Search Results - "Gary M Brittenham"

Iron-Chelating Therapy for Transfusional Iron Overload by Brittenham, Gary M

“…A 16-year-old boy with sickle cell anemia requires long-term red-cell transfusion. Prophylactic iron-chelating therapy is recommended. Iron chelators bind to…”
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Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women by Stoffel, Nicole U, Zeder, Christophe, Brittenham, Gary M, Moretti, Diego, Zimmermann, Michael B

“…In iron-depleted women without anemia, oral iron supplements induce an increase in serum hepcidin (SHep) that persists for 24 hours, decreasing iron absorption…”
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Validation of a batch cultivation protocol for fecal microbiota of Kenyan infants by Rachmühl, Carole, Lacroix, Christophe, Giorgetti, Ambra, Stoffel, Nicole U, Zimmermann, Michael B, Brittenham, Gary M, Geirnaert, Annelies

“…The combination of cultivation studies with molecular analysis approaches allows characterization of the complex human gut microbiota in depth. In vitro…”
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Physiologically based serum ferritin thresholds for iron deficiency in children and non-pregnant women: a US National Health and Nutrition Examination Surveys (NHANES) serial cross-sectional study by Mei, Zuguo, Addo, O Yaw, Jefferds, Maria Elena, Sharma, Andrea J, Flores-Ayala, Rafael C, Brittenham, Gary M

“…Serum ferritin concentrations are the most widely used indicator for iron deficiency. WHO determined that insufficient data are available to revise the serum…”
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Quantitative susceptibility mapping (QSM) minimizes interference from cellular pathology in R2 estimation of liver iron concentration by Li, Jianqi, Lin, Huimin, Liu, Tian, Zhang, Zhuwei, Prince, Martin R., Gillen, Kelly, Yan, Xu, Song, Qi, Hua, Ting, Zhao, Xiance, Zhang, Miao, Zhao, Yu, Li, Gaiying, Tang, Guangyu, Yang, Guang, Brittenham, Gary M., Wang, Yi

“…Background A challenge for R2 and R2* methods in measuring liver iron concentration (LIC) is that fibrosis, fat, and other hepatic cellular pathology…”
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Acute chest syndrome, airway inflammation and lung function in sickle cell disease by De, Aliva, Williams, Sanford, Yao, Yujing, Jin, Zhezhen, Brittenham, Gary M, Kattan, Meyer, Lovinsky-Desir, Stephanie, Lee, Margaret T

“…Acute chest syndrome (ACS) is an acute complication in SCD but its effects on lung function are not well understood. Inflammation is a key component of SCD…”
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Non-invasive detection of iron deficiency by fluorescence measurement of erythrocyte zinc protoporphyrin in the lip by Hennig, Georg, Homann, Christian, Teksan, Ilknur, Hasbargen, Uwe, Hasmüller, Stephan, Holdt, Lesca M., Khaled, Nadia, Sroka, Ronald, Stauch, Thomas, Stepp, Herbert, Vogeser, Michael, Brittenham, Gary M.

“…Worldwide, more individuals have iron deficiency than any other health problem. Most of those affected are unaware of their lack of iron, in part because…”
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Integrated quantitative susceptibility and R2 mapping for evaluation of liver fibrosis: An ex vivo feasibility study by Jafari, Ramin, Hectors, Stefanie J., Koehne de González, Anne K., Spincemaille, Pascal, Prince, Martin R., Brittenham, Gary M., Wang, Yi

“…To develop a method for noninvasive evaluation of liver fibrosis, we investigated the differential sensitivities of quantitative susceptibility mapping (QSM)…”
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Noninvasive measurement of iron: report of an NIDDK workshop by Brittenham, Gary M., Badman, David G.

“…An international workshop on the noninvasive measurement of iron was conducted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)…”
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Accuracy of Capillary Hemoglobin Measurements for the Detection of Anemia among U.S. Low-Income Toddlers and Pregnant Women by Boghani, Safia, Mei, Zuguo, Perry, Geraldine S, Brittenham, Gary M, Cogswell, Mary E

“…The aim of this study is to evaluate the accuracy of capillary hemoglobin (Hb) measurements in detecting anemia among low-income toddlers (aged 12-35 months)…”
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Short-term periods of strenuous physical activity lower iron absorption by Brittenham, Gary M

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Hepatic Iron Concentration and Total Body Iron Stores in Thalassemia Major by Angelucci, Emanuele, Brittenham, Gary M, McLaren, Christine E, Ripalti, Marta, Baronciani, Donatella, Giardini, Claudio, Galimberti, Maria, Polchi, Paola, Lucarelli, Guido

“…Quantitative studies of iron balance in patients with thalassemia major have been limited by the lack of a method for determining the total amount of stored…”
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An Ethiopian Pattern of Human Adaptation to High-Altitude Hypoxia by Beall, Cynthia M., Decker, Michael J., Brittenham, Gary M., Kushner, Irving, Gebremedhin, Amha, Strohl, Kingman P.

“…We describe, in Ethiopia, a third successful pattern of human adaptation to high-altitude hypoxia that contrasts with both the Andean "classic" (erythrocytosis…”
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Is Erythrocyte Protoporphyrin a Better Single Screening Test for Iron Deficiency Compared to Hemoglobin or Mean Cell Volume in Children and Women? by Mei, Zuguo, Flores-Ayala, Rafael C, Grummer-Strawn, Laurence M, Brittenham, Gary M

“…Hemoglobin (Hb), mean cell volume (MCV), and erythrocyte protoporphyrin (EP) are commonly used to screen for iron deficiency (ID), but systematic evaluation of…”
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Breathhold multiecho fast spin-echo pulse sequence for accurate R2 measurement in the heart and liver by Kim, Daniel, Jensen, Jens H., Wu, Ed X., Sheth, Sujit S., Brittenham, Gary M.

“…Measurement of proton transverse relaxation rates (R2) is a generally useful means for quantitative characterization of pathological changes in tissue with a…”
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MR characterization of hepatic storage iron in transfusional iron overload by Tang, Haiying, Jensen, Jens H., Sammet, Christina L., Sheth, Sujit, Swaminathan, Srirama V., Hultman, Kristi, Kim, Daniel, Wu, Ed X., Brown, Truman R., Brittenham, Gary M.

“…Purpose To quantify the two principal forms of hepatic storage iron, diffuse, soluble iron (primarily ferritin), and aggregated, insoluble iron (primarily…”
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Separate MRI quantification of dispersed (ferritin-like) and aggregated (hemosiderin-like) storage iron by Jensen, Jens H., Tang, Haiying, Tosti, Christina L., Swaminathan, Srirama V., Nunez, Alvaro, Hultman, Kristi, Szulc, Kamila U., Wu, Ed X., Kim, Daniel, Sheth, Sujit, Brown, Truman R., Brittenham, Gary M.

“…A new MRI method is proposed for separately quantifying the two principal forms of tissue storage (nonheme) iron: ferritin iron, a dispersed, soluble fraction…”
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Randomized phase 2 trial of monthly vitamin D to prevent respiratory complications in children with sickle cell disease by Lee, Margaret T., Kattan, Meyer, Fennoy, Ilene, Arpadi, Stephen M., Miller, Rachel L., Cremers, Serge, McMahon, Donald J., Nieves, Jeri W., Brittenham, Gary M.

“…In sickle cell disease, respiratory infection and asthma may lead to respiratory complications that are a leading cause of morbidity and mortality. Vitamin D…”
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How I treat anemia with red blood cell transfusion and iron by Carson, Jeffrey L, Brittenham, Gary M

“…Severe anemia is commonly treated with red blood cell transfusion. Clinical trials have demonstrated that a restrictive transfusion strategy of 7 to 8 g/dL is…”
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Iron Deficiency in Chronic Pediatric Heart Failure: Overall Assessment and Outcomes in Dilated Cardiomyopathy by Phillips, Lia, Richmond, Marc, Neunert, Cindy, Jin, Zhezhen, Brittenham, Gary M.

“…To evaluate the frequency of iron status assessment in pediatric heart failure and the prevalence and adverse effects of absolute iron deficiency in dilated…”
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