Search Results - "Gartlon, J."

Further neurochemical and behavioural investigation of Brattleboro rats as a putative model of schizophrenia by Cilia, J., Gartlon, JE, Shilliam, C., Dawson, LA, Moore, SH, Jones, DNC

“…Brattleboro (BRAT) rats are a mutant variant of the Long-Evans (LE) strain deficient in the neurohormone vasopressin. BRAT rats show behavioural alterations…”
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Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat by Woolley, M. L., Waters, K. A., Gartlon, J. E., Lacroix, L. P., Jennings, C., Shaughnessy, F., Ong, A., Pemberton, D. J., Harries, M. H., Southam, E., Jones, D. N. C., Dawson, L. A.

“…Rationale Positive allosteric modulators of the glutamatergic α-amino-3-hydroxy-5-methyl-4-isoazolepropionic acid (AMPA) receptor do not stimulate AMPA…”
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Evaluation of a proposed in vitro test strategy using neuronal and non-neuronal cell systems for detecting neurotoxicity by Gartlon, J., Kinsner, A., Bal-Price, A., Coecke, S., Clothier, R.H.

“…The European Commission White Paper, “Strategy for a future chemicals policy” (EC, 2001) is estimated to require the testing of approximately 30,000 ‘existing’…”
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Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity by JONES, Declan N. C, GARTLON, Jane, PORTER, Rod A, HAGAN, Jim J, HUNTER, A. Jackie, UPTON, Neil, PARKER, Frederick, TAYLOR, Stephen G, ROUTLEDGE, Carol, HEMMATI, Panida, MUNTON, Richard P, ASHMEADE, Tracey E, HATCHER, Jonathan P, JOHNS, Amanda

“…Orexin-A and orexin-B are hypothalamic neuropeptides derived from a 130-amino acid precursor, prepro-orexin, and are potent agonists at both the orexin-1 (OX1)…”
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The effects of ziprasidone on regional c-Fos expression in the rat forebrain by JENNINGS, C. A, CLUDERAY, J. E, GARTLON, J, CILIA, J, LLOYD, A, JONES, D. N. C, SOUTHAM, E

“…Typical and atypical antipsychotic drugs produce characteristic patterns of immediate early gene expression in rat forebrain that are considered to reflect…”
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Central effects of urotensin-II following ICV administration in rats by GARTLON, Jane, PARKER, Frederick, HUNTER, Jackie A, JONES, Declan N. C, HARRISON, David C, DOUGLAS, Stephen A, ASHMEADE, Tracey E, RILEY, Graham J, HUGHES, Zoe A, TAYLOR, Stephen G, MUNTON, Richard P, HAGAN, Jim J

“…Urotensin-II (U-II) has recently been identified as an agonist for the G-protein-coupled receptor, GPR14. Detection of both U-II and GPR14 mRNA in the brain…”
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The European Food Safety Authority (EFSA) re-evaluation of EU approved food additives by Lodi, F., Gartlon, J., Kenigswald, H., Kass, G.

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Long-term behavioural, molecular and morphological effects of neonatal NMDA receptor antagonism by Wiseman Harris, Laura, Sharp, Trevor, Gartlon, Jane, Jones, Declan N. C., Harrison, Paul J.

“…Brief N‐methyl‐d‐aspartate (NMDA) receptor blockade in neonatal rats has been reported to increase neuronal apoptosis. We replicated this finding using MK‐801…”
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The European Food Safety Authority's (EFSAs) Risk Assessment Process for EU Authorised Food Additives and Nutrient Sources by Gartlon, Joanne, Lodi, Federica, Lahaniatis, Majlinda, Kenigswald, Hugues

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Guidance documents on submissions for the technical and toxicological evaluation of substances proposed for use as food additives or nutrient sources in the EU by Lodi, Federica, Gartlon, Joanne, Lahaniatis, Majlinda, Kenigswald, Hugues

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Nitric oxide stimulates PC12 cell proliferation via cGMP and inhibits at higher concentrations mainly via energy depletion by Bal-Price, Anna, Gartlon, Joanne, Brown, Guy C.

“…We investigated the mechanisms by which nitric oxide (NO) from an NO donor (DETA/NO) regulates proliferation of pheochromocytoma PC12 cells. The NO donor…”
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The value of alternative testing for neurotoxicity in the context of regulatory needs by Coecke, Sandra, Eskes, Chantra, Gartlon, Joanne, Kinsner, Agnieszka, Price, Anna, van Vliet, Erwin, Prieto, Pilar, Boveri, Monica, Bremer, Susanne, Adler, Sarah, Pellizzer, Cristian, Wendel, Albrecht, Hartung, Thomas

“…Detection and characterisation of chemical-induced toxic effects in the central and peripheral nervous system represent a major challenge for employing newly…”
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Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats by GARTLON, Jane, SZEKERES, Philip, DUXON, Mark, ASHMEADE, Tracey E, HARRISON, David C, MURDOCK, Paul, WILSON, Shelagh, ENNACEUR, Abdel, ATKINS, Alan, HEIDBREDER, Christian, HAGAN, Jim J, HUNTER, A. Jackie, PULLEN, Mark, JONES, Declan N. C, SARAU, Henry M, AIYAR, Nambi, SHABON, Usman, MICHALOVICH, David, STEPLEWSKI, Klaudia, ELLIS, Cathy, ELSHOURBAGY, Nabil

“…Neuromedin-U (NmU) is an agonist at NMU1R and NMU2R. The brain distribution of NmU and its receptors, in particular NMU2R, suggests widespread central roles…”
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Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat: Special Issue on Cognitive Enhancers by WOOLLEY, M. L, WATERS, K. A, JONES, D. N. C, DAWSON, L. A, GARTLON, J. E, LACROIX, L. P, JENNINGS, C, SHAUGHNESSY, F, ONG, A, PEMBERTON, D. J, HARRIES, M. H, SOUTHAM, E

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Development of a mechanistically-based genetically engineered PC12 cell system to detect p53-mediated cytotoxicity by van Vliet, Erwin, Eskes, Chantra, Stingele, Silvia, Gartlon, Joanne, Price, Anna, Farina, Massimo, Ponti, Jessica, Hartung, Thomas, Sabbioni, Enrico, Coecke, Sandra

“…The human wild type p53 gene, key for apoptosis, was introduced into the pheochromocytoma (PC12) cell line, to create a mechanistically-based in vitro test…”
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Comparison of the effects of ziprasidone and haloperidol on regional fos expression in rat forebrain by Jennings, C.A., Southam, E., Cluderay, J.E., Gartlon, J., Cilia, J., Jones, D.N.

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Effect of the selective dopamine D3 receptor antagonist SB-277011 on regional fos expression in the rat forebrain by Southam, E., Jennings, C.A., Cluderay, J.E., Gartlon, J., Cilia, J., Jones, D.N.

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Effect of the selective dopamine D sub(3) receptor antagonist SB-277011-A on regional c-Fos-like expression in rat forebrain by Southam, E, Lloyd, A, Jennings, CA, Cluderay, JE, Cilia, J, Gartlon, JE, Jones, DNC

“…SB-277011-A is a dopamine D sub(3) receptor antagonist that exhibits over 100-fold selectivity over dopamine D sub(2) receptors and a broad spectrum of other…”
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Urotensin-II, a neuropeptide ligand for GPR14, induces c- fos in the rat brain by Gartlon, Jane E., Ashmeade, Tracey, Duxon, Mark, Hagan, Jim J., Jones, Declan N.C.

“…The vasoactive peptide urotensin-II and its receptor, GPR14 (now known as UT receptor), are localised in the mammalian central nervous system. Accordingly,…”
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