Search Results - "Gary D. Lopaschuk"

Cardiac Energy Metabolism in Heart Failure by Lopaschuk, Gary D., Karwi, Qutuba G., Tian, Rong, Wende, Adam R., Abel, E. Dale

“…Alterations in cardiac energy metabolism contribute to the severity of heart failure. However, the energy metabolic changes that occur in heart failure are…”
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Metabolic Modulators in Heart Disease: Past, Present, and Future by Lopaschuk, Gary D., PhD

“…Abstract Ischemic heart disease and heart failure are leading causes of mortality and morbidity worldwide. They continue to be major burden on health care…”
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Empagliflozin’s Fuel Hypothesis: Not so Soon by Lopaschuk, Gary D., Verma, Subodh

“…The EMPA-REG OUTCOME trial (Zinman et al., 2015) established cardioprotective effects of empagliflozin in high-risk diabetic patients, but the underlying…”
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Energy Metabolic Phenotype of the Cardiomyocyte During Development, Differentiation, and Postnatal Maturation by Lopaschuk, Gary D, Jaswal, Jagdip S

“…Dramatic maturational changes occur in cardiac energy metabolism during cardiac development, differentiation, and postnatal growth. These changes in energy…”
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Targeting mitochondrial oxidative metabolism as an approach to treat heart failure by Fillmore, Natasha, Lopaschuk, Gary D.

“…Heart failure is a major cause of morbidity and mortality in the world. Cardiac energy metabolism, specifically fatty acid and glucose metabolism, is altered…”
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Myocardial Energy Substrate Metabolism in Heart Failure : from Pathways to Therapeutic Targets by Fukushima, Arata, Milner, Kenneth, Gupta, Abhishek, Lopaschuk, Gary D

“…Despite recent advances in therapy, heart failure remains a major cause of mortality and morbidity and is a growing healthcare burden worldwide. Alterations in…”
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Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease by Cherian, Sam, Lopaschuk, Gary D, Carvalho, Eugenia

“…Epicardial and perivascular fat depot size is considered an index of cardiac and visceral obesity. The functional and anatomic proximity of epicardial adipose…”
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Complex Energy Metabolic Changes in Heart Failure with Preserved Ejection Fraction and Heart Failure with Reduced Ejection Fraction by De Jong, Kirstie A., BMedSci (hons), Lopaschuk, Gary D., PhD

“…Abstract Alterations in cardiac energy metabolism contribute to the severity of heart failure. However, the energy metabolic changes that occur in heart…”
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Loss of Metabolic Flexibility in the Failing Heart by Karwi, Qutuba G, Uddin, Golam M, Ho, Kim L, Lopaschuk, Gary D

“…To maintain its high energy demand the heart is equipped with a highly complex and efficient enzymatic machinery that orchestrates ATP production using…”
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Myocardial Fatty Acid Metabolism in Health and Disease by Lopaschuk, Gary D, Ussher, John R, Folmes, Clifford D. L, Jaswal, Jagdip S, Stanley, William C

“…Cardiovascular Research Group, Mazankowski Alberta Heart Institute, University of Alberta, Alberta, Canada; and Division of Cardiology, Department of Medicine,…”
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Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation by Abo Alrob, Osama, Lopaschuk, Gary D

“…CoA (coenzyme A) and its derivatives have a critical role in regulating cardiac energy metabolism. This includes a key role as a substrate and product in the…”
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Targeting fatty acid and carbohydrate oxidation — A novel therapeutic intervention in the ischemic and failing heart by Jaswal, Jagdip S., Keung, Wendy, Wang, Wei, Ussher, John R., Lopaschuk, Gary D.

“…Cardiac ischemia and its consequences including heart failure, which itself has emerged as the leading cause of morbidity and mortality in developed countries…”
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ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity by Patel, Vaibhav B, Mori, Jun, McLean, Brent A, Basu, Ratnadeep, Das, Subhash K, Ramprasath, Tharmarajan, Parajuli, Nirmal, Penninger, Josef M, Grant, Maria B, Lopaschuk, Gary D, Oudit, Gavin Y

“…Obesity is increasing in prevalence and is strongly associated with metabolic and cardiovascular disorders. The renin-angiotensin system (RAS) has emerged as a…”
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Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency by Ho, Kim L, Zhang, Liyan, Wagg, Cory, Al Batran, Rami, Gopal, Keshav, Levasseur, Jody, Leone, Teresa, Dyck, Jason R B, Ussher, John R, Muoio, Deborah M, Kelly, Daniel P, Lopaschuk, Gary D

“…The failing heart is energy-starved and inefficient due to perturbations in energy metabolism. Although ketone oxidation has been shown recently to increase in…”
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Concurrent diabetes and heart failure: interplay and novel therapeutic approaches by Karwi, Qutuba G, Ho, Kim L, Pherwani, Simran, Ketema, Ezra B, Sun, Qiuyu, Lopaschuk, Gary D

“…Abstract Diabetes mellitus increases the risk of developing heart failure, and the co-existence of both diseases worsens cardiovascular outcomes,…”
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The role of acetylation in obesity-induced cardiac metabolic alterations by Ketema, Ezra B, Lopaschuk, Gary D

“…Obesity is a growing public health problem, with its prevalence rate having tripled in the last five decades. It has been shown that obesity is associated with…”
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The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity by Gao, Su, Ghoshal, Sarbani, Zhang, Liyan, Stevens, Joseph R., McCommis, Kyle S., Finck, Brian N., Lopaschuk, Gary D., Butler, Andrew A.

“…The peptide hormone adropin regulates energy metabolism in skeletal muscle and plays important roles in the regulation of metabolic homeostasis. Besides…”
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Optimization of cardiac metabolism in heart failure by Nagoshi, Tomohisa, Yoshimura, Michihiro, Rosano, Giuseppe M C, Lopaschuk, Gary D, Mochizuki, Seibu

“…The derangement of the cardiac energy substrate metabolism plays a key role in the pathogenesis of heart failure. The utilization of non-carbohydrate…”
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Cardiac branched-chain amino acid oxidation is reduced during insulin resistance in the heart by Fillmore, Natasha, Wagg, Cory S, Zhang, Liyan, Fukushima, Arata, Lopaschuk, Gary D

“…Recent studies have proposed that elevated branched-chain amino acids (BCAAs) may induce insulin resistance (IR) in muscle secondary to increased BCAA…”
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Myocardial Substrate Metabolism in the Normal and Failing Heart by Stanley, William C, Recchia, Fabio A, Lopaschuk, Gary D

“…Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, Ohio; Scuola Superiore Sant'Anna, Pisa, Italy;…”
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