lung immune and inflammatory processes. BALB/c and C57BL/6 mice were…”
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Cigarette Smoke Exposure Attenuates Cytokine Production by Mouse Alveolar Macrophages by Gaschler, Gordon J, Zavitz, Caleb C. J, Bauer, Carla M. T, Skrtic, Marko, Lindahl, Maria, Robbins, Clinton S, Chen, Biao, Stampfli, Martin R

“…Alveolar macrophages (aMs) play a central role in respiratory host defense by sensing microbial antigens and initiating immune-inflammatory responses early in…”
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Lung Epithelial CCAAT/Enhancer binding Protein-β Is Necessary for the Integrity of Inflammatory Responses to Cigarette Smoke by DIDON, Lukas, BARTON, Jenny L, ROOS, Abraham B, GASCHLER, Gordon J, BAUER, Carla M. T, BERG, Tove, STÄMPFLI, Martin R, NORD, Magnus

“…Cigarette smoke is the major cause of chronic obstructive pulmonary disease and lung cancer. The mechanisms by which smoking induces pulmonary dysfunction are…”
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Cigarette Smoke Impacts Immune Inflammatory Responses to Influenza in Mice by Robbins, Clinton S, Bauer, Carla M. T, Vujicic, Neda, Gaschler, Gordon J, Lichty, Brian D, Brown, Earl G, Stampfli, Martin R

“…Studies have shown that cigarette smoke impacts respiratory host defense mechanisms; however, it is poorly understood how these smoke-induced changes impact…”
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Animal models of chronic obstructive pulmonary disease exacerbations by Gaschler, Gordon J, Bauer, Carla M T, Zavitz, Caleb C J, Stämpfli, Martin R

“…Modeling acute exacerbations of chronic obstructive pulmonary disease (AECOPD) in animals has proven challenging due to the clinical and pathological…”
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Dysregulated Macrophage-Inflammatory Protein-2 Expression Drives Illness in Bacterial Superinfection of Influenza by Zavitz, Caleb C. J, Bauer, Carla M. T, Gaschler, Gordon J, Fraser, Katie M, Strieter, Robert M, Hogaboam, Cory M, Stampfli, Martin R

“…Influenza virus infection is a leading cause of death and disability throughout the world. Influenza-infected hosts are vulnerable to secondary bacterial…”
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Impact of cigarette smoke on T and B cell responsiveness by Zavitz, Caleb C.J., Gaschler, Gordon J., Robbins, Clinton S., Botelho, Fernando M., Cox, P. Gerard, Stampfli, Martin R.

“…Although its direct effects cannot be discounted, tobacco’s effects on the immune system have been proposed to play a key role in mediating its deleterious…”
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Lung Epithelial CCAAT/Enhancer-binding Protein-[Beta] Is Necessary for the Integrity of Inflammatory Responses to Cigarette Smoke by Didon, Lukas, Barton, Jenny L, Roos, Abraham B, Gaschler, Gordon J, Bauer, Carla M T, Berg, Tove, Stämpfli, Martin R, Nord, Magnus

“…Cigarette smoke is the major cause of chronic obstructive pulmonary disease and lung cancer. The mechanisms by which smoking induces pulmonary dysfunction are…”
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The impact of cigarette smoke-exposure on pathways of microbial-induced pulmonary inflammation by Gaschler, Gordon J

“…The cellular, molecular, and genetic mechanisms underlying the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD) are not well understood. The…”
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