Search Results - "Gartenhaus, Ronald B."

Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL by Kapadia, Bandish, Nanaji, Nahid M., Bhalla, Kavita, Bhandary, Binny, Lapidus, Rena, Beheshti, Afshin, Evens, Andrew M., Gartenhaus, Ronald B.

“…Altered lipid metabolism and aberrant protein translation are strongly associated with cancerous outgrowth; however, the inter-regulation of these key…”
Get full text

Targeting of mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice by Heredia, Alonso, Nhut Le, Ronald B. Gartenhaus, Edward Sausville, Sandra Medina-Moreno, Juan C. Zapata, Charles Davis, Robert C. Gallo, Robert R. Redfield

“…Most HIV antiretrovirals target viral proteins. Unfortunately, HIV mutates under drug pressure, which can lead to drug resistance. Targeting cellular proteins…”
Get full text

Novel eIF4A1 inhibitors with anti-tumor activity in lymphoma by Kayastha, Forum, Herrington, Noah B, Kapadia, Bandish, Roychowdhury, Anirban, Nanaji, Nahid, Kellogg, Glen E, Gartenhaus, Ronald B

“…Deregulated translation initiation is implicated extensively in cancer initiation and progression. It is actively pursued as a viable target that circumvents…”
Get full text

Targeting the translational machinery as a novel treatment strategy for hematologic malignancies by Hagner, Patrick R., Schneider, Abraham, Gartenhaus, Ronald B.

“…The dysregulation of protein synthesis evident in the transformed phenotype has opened up a burgeoning field of research in cancer biology. Translation…”
Get full text

MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL by Landon, Ari L., Muniandy, Parameswary A., Shetty, Amol C., Lehrmann, Elin, Volpon, Laurent, Houng, Simone, Zhang, Yongqing, Dai, Bojie, Peroutka, Raymond, Mazan-Mamczarz, Krystyna, Steinhardt, James, Mahurkar, Anup, Becker, Kevin G., Borden, Katherine L., Gartenhaus, Ronald B.

“…The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development…”
Get full text

Role of microRNA deregulation in the pathogenesis of diffuse large B-cell lymphoma (DLBCL) by Mazan-Mamczarz, Krystyna, Gartenhaus, Ronald B

“…Abstract MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression at the post-transcriptional level through its sequence…”
Get full text

SIRT3, a metabolic target linked to ataxia-telangiectasia mutated (ATM) gene deficiency in diffuse large B-cell lymphoma by Bhalla, Kavita, Jaber, Sausan, Reagan, Kayla, Hamburg, Arielle, Underwood, Karen F., Jhajharia, Aditya, Singh, Maninder, Bhandary, Binny, Bhat, Shambhu, Nanaji, Nahid M., Hisa, Ruching, McCracken, Carrie, Creasy, Heather Huot, Lapidus, Rena G., Kingsbury, Tami, Mayer, Dirk, Polster, Brian, Gartenhaus, Ronald B.

“…Inactivation of Ataxia-telangiectasia mutated (ATM) gene results in an increased risk to develop cancer. We show that ATM deficiency in diffuse large B-cell…”
Get full text

A Circulating microRNA Signature Predicts Age-Based Development of Lymphoma by Beheshti, Afshin, Vanderburg, Charles, McDonald, J Tyson, Ramkumar, Charusheila, Kadungure, Tatenda, Zhang, Hong, Gartenhaus, Ronald B, Evens, Andrew M

“…Extensive epidemiological data have demonstrated an exponential rise in the incidence of non-Hodgkin lymphoma (NHL) that is associated with increasing age. The…”
Get full text

Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development by Mazan-Mamczarz, Krystyna, Zhao, X Frank, Dai, Bojie, Steinhardt, James J, Peroutka, Raymond J, Berk, Kimberly L, Landon, Ari L, Sadowska, Mariola, Zhang, Yongqing, Lehrmann, Elin, Becker, Kevin G, Shaknovich, Rita, Liu, Zhenqiu, Gartenhaus, Ronald B

“…Deregulation of the translational machinery is emerging as a critical contributor to cancer development. The contribution of microRNAs in translational gene…”
Get full text

The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma by Bhalla, Savita, Evens, Andrew M., Dai, Bojie, Prachand, Sheila, Gordon, Leo I., Gartenhaus, Ronald B.

“…The RAS/RAF/MEK/ERK signaling pathway has been largely unexplored as a potential therapeutic target in lymphoma. The novel 2nd generation anti-MEK small…”
Get full text

Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma by Dai, Bojie, Zhao, X. Frank, Mazan-Mamczarz, Krystyna, Hagner, Patrick, Corl, Sharon, Bahassi, El Mustapha, Lu, Song, Stambrook, Peter J., Shapiro, Paul, Gartenhaus, Ronald B.

“…Distinct oncogenic signalling cascades have been associated with non-Hodgkin lymphoma. ERK1/2 signalling elicits both transcriptional and post-transcriptional…”
Get full text

Author Correction: Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL by Bhalla, Kavita, Jaber, Sausan, Nahid M., Nanaji, Underwood, Karen, Beheshti, Afshin, Landon, Ari, Bhandary, Binny, Bastian, Paul, Evens, Andrew M., Haley, John, Polster, Brian, Gartenhaus, Ronald B.

“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper…”
Get full text

Imbalanced Matriptase Pericellular Proteolysis Contributes to the Pathogenesis of Malignant B-Cell Lymphomas by Chou, Feng-Pai, Chen, Ya-Wen, Zhao, Xianfeng F, Xu-Monette, Zijun Y, Young, Ken H, Gartenhaus, Ronald B, Wang, Jehng-Kang, Kataoka, Hiroaki, Zuo, Annie H, Barndt, Robert J, Johnson, Michael, Lin, Chen-Yong

“…Membrane-associated serine protease matriptase is widely expressed by epithelial/carcinoma cells in which its proteolytic activity is tightly controlled by the…”
Get full text

c-Myc and E2F1 drive PBK/TOPK expression in high-grade malignant lymphomas by Hu, Fang, Gartenhaus, Ronald B, Zhao, Xianfeng F, Fang, Hong-Bin, Minkove, Samuel, Poss, Daniella E, Rapoport, Aaron P

“…Abstract c-Myc has been implicated in a variety of hematologic malignancies including Burkitt's lymphoma. Targeting c-Myc driven growth pathways could be…”
Get full text

ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes by Mazan-Mamczarz, Krystyna, Hagner, Patrick R., Zhang, Yongqing, Dai, Bojie, Lehrmann, Elin, Becker, Kevin G., Keene, Jack D., Gorospe, Myriam, Liu, Zhenqui, Gartenhaus, Ronald B.

“…Maintenance of genomic stability depends on the DNA damage response, a biologic barrier in early stages of cancer development. Failure of this response results…”
Get full text

AMPK signaling: A targetable tumor suppressor pathway? by Schneider, Abraham, Gartenhaus, Ronald B.

“…Commentary to: AMPK as a therapeutic target in renal cell carcinoma Jennifer Woodard, Sonali Joshi, Benoit Viollet, Nissim Hay and Leonidas C. Platanias…”
Get full text

Kernel based methods for accelerated failure time model with ultra-high dimensional data by Liu, Zhenqiu, Chen, Dechang, Tan, Ming, Jiang, Feng, Gartenhaus, Ronald B

“…Most genomic data have ultra-high dimensions with more than 10,000 genes (probes). Regularization methods with L₁ and L(p) penalty have been extensively…”
Get full text

The RUNX2 transcription factor cooperates with the YES-associated protein, YAP65, to promote cell transformation by Vitolo, Michele I., Anglin, Ian E., Mahoney, William M., Renoud, Keli J., Gartenhaus, Ronald B., Bachman, Kurtis E., Passaniti, Antonino

“…The Runt box domain DNA-binding transcription factors (RUNX) play key roles in hematopoietic, bone, and gastric development. These factors regulate…”
Get full text

Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells by Evens, Andrew M., Lecane, Philip, Magda, Darren, Prachand, Sheila, Singhal, Seema, Nelson, Jeff, Miller, Richard A., Gartenhaus, Ronald B., Gordon, Leo I.

“…Motexafin gadolinium (MGd), an expanded porphyrin, is a tumor-selective redox-mediator that reacts with many intracellular reducing metabolites. Because redox…”
Get full text

Gene and pathway identification with Lp penalized Bayesian logistic regression by Liu, Zhenqiu, Gartenhaus, Ronald B, Tan, Ming, Jiang, Feng, Jiao, Xiaoli

“…Identifying genes and pathways associated with diseases such as cancer has been a subject of considerable research in recent years in the area of…”
Get full text