Colorectal Cancer Imaging with Iodine-123-Labeled CEA Monoclonal Antibody Fragments

This prospective, randomized multicenter study in 62 patients was designed to evaluate the efficacy and safety of radioimmunodetection (RAID) with 123I-labeled fragments, F(ab')2 and Fab', of IMMU-4, an anti-CEA monoclonal antibody (Immu-RAID-CEA). It was found that ImmuRAID-CEA was safe a...

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Bibliographic Details
Published in:	The Journal of nuclear medicine (1978) Vol. 34; no. 1; pp. 61 - 70
Main Authors:	Goldenberg, David M, Wlodkowski, Theodore J, Sharkey, Robert M, Silberstein, Edward B, Serafini, Aldo N, Garty, Izak I, Van Heertum, Ronald L, Higginbotham-Ford, Edith A, Kotler, Jon A, Balasubramanian, N, Swayne, Lawrence C, Hansen, Hans J, Pinsky, Carl M
Format:	Journal Article
Language:	English
Published:	United States Soc Nuclear Med 01-01-1993
Subjects:	Adult Aged Aged, 80 and over Carcinoembryonic Antigen - immunology Colorectal Neoplasms - diagnostic imaging Double-Blind Method Female Humans Immunoglobulin Fragments Iodine Radioisotopes Male Middle Aged Prospective Studies Radioimmunodetection Sensitivity and Specificity
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Summary:	This prospective, randomized multicenter study in 62 patients was designed to evaluate the efficacy and safety of radioimmunodetection (RAID) with 123I-labeled fragments, F(ab')2 and Fab', of IMMU-4, an anti-CEA monoclonal antibody (Immu-RAID-CEA). It was found that ImmuRAID-CEA was safe and disclosed colorectal cancer sites at least 1 cm in size. The positive predictive value by lesions was 77% initially, and increased to 91% after 7 mo of follow-up. Only one patient developed a low level of HAMA. In 17 patients with 32 surgically confirmed lesions, there were 9% true-positive lesions for CT when RAID was false-negative, and 22% for RAID when CT was false-negative. Either CT or RAID detected all 32 lesions. In this small series, therefore, RAID was shown to complement CT findings by confirming suspected tumors and disclosing new lesions which had previously been occult.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23
ISSN:	0161-5505 1535-5667