Search Results - "Garvie, Colin W."

Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase by Garvie, Colin W., Wu, Xiaoyun, Papanastasiou, Malvina, Lee, Sooncheol, Fuller, James, Schnitzler, Gavin R., Horner, Steven W., Baker, Andrew, Zhang, Terry, Mullahoo, James P., Westlake, Lindsay, Hoyt, Stephanie H., Toetzl, Marcus, Ranaghan, Matthew J., de Waal, Luc, McGaunn, Joseph, Kaplan, Bethany, Piccioni, Federica, Yang, Xiaoping, Lange, Martin, Tersteegen, Adrian, Raymond, Donald, Lewis, Timothy A., Carr, Steven A., Cherniack, Andrew D., Lemke, Christopher T., Meyerson, Matthew, Greulich, Heidi

“…DNMDP and related compounds, or velcrins, induce complex formation between the phosphodiesterase PDE3A and the SLFN12 protein, leading to a cytotoxic response…”
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Assessing optimal: inequalities in codon optimization algorithms by Ranaghan, Matthew J, Li, Jeffrey J, Laprise, Dylan M, Garvie, Colin W

“…Custom genes have become a common resource in recombinant biology over the last 20 years due to the plummeting cost of DNA synthesis. These genes are often…”
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Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state by Miller, Peter G., Sathappa, Murugappan, Moroco, Jamie A., Jiang, Wei, Qian, Yue, Iqbal, Sumaiya, Guo, Qi, Giacomelli, Andrew O., Shaw, Subrata, Vernier, Camille, Bajrami, Besnik, Yang, Xiaoping, Raffier, Cerise, Sperling, Adam S., Gibson, Christopher J., Kahn, Josephine, Jin, Cyrus, Ranaghan, Matthew, Caliman, Alisha, Brousseau, Merissa, Fischer, Eric S., Lintner, Robert, Piccioni, Federica, Campbell, Arthur J., Root, David E., Garvie, Colin W., Ebert, Benjamin L.

“…PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification…”
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Structural Studies of Ets-1/Pax5 Complex Formation on DNA by Garvie, Colin W, Hagman, James, Wolberger, Cynthia

“…Pax5 regulates the B cell-specific expression of the mb-1 gene together with members of the Ets family of transcriptional activators. The Ets proteins on their…”
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Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling by Corsello, Steven M, Nagari, Rohith T, Spangler, Ryan D, Rossen, Jordan, Kocak, Mustafa, Bryan, Jordan G, Humeidi, Ranad, Peck, David, Wu, Xiaoyun, Tang, Andrew A, Wang, Vickie M, Bender, Samantha A, Lemire, Evan, Narayan, Rajiv, Montgomery, Philip, Ben-David, Uri, Garvie, Colin W, Chen, Yejia, Rees, Matthew G, Lyons, Nicholas J, McFarland, James M, Wong, Bang T, Wang, Li, Dumont, Nancy, O'Hearn, Patrick J, Stefan, Eric, Doench, John G, Harrington, Caitlin N, Greulich, Heidi, Meyerson, Matthew, Vazquez, Francisca, Subramanian, Aravind, Roth, Jennifer A, Bittker, Joshua A, Boehm, Jesse S, Mader, Christopher C, Tsherniak, Aviad, Golub, Todd R

“…Anti-cancer uses of non-oncology drugs have occasionally been found, but such discoveries have been serendipitous. We sought to create a public resource…”
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Structural Analysis of the Autoinhibition of Ets-1 and Its Role in Protein Partnerships by Garvie, Colin W, Pufall, Miles A, Graves, Barbara J, Wolberger, Cynthia

“…The DNA-binding activity of the eukaryotic transcription factor Ets-1 (E26 avian erythroblastosis virus oncogene- E t wenty- s ix) is negatively regulated by…”
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Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12 by Wu, Xiaoyun, Schnitzler, Gavin R., Gao, Galen F., Diamond, Brett, Baker, Andrew R., Kaplan, Bethany, Williamson, Kaylyn, Westlake, Lindsay, Lorrey, Selena, Lewis, Timothy A., Garvie, Colin W., Lange, Martin, Hayat, Sikander, Seidel, Henrik, Doench, John, Cherniack, Andrew D., Kopitz, Charlotte, Meyerson, Matthew, Greulich, Heidi

“…Cytotoxic molecules can kill cancer cells by disrupting critical cellular processes or by inducing novel activities…”
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Solution-based approach to study binding to the eIF4E cap-binding site using CD spectroscopy by Garvie, Colin W.

“…The eukaryotic initiation factor 4E (eIF4E) is the key component of the translational initiation complex that recruits mRNA by binding to a unique “cap”…”
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The Autophagy-Related Beclin‑1 Protein Requires the Coiled-Coil and BARA Domains To Form a Homodimer with Submicromolar Affinity by Ranaghan, Matthew J, Durney, Michael A, Mesleh, Michael F, McCarren, Patrick R, Garvie, Colin W, Daniels, Douglas S, Carey, Kimberly L, Skepner, Adam P, Levine, Beth, Perez, Jose R

“…Beclin-1 (BECN1) is an essential component of macroautophagy. This process is a highly conserved survival mechanism that recycles damaged cellular components…”
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Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12 by Wu, Xiaoyun, Schnitzler, Gavin R., Gao, Galen F., Diamond, Brett, Baker, Andrew R., Kaplan, Bethany, Williamson, Kaylyn, Westlake, Lindsay, Lorrey, Selena, Lewis, Timothy A., Garvie, Colin W., Lange, Martin, Hayat, Sikander, Seidel, Henrik, Doench, John, Cherniack, Andrew D., Kopitz, Charlotte, Meyerson, Matthew, Greulich, Heidi

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A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein by Pop, Marius S, Stransky, Nicolas, Garvie, Colin W, Theurillat, Jean-Philippe, Hartman, Emily C, Lewis, Timothy A, Zhong, Cheng, Culyba, Elizabeth K, Lin, Fallon, Daniels, Douglas S, Pagliarini, Raymond, Ronco, Lucienne, Koehler, Angela N, Garraway, Levi A

“…Members of the ETS transcription factor family have been implicated in several cancers, where they are often dysregulated by genomic derangement. ETS variant 1…”
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Development of a novel, sensitive cell-based corin assay by Lambertz, Pascal, Theisen, Laura, Längst, Natalie, Garvie, Colin W., MacDonald, Bryan T., Yu, John, Elowe, Nadine H., Zubov, Dmitry, Kaushik, Virendar K., Wunder, Frank

“…[Display omitted] Corin (atrial natriuretic peptide-converting enzyme, EC 3.4.21) is a transmembrane serine protease expressed in cardiomyocytes. Corin exerts…”
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Point mutations at the catalytic site of PCSK9 inhibit folding, autoprocessing, and interaction with the LDL receptor by Garvie, Colin W., Fraley, Cara V., Elowe, Nadine H., Culyba, Elizabeth K., Lemke, Christopher T., Hubbard, Brian K., Kaushik, Virendar K., Daniels, Douglas S.

“…Circulating low‐density lipoprotein cholesterol (LDLc) is regulated by membrane‐bound LDL receptor (LDLr). Upon LDLc and LDLr interaction the complex is…”
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Mechanistic insights into RNase L through use of an MDMX-derived multi-functional protein domain by Garvie, Colin W., Vasanthavada, Keshav, Xiang, Qing

“…RNase L is part of the innate immune response to viral infection. It is activated by a small oligonucleotide (2–5A) whose synthesis is initiated as part of the…”
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Highly Cooperative Recruitment of Ets-1 and Release of Autoinhibition by Pax5 by Fitzsimmons, Daniel, Lukin, Kara, Lutz, Ryan, Garvie, Colin W., Wolberger, Cynthia, Hagman, James

“…Pax5 (paired box binding factor 5) is a critical regulator of transcription and lineage commitment in B lymphocytes. In B cells, mb-1…”
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Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses by Wang, Minxian, Lee-Kim, Vivian S., Atri, Deepak S., Elowe, Nadine H., Yu, John, Garvie, Colin W., Won, Hong-Hee, Hadaya, Joseph E., MacDonald, Bryan T., Trindade, Kevin, Melander, Olle, Rader, Daniel J., Natarajan, Pradeep, Kathiresan, Sekar, Kaushik, Virendar K., Khera, Amit V., Gupta, Rajat M.

“…Corin is a protease expressed in cardiomyocytes that plays a key role in salt handling and intravascular volume homeostasis via activation of natriuretic…”
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Assembly of the RFX complex on the MHCII promoter: Role of RFXAP and RFXB in relieving autoinhibition of RFX5 by Garvie, Colin W., Boss, Jeremy M.

“…The RFX complex is key component of a multi-protein complex that regulates the expression of the Major Histocompatibility Class II (MHCII) genes, whose…”
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Structural and Functional Studies of an Intermediate on the Pathway to Operator Binding by Escherichia coli MetJ by He, Yi-Yuan, Garvie, Colin W., Elworthy, Stone, Manfield, Iain W., McNally, Teresa, Lawrenson, Isobel D., Phillips, Simon E.V., Stockley, Peter G.

“…We present the results of in vitro DNA-binding assays for a mutant protein (Q44K) of the E. coli methionine repressor, MetJ, as well as the crystal structure…”
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Formation of the RFX gene regulatory complex induces folding of the interaction domain of RFXAP by Briggs, LaTese, Laird, Kholiswa, Boss, Jeremy M., Garvie, Colin W.

“…Major histocompatibility complex class II (MHCII) molecules have a central role in the mammalian adaptive immune response against infection. The level of the…”
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Solution Structure of the Heterotrimeric Complex between the Interaction Domains of RFX5 and RFXAP from the RFX Gene Regulatory Complex by Laird, Kholiswa M., Briggs, LaTese L., Boss, Jeremy M., Summers, Michael F., Garvie, Colin W.

“…The mammalian immune response is mediated by a heterotetrameric transcriptional control complex, called regulatory factor X (RFX), that regulates the…”
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