Search Results - "Garten, Antje"

Physiological and pathophysiological roles of NAMPT and NAD metabolism by Garten, Antje, Schuster, Susanne, Penke, Melanie, Gorski, Theresa, de Giorgis, Tommaso, Kiess, Wieland

“…Key Points Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the intracellular nicotinamide adenine dinucleotide (NAD) pool and, thus, regulates…”
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Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures by Elhassan, Yasir S., Kluckova, Katarina, Fletcher, Rachel S., Schmidt, Mark S., Garten, Antje, Doig, Craig L., Cartwright, David M., Oakey, Lucy, Burley, Claire V., Jenkinson, Ned, Wilson, Martin, Lucas, Samuel J.E., Akerman, Ildem, Seabright, Alex, Lai, Yu-Chiang, Tennant, Daniel A., Nightingale, Peter, Wallis, Gareth A., Manolopoulos, Konstantinos N., Brenner, Charles, Philp, Andrew, Lavery, Gareth G.

“…Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress and has been reported to decline with aging in preclinical models, but…”
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Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1 by Garten, Antje, Grohmann, Theresa, Kluckova, Katarina, Lavery, Gareth G, Kiess, Wieland, Penke, Melanie

“…Sorafenib is a multi-kinase inhibitor and one of the few systemic treatment options for patients with advanced hepatocellular carcinomas (HCCs). Resistance to…”
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Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity by Le Duc, Diana, Lin, Chen-Ching, Popkova, Yulia, Yang, Zuqin, Akhil, Velluva, Çakir, M. Volkan, Grunewald, Sonja, Simon, Jan-Christoph, Dietz, Andreas, Dannenberger, Dirk, Garten, Antje, Lemke, Johannes R., Schiller, Jürgen, Blüher, Matthias, Nono Nankam, Pamela Arielle, Rolle-Kampczyk, Ulrike, von Bergen, Martin, Kelso, Janet, Schöneberg, Torsten

“…Background Elucidation of lipid metabolism and accumulation mechanisms is of paramount importance to understanding obesity and unveiling therapeutic targets…”
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FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells by Schuster, Susanne, Penke, Melanie, Gorski, Theresa, Gebhardt, Rolf, Weiss, Thomas S., Kiess, Wieland, Garten, Antje

“…Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme of the NAD salvage pathway starting from nicotinamide. Cancer cells have an increased demand…”
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NAD metabolites interfere with proliferation and functional properties of THP-1 cells by Petin, Katharina, Weiss, Ronald, Müller, Gerd, Garten, Antje, Grahnert, Anja, Sack, Ulrich, Hauschildt, Sunna

“…Over the past few years the NAD-related compounds nicotinamide (NAM), nicotinamide riboside (NR) and 1-methylnicotinamide (MNA) have been established as…”
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Obesity-An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances by Gjermeni, Erind, Kirstein, Anna S, Kolbig, Florentien, Kirchhof, Michael, Bundalian, Linnaeus, Katzmann, Julius L, Laufs, Ulrich, Blüher, Matthias, Garten, Antje, Le Duc, Diana

“…Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the…”
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Phospholipid Scramblase 4 (PLSCR4) Regulates Adipocyte Differentiation via PIP3-Mediated AKT Activation by Barth, Lisa A. G., Nebe, Michèle, Kalwa, Hermann, Velluva, Akhil, Kehr, Stephanie, Kolbig, Florentien, Prabutzki, Patricia, Kiess, Wieland, Le Duc, Diana, Garten, Antje, Kirstein, Anna S.

“…Phospholipid scramblase 4 (PLSCR4) is a member of a conserved enzyme family with high relevance for the remodeling of phospholipid distribution in the plasma…”
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Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells by Fletcher, Rachel S, Ratajczak, Joanna, Doig, Craig L, Oakey, Lucy A, Callingham, Rebecca, da Silva Xavier, Gabriella, Garten, Antje, Elhassan, Yasir S, Redpath, Philip, Migaud, Marie E, Philp, Andrew, Brenner, Charles, Canto, Carles, Lavery, Gareth G

“…Abstract Objective Augmenting nicotinamide adenine dinucleotide (NAD+ ) availability may protect skeletal muscle from age-related metabolic decline. Dietary…”
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Phenotype-tissue expression and exploration (PTEE) resource facilitates the choice of tissue for RNA-seq-based clinical genetics studies by Velluva, Akhil, Radtke, Maximillian, Horn, Susanne, Popp, Bernt, Platzer, Konrad, Gjermeni, Erind, Lin, Chen-Ching, Lemke, Johannes R, Garten, Antje, Schöneberg, Torsten, Blüher, Matthias, Abou Jamra, Rami, Le Duc, Diana

“…RNA-seq emerges as a valuable method for clinical genetics. The transcriptome is "dynamic" and tissue-specific, but typically the probed tissues to analyze…”
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Molecular Characteristics of Serum Visfatin and Differential Detection by Immunoassays by Körner, Antje, Garten, Antje, Blüher, Matthias, Tauscher, Roy, Kratzsch, Jürgen, Kiess, Wieland

“…Context: There are controversial results concerning the association of visfatin with obesity and diabetes. We aimed to characterize molecular features of…”
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Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes by Schuster, Susanne, Penke, Melanie, Gorski, Theresa, Petzold-Quinque, Stefanie, Damm, Georg, Gebhardt, Rolf, Kiess, Wieland, Garten, Antje

“…Resveratrol is reported to possess chemotherapeutic properties in several cancers. In this study, we wanted to investigate the molecular mechanisms of…”
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Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling by Lone, Mehraj-U-Din, Miyan, Javed, Asif, Mohammad, Malik, Showkat A, Dubey, Parul, Singh, Varsha, Singh, Kavita, Mitra, Kalyan, Pandey, Deepali, Haq, Wahajul, Amita, Himanshi, Singh, Prince Kumar, Kiess, Wieland, Kaessner, Franziska, Garten, Antje, Bhadauria, Smrati

“…The mechanistic (or mammalian) target of rapamycin (mTOR), a Ser/Thr kinase, associates with different subunits forming two functionally distinct complexes,…”
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Altered gene expression profiles impair the nervous system development in individuals with 15q13.3 microdeletion by Körner, Marek B., Velluva, Akhil, Bundalian, Linnaeus, Radtke, Maximilian, Lin, Chen-Ching, Zacher, Pia, Bartolomaeus, Tobias, Kirstein, Anna S., Mrestani, Achmed, Scholz, Nicole, Platzer, Konrad, Teichmann, Anne-Christin, Hentschel, Julia, Langenhan, Tobias, Lemke, Johannes R., Garten, Antje, Abou Jamra, Rami, Le Duc, Diana

“…The 15q13.3 microdeletion has pleiotropic effects ranging from apparently healthy to severely affected individuals. The underlying basis of the variable…”
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Association of Whole Blood Amino Acid and Acylcarnitine Metabolome with Anthropometry and IGF-I Serum Levels in Healthy Children and Adolescents in Germany by Jensch, Ricky, Baber, Ronny, Körner, Antje, Kiess, Wieland, Ceglarek, Uta, Garten, Antje, Vogel, Mandy

“…Physiological changes of blood amino acids and acylcarnitines during healthy child development are poorly studied. The LIFE (Leipziger Forschungszentrum für…”
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Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells by Penke, Melanie, Schuster, Susanne, Gorski, Theresa, Gebhardt, Rolf, Kiess, Wieland, Garten, Antje

“…Nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide adenine dinucleotide (NAD) levels are crucial for liver function. The saturated fatty acid…”
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Altered hepatic lipid metabolism in mice lacking both the melanocortin type 4 receptor and low density lipoprotein receptor by Lede, Vera, Meusel, Andrej, Garten, Antje, Popkova, Yulia, Penke, Melanie, Franke, Christin, Ricken, Albert, Schulz, Angela, Kiess, Wieland, Huster, Daniel, Schöneberg, Torsten, Schiller, Jürgen

“…Obesity is often associated with dyslipidemia and hepatosteatosis. A number of animal models of non-alcoholic fatty liver disease (NAFLD) are established but…”
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Pediatric percentiles for transient elastography measurements - effects of age, sex, weight status and pubertal stage by Brunnert, Lina, Puasa, Ika Damayanti, Garten, Antje, Penke, Melanie, Gaul, Susanne, Grafe, Nico, Karlas, Thomas, Kiess, Wieland, Flemming, Gunter, Vogel, Mandy

“…Background and aims Transient Elastography is a non-invasive, cost-efficient, non-ionizing, observer-independent and reliable method to detect liver fibrosis…”
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Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine by Sommer, Grit, Garten, Antje, Petzold, Stefanie, Beck-Sickinger, Annette G, Blüher, Matthias, Stumvoll, Michael, Fasshauer, Mathias

“…Over the last few years, it has become obvious that obesity and insulin resistance are linked by a variety of proteins secreted by adipocytes. Visfatin/PBEF…”
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Relation of Whole Blood Amino Acid and Acylcarnitine Metabolome to Age, Sex, BMI, Puberty, and Metabolic Markers in Children and Adolescents by Hirschel, Josephin, Vogel, Mandy, Baber, Ronny, Garten, Antje, Beuchel, Carl, Dietz, Yvonne, Dittrich, Julia, Körner, Antje, Kiess, Wieland, Ceglarek, Uta

“…Changes in the metabolic fingerprint of blood during child growth and development are a largely under-investigated area of research. The examination of such…”
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