Search Results - "Gary W. Lawrence"

Ca2+ Signalling Induced by NGF Identifies a Subset of Capsaicin-Excitable Neurons Displaying Enhanced Chemo-Nociception in Dorsal Root Ganglion Explants from Adult pirt-GCaMP3 Mouse by Lawrence, Gary W., Zurawski, Tomas H., Dolly, J. Oliver

“…Nociceptors sense hazards via plasmalemmal cation channels, including transient receptor potential vanilloid 1 (TRPV1). Nerve growth factor (NGF) sensitises…”
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Safety of Onabotulinumtoxin A in Chronic Migraine: A Systematic Review and Meta-Analysis of Randomized Clinical Trials by Corasaniti, Maria Tiziana, Bagetta, Giacinto, Nicotera, Pierluigi, Tarsitano, Assunta, Tonin, Paolo, Sandrini, Giorgio, Lawrence, Gary W, Scuteri, Damiana

“…Some 14% of global prevalence, based on high-income country populations, suffers from migraine. Chronic migraine is very disabling, being characterized by at…”
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Population Coding of Capsaicin Concentration by Sensory Neurons Revealed Using Ca2+ Imaging of Dorsal Root Ganglia Explants from Adult pirt-GCaMP3 Mouse by Lawrence, Gary W, Zurawski, Tomas H, Dong, Xinzhong, Dolly, J Oliver

“…Background/Aims: Nociceptors detect noxious capsaicin (CAPS) via the transient receptor potential vanilloid 1 (TRPV1) ion channel, but coding mechanisms for…”
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NGF Enhances CGRP Release Evoked by Capsaicin from Rat Trigeminal Neurons: Differential Inhibition by SNAP-25-Cleaving Proteases by Belinskaia, Mariia, Zurawski, Tomas, Kaza, Seshu Kumar, Antoniazzi, Caren, Dolly, J Oliver, Lawrence, Gary W

“…Nerve growth factor (NGF) is known to intensify pain in various ways, so perturbing pertinent effects without negating its essential influences on neuronal…”
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Bipartite Activation of Sensory Neurons by a TRPA1 Agonist Allyl Isothiocyanate Is Reflected by Complex Ca2+ Influx and CGRP Release Patterns: Enhancement by NGF and Inhibition with VAMP and SNAP-25 Cleaving Botulinum Neurotoxins by Belinskaia, Mariia, Wang, Jiafu, Kaza, Seshu Kumar, Antoniazzi, Caren, Zurawski, Tomas, Dolly, J. Oliver, Lawrence, Gary W.

“…The trafficking of transient receptor potential (TRP) channels to the plasma membrane and the release of calcitonin gene-related peptide (CGRP) from trigeminal…”
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Botulinum Neurotoxin Chimeras Suppress Stimulation by Capsaicin of Rat Trigeminal Sensory Neurons In Vivo and In Vitro by Antoniazzi, Caren, Belinskaia, Mariia, Zurawski, Tomas, Kaza, Seshu Kumar, Dolly, J Oliver, Lawrence, Gary W

“…Chimeras of botulinum neurotoxin (BoNT) serotype A (/A) combined with /E protease might possess improved analgesic properties relative to either parent, due to…”
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The Glycine max Conserved Oligomeric Golgi (COG) Complex Functions During a Defense Response to Heterodera glycines by Lawaju, Bisho Ram, Niraula, Prakash, Lawrence, Gary W., Lawrence, Kathy S., Klink, Vincent P.

“…The conserved oligomeric Golgi (COG) complex, functioning in retrograde trafficking, is a universal structure present among eukaryotes that maintains the…”
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Extravesicular intraneuronal migration of internalized botulinum neurotoxins without detectable inhibition of distal neurotransmission by Lawrence, Gary W, Ovsepian, Saak V, Wang, Jiafu, Aoki, K Roger, Dolly, J Oliver

“…Intracellular protein transport routes can be studied using toxins that exploit these to enter cells. BoNTA (botulinum neurotoxin type A) is a protease that…”
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Quantitative field testing Heterodera glycines from metagenomic DNA samples isolated directly from soil under agronomic production by Li, Yan, Lawrence, Gary W, Lu, Shien, Balbalian, Clarissa, Klink, Vincent P

“…A quantitative PCR procedure targeting the Heterodera glycines ortholog of the Caenorhabditis elegans uncoordinated-78 gene was developed. The procedure…”
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Novel Chimeras of Botulinum Neurotoxins A and E Unveil Contributions from the Binding, Translocation, and Protease Domains to Their Functional Characteristics by Wang, Jiafu, Meng, Jianghui, Lawrence, Gary W., Zurawski, Tomas H., Sasse, Astrid, Bodeker, MacDara O., Gilmore, Marcella A., Fernández-Salas, Ester, Francis, Joseph, Steward, Lance E., Aoki, K. Roger, Dolly, J. Oliver

“…Hyperexcitability disorders of cholinergically innervated muscles are treatable with botulinum neurotoxin (BoNT) A. The seven serotypes (A–G) potently block…”
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Quantitative field testing Rotylenchulus reniformis DNA from metagenomic samples isolated directly from soil by Showmaker, Kurt, Lawrence, Gary W, Lu, Shien, Balbalian, Clarissa, Klink, Vincent P

“…A quantitative PCR procedure targeting the β-tubulin gene determined the number of Rotylenchulus reniformis Linford & Oliveira 1940 in metagenomic DNA samples…”
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The mitogen activated protein kinase (MAPK) gene family functions as a cohort during the Glycine max defense response to Heterodera glycines by McNeece, Brant T., Sharma, Keshav, Lawrence, Gary W., Lawrence, Kathy S., Klink, Vincent P.

“…Mitogen activated protein kinases (MAPKs) play important signal transduction roles. However, little is known regarding how they influence the gene expression…”
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Activation of TRPV1 Mediates Calcitonin Gene-Related Peptide Release, Which Excites Trigeminal Sensory Neurons and Is Attenuated by a Retargeted Botulinum Toxin with Anti-Nociceptive Potential by Meng, Jianghui, Ovsepian, Saak V, Wang, Jiafu, Pickering, Mark, Sasse, Astrid, Aoki, K. Roger, Lawrence, Gary W, Dolly, J. Oliver

“…Excessive release of inflammatory/pain mediators from peripheral sensory afferents renders nerve endings hyper-responsive, causing central sensitization and…”
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A Glycine max homolog of NON-RACE SPECIFIC DISEASE RESISTANCE 1 (NDR1) alters defense gene expression while functioning during a resistance response to different root pathogens in different genetic backgrounds by McNeece, Brant T., Pant, Shankar R., Sharma, Keshav, Niruala, Prakash, Lawrence, Gary W., Klink, Vincent P.

“…A Glycine max homolog of the Arabidopsis thaliana NON-RACE SPECIFIC DISEASE RESISTANCE 1 (NDR1) coiled-coil nucleotide binding leucine rich repeat (CC-NB-LRR)…”
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Harpin-inducible defense signaling components impair infection by the ascomycete Macrophomina phaseolina by Lawaju, Bisho R., Lawrence, Kathy S., Lawrence, Gary W., Klink, Vincent P.

“…Soybean (Glycine max) infection by the charcoal rot (CR) ascomycete Macrophomina phaseolina is enhanced by the soybean cyst nematode (SCN) Heterodera glycines…”
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Chapter 3: Molecular basis for the therapeutic effectiveness of botulinum neurotoxin type A by Dolly, J. Oliver, Lawrence, Gary W.

“…The utility of botulinum neurotoxin type A (BoNT/A) for treating overactive muscles and endocrine glands is attributable to a unique conflation of properties…”
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Syntaxin 31 functions in Glycine max resistance to the plant parasitic nematode Heterodera glycines by Pant, Shankar R, Matsye, Prachi D, McNeece, Brant T, Sharma, Keshav, Krishnavajhala, Aparna, Lawrence, Gary W, Klink, Vincent P

“…A Glycine max syntaxin 31 homolog (Gm-SYP38) was identified as being expressed in nematode-induced feeding structures known as syncytia undergoing an…”
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Botulinum Toxin A Detrusor Injections Reduce Postsynaptic Muscular M2, M3, P2X2, and P2X3 Receptors in Children and Adolescents Who Have Neurogenic Detrusor Overactivity: A Single-blind Study by Schulte-Baukloh, Heinrich, Priefert, Judith, Knispel, Helmut H, Lawrence, Gary W, Miller, Kurt, Neuhaus, Jochen

“…Objective To analyze the effect of OnabotulinumtoxinA detrusor injections on postsynaptic muscular receptors in children and adolescents with neurogenic…”
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Excitatory cholinergic and purinergic signaling in bladder are equally susceptible to botulinum neurotoxin a consistent with co-release of transmitters from efferent fibers by Lawrence, Gary W, Aoki, K Roger, Dolly, J Oliver

“…Mediators of neuromuscular transmission in rat bladder strips were dissected pharmacologically to examine their susceptibilities to inhibition by botulinum…”
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The expression of a naturally occurring, truncated allele of an α-SNAP gene suppresses plant parasitic nematode infection by Matsye, Prachi D., Lawrence, Gary W., Youssef, Reham M., Kim, Kyung-Hwan, Lawrence, Katheryn S., Matthews, Benjamin F., Klink, Vincent P.

“…Transcriptional mapping experiments of the major soybean cyst nematode resistance locus, rhg1 , identified expression of the vesicular transport machinery…”
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