Search Results - "Garzoni, Luciana"
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Osteoblasts and bone marrow mesenchymal stromal cells control hematopoietic stem cell migration and proliferation in 3D in vitro model
Published in PloS one (08-02-2010)“…Migration, proliferation, and differentiation of hematopoietic stem cells (HSCs) are dependent upon a complex three-dimensional (3D) bone marrow…”
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2
Experimental Social Stress: Dopaminergic Receptors, Oxidative Stress, and c-Fos Protein Are Involved in Highly Aggressive Behavior
Published in Frontiers in cellular neuroscience (17-08-2021)“…Aggression is defined as hostile behavior that results in psychological damage, injury and even death among individuals. When aggression presents itself in an…”
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3
Inhibition of TGF-β pathway reverts extracellular matrix remodeling in T. cruzi-infected cardiac spheroids
Published in Experimental cell research (15-01-2018)“…Chagasic cardiomyopathy (CC) is the main manifestation of Chagas Disease (CD). CC is a progressive dysfunctional illness, in which transforming growth factor…”
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“Chagas Express XXI”: A new ArtScience social technology for health and science education—A case study in Brazilian endemic areas of Chagas disease with an active search of chronic cases
Published in PLoS neglected tropical diseases (01-07-2021)“…Background Chagas Disease (CD) affects 6–7 million people worldwide and is related to poverty-promoting conditions. Chronic asymptomatic cases are mostly…”
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5
Biomarkers and Echocardiographic Predictors of Cardiovascular Outcome in Patients With Chronic Chagas Disease
Published in Journal of the American Heart Association (20-06-2023)“…Background Chagas disease (CD) presents an ominous prognosis. The predictive value of biomarkers and new echocardiogram parameters in adjusted models have not…”
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6
Selenium, TGF-Beta and Infectious Endemic Cardiopathy: Lessons from Benchwork to Clinical Application in Chagas Disease
Published in Biomolecules (Basel, Switzerland) (23-02-2022)“…For over 60 years, selenium (Se) has been known as an essential microelement to many biological functions, including cardiovascular homeostasis. This review…”
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Trypanosoma cruzi Promotes Transcriptomic Remodeling of the JAK/STAT Signaling and Cell Cycle Pathways in Myoblasts
Published in Frontiers in cellular and infection microbiology (17-06-2020)“…Chagas disease is responsible for more than 10,000 deaths per year and about 6 to 7 million infected people worldwide. In its chronic stage, patients can…”
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Amiodarone Inhibits Trypanosoma cruzi Infection and Promotes Cardiac Cell Recovery with Gap Junction and Cytoskeleton Reassembly In Vitro
Published in Antimicrobial Agents and Chemotherapy (01-01-2011)“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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9
Acute Chagas disease induces cerebral microvasculopathy in mice
Published in PLoS neglected tropical diseases (01-07-2014)“…Cardiomyopathy is the main clinical form of Chagas disease (CD); however, cerebral manifestations, such as meningoencephalitis, ischemic stroke and cognitive…”
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10
Transcriptomic Signatures of Alterations in a Myoblast Cell Line Infected with Four Distinct Strains of Trypanosoma cruzi
Published in The American journal of tropical medicine and hygiene (01-05-2010)“…We examined the extent to which different Trypanosoma cruzi strains induce transcriptomic changes in cultured L(6)E(9) myoblasts 72 hours after infection with…”
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11
Current Understanding of Human Polymorphism in Selenoprotein Genes: A Review of Its Significance as a Risk Biomarker
Published in International journal of molecular sciences (01-02-2024)“…Selenium has been proven to influence several biological functions, showing to be an essential micronutrient. The functional studies demonstrated the benefits…”
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12
Fibrosis and Hypertrophy Induced by Trypanosoma cruzi in a Three-Dimensional Cardiomyocyte-Culture System
Published in The Journal of infectious diseases (15-03-2008)“…Cardiac damages caused by in vivo infection with Trypanosoma cruzi are still not fully clarified. Here we describe for the first time an in vitro model of…”
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Effects of Selenium treatment on cardiac function in Chagas heart disease: Results from the STCC randomized Trial
Published in EClinicalMedicine (01-10-2021)“…Chagas disease (caused by Trypanosoma cruzi infection) evolves to chronic chagasic cardiomyopathy (CCC) affecting 1.8 million people worldwide. This is the…”
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14
Effect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice
Published in Scientific reports (06-12-2022)“…Central nervous system alterations was described in Chagas disease in both human and experimental models, leading to meningoencephalitis, stroke and cognitive…”
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Cerebral Microvascular Dysfunction and Inflammation Are Improved by Centrally Acting Antihypertensive Drugs in Metabolic Syndrome
Published in Metabolic syndrome and related disorders (01-02-2017)“…We aimed to investigate the effects of chronic oral treatment with centrally acting antihypertensive drugs, such as clonidine (CLO), an α -adrenoceptor…”
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Exploring the Dimensions of Pre-Clinical Research: 3D Cultures as an Investigative Model of Cardiac Fibrosis in Chagas Disease
Published in Biomedicines (25-06-2024)“…A three-dimensional (3D) cell culture can more precisely mimic tissues architecture and functionality, being a promising alternative model to study disease…”
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Dissecting coronary angiogenesis: 3D co-culture of cardiomyocytes with endothelial or mesenchymal cells
Published in Experimental cell research (15-11-2009)“…In embryogenesis, coronary blood vessels are formed by vasculogenesis from epicardium-derived progenitors. Subsequently, growing or regenerating myocardium…”
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18
Clinical trials for Chagas disease: etiological and pathophysiological treatment
Published in Frontiers in microbiology (2023)“…Chagas disease (CD) is caused by the flagellate protozoan . It is endemic in Latin America. Nowadays around 6 million people are affected worldwide, and 75…”
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Unraveling Chagas disease transmission through the oral route: Gateways to Trypanosoma cruzi infection and target tissues
Published in PLoS neglected tropical diseases (05-04-2017)“…Oral transmission of Trypanosoma cruzi, the causative agent of Chagas disease, is the most important route of infection in Brazilian Amazon and Venezuela…”
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Current understanding of the Trypanosoma cruzi-cardiomyocyte interaction
Published in Frontiers in immunology (2012)“…Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits multiple strategies to ensure its establishment and persistence in the host. Although this…”
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