Search Results - "Garzon, Ramiro"

Targeting microRNAs in cancer: rationale, strategies and challenges by Garzon, Ramiro, Croce, Carlo M, Marcucci, Guido

“…Key Points The rationale for using microRNAs (miRNAs) as anticancer drugs is based on two major findings: miRNA expression is deregulated in cancer compared…”
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Acute Myeloid Leukemia: A Concise Review by Saultz, Jennifer N, Garzon, Ramiro

“…Acute myeloid leukemia (AML) is a heterogeneous clonal disorder characterized by immature myeloid cell proliferation and bone marrow failure. Cytogenetics and…”
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MicroRNAs in Cancer by Garzon, Ramiro, Calin, George A, Croce, Carlo M

“…MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA…”
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Clinical Applications of MicroRNAs in Acute Myeloid Leukemia: A Mini-Review by Bhatnagar, Bhavana, Garzon, Ramiro

“…MicroRNAs (miRs) are short non-coding RNAs, typically 18-25 nucleotides in length, that are critically important, through their direct effects on target mRNAs,…”
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CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia by Chen, Ye, Jacamo, Rodrigo, Konopleva, Marina, Garzon, Ramiro, Croce, Carlo, Andreeff, Michael

“…We examined the role of microRNAs (miRNAs) in targeting the stromal-derived factor 1α/CXCR4 (SDF-1α/CXCR4) axis to overcome chemoresistance of AML cells…”
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Non-Coding RNAs Are Implicit in Chronic Myeloid Leukemia Therapy Resistance by Rudich, Alexander, Garzon, Ramiro, Dorrance, Adrienne

“…Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm initiated by the presence of the fusion gene BCR::ABL1. The development of tyrosine kinase…”
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Expression and functional relevance of long non-coding RNAs in acute myeloid leukemia stem cells by Bill, Marius, Papaioannou, Dimitrios, Karunasiri, Malith, Kohlschmidt, Jessica, Pepe, Felice, Walker, Christopher J., Walker, Allison E., Brannan, Zachary, Pathmanathan, Aparna, Zhang, Xiaoli, Mrózek, Krzysztof, LaRocco, Allison, Volinia, Stefano, Bloomfield, Clara D., Garzon, Ramiro, Dorrance, Adrienne M.

“…In acute myeloid leukemia (AML), novel therapies are needed to target not only the rapidly dividing AML blasts but also the distinct population of leukemia…”
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The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia by Papaioannou, Dimitrios, Petri, Andreas, Dovey, Oliver M., Terreri, Sara, Wang, Eric, Collins, Frances A., Woodward, Lauren A., Walker, Allison E., Nicolet, Deedra, Pepe, Felice, Kumchala, Prasanthi, Bill, Marius, Walker, Christopher J., Karunasiri, Malith, Mrózek, Krzysztof, Gardner, Miranda L., Camilotto, Virginia, Zitzer, Nina, Cooper, Jonathan L., Cai, Xiongwei, Rong-Mullins, Xiaoqing, Kohlschmidt, Jessica, Archer, Kellie J., Freitas, Michael A., Zheng, Yi, Lee, Robert J., Aifantis, Iannis, Vassiliou, George, Singh, Guramrit, Kauppinen, Sakari, Bloomfield, Clara D., Dorrance, Adrienne M., Garzon, Ramiro

“…Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the…”
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Expression and prognostic impact of lncRNAs in acute myeloid leukemia by Garzon, Ramiro, Volinia, Stefano, Papaioannou, Dimitrios, Nicolet, Deedra, Kohlschmidt, Jessica, Yan, Pearlly S, Mrózek, Krzysztof, Bucci, Donna, Carroll, Andrew J, Baer, Maria R, Wetzler, Meir, Carter, Thomas H, Powell, Bayard L, Kolitz, Jonathan E, Moore, Joseph O, Eisfeld, Ann-Kathrin, Blachly, James S, Blum, William, Caligiuri, Michael A, Stone, Richard M, Marcucci, Guido, Croce, Carlo M, Byrd, John C, Bloomfield, Clara D

“…Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, located within the intergenic stretches or overlapping antisense transcripts of…”
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Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia by Ranganathan, Parvathi, Yu, Xueyan, Na, Caroline, Santhanam, Ramasamy, Shacham, Sharon, Kauffman, Michael, Walker, Alison, Klisovic, Rebecca, Blum, William, Caligiuri, Michael, Croce, Carlo M., Marcucci, Guido, Garzon, Ramiro

“…Chromosome maintenance protein 1 (CRM1) is a nuclear export receptor involved in the active transport of tumor suppressors (eg, p53 and nucleophosmin) whose…”
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Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation by Li, Zhaoyong, Hassan, Mohammad Q., Jafferji, Mohammed, Aqeilan, Rami I., Garzon, Ramiro, Croce, Carlo M., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.

“…Bone tissue arises from mesenchymal cells induced into the osteoblast lineage by essential transcription factors and signaling cascades. MicroRNAs regulate…”
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MicroRNA 29b functions in acute myeloid leukemia by Garzon, Ramiro, Heaphy, Catherine E.A., Havelange, Violaine, Fabbri, Muller, Volinia, Stefano, Tsao, Twee, Zanesi, Nicola, Kornblau, Steven M., Marcucci, Guido, Calin, George A., Andreeff, Michael, Croce, Carlo M.

“…MicroRNAs (miRNAs) are associated with cytogenetics and molecular subtypes of acute myelogeneous leukemia (AML), but their impact on AML pathogenesis is poorly…”
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MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B by Fabbri, Muller, Garzon, Ramiro, Cimmino, Amelia, Liu, Zhongfa, Zanesi, Nicola, Callegari, Elisa, Liu, Shujun, Alder, Hansjuerg, Costinean, Stefan, Fernandez-Cymering, Cecilia, Volinia, Stefano, Guler, Gulnur, Morrison, Carl D, Chan, Kenneth K, Marcucci, Guido, Calin, George A, Huebner, Kay, Croce, Carlo M

“…MicroRNAs (miRNAs) are small, noncoding RNAs that regulate expression of many genes. Recent studies suggest roles of miRNAs in carcinogenesis. We and others…”
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A MicroRNA Signature of Hypoxia by Kulshreshtha, Ritu, Ferracin, Manuela, Wojcik, Sylwia E., Garzon, Ramiro, Alder, Hansjuerg, Agosto-Perez, Francisco J., Davuluri, Ramana, Liu, Chang-Gong, Croce, Carlo M., Negrini, Massimo, Calin, George A., Ivan, Mircea

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Knockout of both miR-15/16 loci induces acute myeloid leukemia by Lovat, Francesca, Fassan, Matteo, Sacchi, Diana, Ranganathan, Parvathi, Palamarchuk, Alexey, Bill, Marius, Karunasiri, Malith, Gasparini, Pierluigi, Nigita, Giovanni, Distefano, Rosario, Veneziano, Dario, Dorrance, Adrienne M., Garzon, Ramiro, Croce, Carlo M.

“…MicroRNAs (miRNAs) have been extensively reported to be associated with hematological malignancies. The loss of miR-15a/16–1 at chromosome 13q14 is a hallmark…”
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MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1 by Garzon, Ramiro, Liu, Shujun, Fabbri, Muller, Liu, Zhongfa, Heaphy, Catherine E.A., Callegari, Elisa, Schwind, Sebastian, Pang, Jiuxia, Yu, Jianhua, Muthusamy, Natarajan, Havelange, Violaine, Volinia, Stefano, Blum, William, Rush, Laura J., Perrotti, Danilo, Andreeff, Michael, Bloomfield, Clara D., Byrd, John C., Chan, Kenneth, Wu, Lai-Chu, Croce, Carlo M., Marcucci, Guido

“…Aberrant DNA hypermethylation contributes to myeloid leukemogenesis by silencing structurally normal genes involved in hematopoiesis. MicroRNAs (miRNAs) are…”
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Targeted Delivery of microRNA-29b by Transferrin-Conjugated Anionic Lipopolyplex Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia by XIAOMENG HUANG, SCHWIND, Sebastian, BLUM, William, PERROTTI, Danilo, BYRD, John C, BLOOMFIELD, Clara D, CALIGIURI, Michael A, LEE, Robert J, GARZON, Ramiro, MUTHUSAMY, Natarajan, LEE, Ly James, MARCUCCI, Guido, BO YU, SANTHANAM, Ramasamy, HONGYAN WANG, HOELLERBAUER, Pia, MIMS, Alice, KLISOVIC, Rebecca, WALKER, Alison R, CHAN, Kenneth K

“…miR-29b directly or indirectly targets genes involved in acute myeloid leukemia (AML), namely, DNMTs, CDK6, SP1, KIT, and FLT3. Higher miR-29b pretreatment…”
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MiR-15a and miR-16-1 cluster functions in human leukemia by Calin, George A, Cimmino, Amelia, Fabbri, Muller, Ferracin, Manuela, Wojcik, Sylwia E, Shimizu, Masayoshi, Taccioli, Cristian, Zanesi, Nicola, Garzon, Ramiro, Aqeilan, Rami I, Alder, Hansjuerg, Volinia, Stefano, Rassenti, Laura, Liu, Xiuping, Liu, Chang-gong, Kipps, Thomas J, Negrini, Massimo, Croce, Carlo M

“…MicroRNAs (miRNAs) are short noncoding RNAs regulating gene expression that play roles in human diseases, including cancer. Each miRNA is predicted to regulate…”
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miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts by Eiring, Anna M., Harb, Jason G., Neviani, Paolo, Garton, Christopher, Oaks, Joshua J., Spizzo, Riccardo, Liu, Shujun, Schwind, Sebastian, Santhanam, Ramasamy, Hickey, Christopher J., Becker, Heiko, Chandler, Jason C., Andino, Raul, Cortes, Jorge, Hokland, Peter, Huettner, Claudia S., Bhatia, Ravi, Roy, Denis C., Liebhaber, Stephen A., Caligiuri, Michael A., Marcucci, Guido, Garzon, Ramiro, Croce, Carlo M., Calin, George A., Perrotti, Danilo

“…MicroRNAs and heterogeneous ribonucleoproteins (hnRNPs) are posttranscriptional gene regulators that bind mRNA in a sequence-specific manner. Here, we report…”
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MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis by Pichiorri, Flavia, Suh, Sung-Suk, Ladetto, Marco, Kuehl, Michael, Palumbo, Tiziana, Drandi, Daniela, Taccioli, Cristian, Zanesi, Nicola, Alder, Hansjuerg, Hagan, John P, Munker, Reinhold, Volinia, Stefano, Boccadoro, Mario, Garzon, Ramiro, Palumbo, Antonio, Aqeilan, Rami I, Croce, Carlo M

“…Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery of microRNAs (miRNAs), a class of small…”
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